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• W2014536568 abstract "This study investigates the concentrations of inhibin in the bovine fetal ovary and testis throughout gestation (days 40 to 270/term) as determined by inhibin in vitro bioassay and RIA techniques. In addition, the expression of the inhibin a- and β-subunits (βA and βB) in these tissues was evaluated by Northern blot analysis and in situ hybridization. Testicular concentrations of inhibin bioactivity and immunoactivity increased 2.5-fold (103 ± 24.5 to 256 ± 11.7 U/g wet weight; mean ± SE) and 10.4-fold (139 ± 56 to 1430 ± 172) respectively, between 90 days and term. The corresponding ratio of inhibin biological: immunological activities (B/I ratio) decreased 8.3- fold (1.5 ± 0.7 to 0.18 ± 0.01). The concentration of ovarian bioactive inhibin increased significantly (P <0.05) 4.6-fold between 90 days and term (73.6 ± 14.7 to 340 ± 11.1 U/g wet weight), whereas the immunoactive inhibin concentration increased 10.3-fold between 120 and 210 days of gestation (7.2 ± 1.9 to 40.0 ± 8.7). The corresponding B/I ratio remained unchanged throughout gestation (8.3 ± 2.4 to 12.5 ± 4.0). Although the levels of a subunit mRNA in the testis and ovary increased over gestation, the levels of testicular βA subunit mRNA remained low and unchanged. Ovarian levels of /9A subunit mRNA were also low but variable. Furthermore, no /8B subunit mRNA could be detected in gonadal tissue throughout gestation. a-Subunit mRNA was detected by in situ hybridization in the sex cords of the fetal testis and the granulosa cells of the fetal ovary while βA subunit mRNA was detected only in the granulosa cells of the fetal ovary. It is concluded that inhibin is produced by the fetal testis and ovary and these tissue levels increase throughout gestation. The location of a- and βA-subunit mRNA to the sex cords of the testis and granulosa cells of the ovary indicate that these cells are the primary source of inhibin production. The rapid fall in inhibin B/I ratio in testicular extracts over gestation is attributed to the production of an inhibin-related protein with limited or negligible biological activity. (Endocrinology127: 2938–2946, 1990)" @default.
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• W2014536568 date "1990-12-01" @default.
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• W2014536568 title "<i>In Vitro</i>Bioactive and Immunoactive Inhibin Concentrations in Bovine Fetal Ovaries and Testes throughout Gestation*" @default.
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• W2014536568 doi "https://doi.org/10.1210/endo-127-6-2938" @default.
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