Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014536060> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2014536060 abstract "Through the monitoring of the auto-fluorescent mitochondrial metabolic coenzymes, NADH (Nicotinamide AdenineDinucleotide) and FAD (Flavoprotein Adenine Dinucleotide), the redox state of metabolism can be probed in real time inmany intact organs, but its use has not been fully developed in lungs. The ratio of these fluorophores, (NADH/FAD),referred to as the mitochondrial redox ratio (RR), can be used as a quantitative metabolic marker of tissue. We havedesigned a fluorometer that can be used to monitor lung surface NADH and FAD fluorescence in isolated perfusedlungs. Surface fluorescence NADH and FAD signals were acquired in the absence (control) and presence ofpentachlorophenol (PCP), rotenone, and potassium cyanide (KCN). Rotenone, an inhibitor of complex I, increased RRby 18%, predominantly due to an increase in NADH signal. KCN, an inhibitor of complex IV reduced the chain andresulted in an increase of 33% in RR, as a result of 23% increase in NADH and 8% in FAD . PCP, an uncoupler whichoxidizes the respiratory chain, decreased RR by 18% as a result of 14% decrease in NADH signal and 4% increase inFAD signal. These results demonstrate the ability of surface fluorometry to detect changes in lung tissue mitochondrialredox state in isolated perfused lungs." @default.
- W2014536060 created "2016-06-24" @default.
- W2014536060 creator A5001255219 @default.
- W2014536060 creator A5012411069 @default.
- W2014536060 creator A5040579783 @default.
- W2014536060 creator A5040619480 @default.
- W2014536060 creator A5073960891 @default.
- W2014536060 date "2012-02-03" @default.
- W2014536060 modified "2023-09-23" @default.
- W2014536060 title "Optical studies of tissue mitochondrial redox in isolated perfused rat lungs" @default.
- W2014536060 cites W1211960147 @default.
- W2014536060 cites W1497174676 @default.
- W2014536060 cites W171940975 @default.
- W2014536060 cites W1971547812 @default.
- W2014536060 cites W2053175640 @default.
- W2014536060 cites W2056880228 @default.
- W2014536060 cites W2060201843 @default.
- W2014536060 cites W2075226542 @default.
- W2014536060 cites W2095225601 @default.
- W2014536060 cites W2096369405 @default.
- W2014536060 cites W2103947312 @default.
- W2014536060 cites W2128192158 @default.
- W2014536060 cites W2156312824 @default.
- W2014536060 cites W2397994762 @default.
- W2014536060 doi "https://doi.org/10.1117/12.909474" @default.
- W2014536060 hasPublicationYear "2012" @default.
- W2014536060 type Work @default.
- W2014536060 sameAs 2014536060 @default.
- W2014536060 citedByCount "2" @default.
- W2014536060 countsByYear W20145360602014 @default.
- W2014536060 countsByYear W20145360602016 @default.
- W2014536060 crossrefType "proceedings-article" @default.
- W2014536060 hasAuthorship W2014536060A5001255219 @default.
- W2014536060 hasAuthorship W2014536060A5012411069 @default.
- W2014536060 hasAuthorship W2014536060A5040579783 @default.
- W2014536060 hasAuthorship W2014536060A5040619480 @default.
- W2014536060 hasAuthorship W2014536060A5073960891 @default.
- W2014536060 hasConcept C107872376 @default.
- W2014536060 hasConcept C178790620 @default.
- W2014536060 hasConcept C181199279 @default.
- W2014536060 hasConcept C185592680 @default.
- W2014536060 hasConcept C197957613 @default.
- W2014536060 hasConcept C24840226 @default.
- W2014536060 hasConcept C2775859393 @default.
- W2014536060 hasConcept C2776901170 @default.
- W2014536060 hasConcept C2778389096 @default.
- W2014536060 hasConcept C2779912340 @default.
- W2014536060 hasConcept C2779965811 @default.
- W2014536060 hasConcept C28859421 @default.
- W2014536060 hasConcept C3020377403 @default.
- W2014536060 hasConcept C55493867 @default.
- W2014536060 hasConcept C55904794 @default.
- W2014536060 hasConcept C71995715 @default.
- W2014536060 hasConcept C75520062 @default.
- W2014536060 hasConcept C86803240 @default.
- W2014536060 hasConceptScore W2014536060C107872376 @default.
- W2014536060 hasConceptScore W2014536060C178790620 @default.
- W2014536060 hasConceptScore W2014536060C181199279 @default.
- W2014536060 hasConceptScore W2014536060C185592680 @default.
- W2014536060 hasConceptScore W2014536060C197957613 @default.
- W2014536060 hasConceptScore W2014536060C24840226 @default.
- W2014536060 hasConceptScore W2014536060C2775859393 @default.
- W2014536060 hasConceptScore W2014536060C2776901170 @default.
- W2014536060 hasConceptScore W2014536060C2778389096 @default.
- W2014536060 hasConceptScore W2014536060C2779912340 @default.
- W2014536060 hasConceptScore W2014536060C2779965811 @default.
- W2014536060 hasConceptScore W2014536060C28859421 @default.
- W2014536060 hasConceptScore W2014536060C3020377403 @default.
- W2014536060 hasConceptScore W2014536060C55493867 @default.
- W2014536060 hasConceptScore W2014536060C55904794 @default.
- W2014536060 hasConceptScore W2014536060C71995715 @default.
- W2014536060 hasConceptScore W2014536060C75520062 @default.
- W2014536060 hasConceptScore W2014536060C86803240 @default.
- W2014536060 hasLocation W20145360601 @default.
- W2014536060 hasOpenAccess W2014536060 @default.
- W2014536060 hasPrimaryLocation W20145360601 @default.
- W2014536060 hasRelatedWork W1588010863 @default.
- W2014536060 hasRelatedWork W1969160142 @default.
- W2014536060 hasRelatedWork W1980966649 @default.
- W2014536060 hasRelatedWork W1981321560 @default.
- W2014536060 hasRelatedWork W1998163972 @default.
- W2014536060 hasRelatedWork W2021262052 @default.
- W2014536060 hasRelatedWork W2031374036 @default.
- W2014536060 hasRelatedWork W2049401545 @default.
- W2014536060 hasRelatedWork W2079817251 @default.
- W2014536060 hasRelatedWork W2117462238 @default.
- W2014536060 hasRelatedWork W2131433114 @default.
- W2014536060 hasRelatedWork W2398749734 @default.
- W2014536060 hasRelatedWork W2415630758 @default.
- W2014536060 hasRelatedWork W2417974274 @default.
- W2014536060 hasRelatedWork W2421969895 @default.
- W2014536060 hasRelatedWork W2468050815 @default.
- W2014536060 hasRelatedWork W2469979437 @default.
- W2014536060 hasRelatedWork W2730555022 @default.
- W2014536060 hasRelatedWork W3199499598 @default.
- W2014536060 hasRelatedWork W55736353 @default.
- W2014536060 isParatext "false" @default.
- W2014536060 isRetracted "false" @default.
- W2014536060 magId "2014536060" @default.
- W2014536060 workType "article" @default.