Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014539461> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2014539461 endingPage "543" @default.
- W2014539461 startingPage "537" @default.
- W2014539461 abstract "Recent work has implicated the importance of adapter proteins in signal transduction. To identify homologues of the previously identified adapter protein Shb, database searches were performed. A Shb-like protein was found which we have named Shf. Shf contains an SH2 domain and four putative tyrosine phosphorylation sites and is mainly expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine, and colon. The SH2 domain of Shf bound to the PDGF-alpha-receptor at tyrosine-720, but not to the PDGF-beta-receptor in PAE cells. Pervanadate induced tyrosine phosphorylation of Shf in NIH3T3 fibroblasts overexpressing this protein, whereas PDGF-AA alone had no detectable effect. NIH3T3 cells overexpressing Shf displayed significantly lower rates of apoptosis than control cells in the presence of PDGF-AA. Our findings suggest a role for the novel adapter Shf in PDGF-receptor signaling and regulation of apoptosis." @default.
- W2014539461 created "2016-06-24" @default.
- W2014539461 creator A5004903799 @default.
- W2014539461 creator A5041457449 @default.
- W2014539461 creator A5053898303 @default.
- W2014539461 creator A5080862743 @default.
- W2014539461 date "2000-11-01" @default.
- W2014539461 modified "2023-10-09" @default.
- W2014539461 title "Shf, a Shb-like Adapter Protein, Is Involved in PDGF-α-Receptor Regulation of Apoptosis" @default.
- W2014539461 cites W1522402713 @default.
- W2014539461 cites W1965755966 @default.
- W2014539461 cites W1977674120 @default.
- W2014539461 cites W2045199547 @default.
- W2014539461 cites W2046351190 @default.
- W2014539461 cites W2057866456 @default.
- W2014539461 cites W2141916872 @default.
- W2014539461 cites W2165209574 @default.
- W2014539461 cites W2329979475 @default.
- W2014539461 doi "https://doi.org/10.1006/bbrc.2000.3847" @default.
- W2014539461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11095946" @default.
- W2014539461 hasPublicationYear "2000" @default.
- W2014539461 type Work @default.
- W2014539461 sameAs 2014539461 @default.
- W2014539461 citedByCount "29" @default.
- W2014539461 countsByYear W20145394612013 @default.
- W2014539461 countsByYear W20145394612014 @default.
- W2014539461 countsByYear W20145394612015 @default.
- W2014539461 countsByYear W20145394612016 @default.
- W2014539461 countsByYear W20145394612018 @default.
- W2014539461 countsByYear W20145394612022 @default.
- W2014539461 crossrefType "journal-article" @default.
- W2014539461 hasAuthorship W2014539461A5004903799 @default.
- W2014539461 hasAuthorship W2014539461A5041457449 @default.
- W2014539461 hasAuthorship W2014539461A5053898303 @default.
- W2014539461 hasAuthorship W2014539461A5080862743 @default.
- W2014539461 hasConcept C101544691 @default.
- W2014539461 hasConcept C119599485 @default.
- W2014539461 hasConcept C11960822 @default.
- W2014539461 hasConcept C127413603 @default.
- W2014539461 hasConcept C170493617 @default.
- W2014539461 hasConcept C177284502 @default.
- W2014539461 hasConcept C177917778 @default.
- W2014539461 hasConcept C180361614 @default.
- W2014539461 hasConcept C183786373 @default.
- W2014539461 hasConcept C185592680 @default.
- W2014539461 hasConcept C190283241 @default.
- W2014539461 hasConcept C197153747 @default.
- W2014539461 hasConcept C2775960820 @default.
- W2014539461 hasConcept C2776165026 @default.
- W2014539461 hasConcept C2777553839 @default.
- W2014539461 hasConcept C502942594 @default.
- W2014539461 hasConcept C55493867 @default.
- W2014539461 hasConcept C62478195 @default.
- W2014539461 hasConcept C86803240 @default.
- W2014539461 hasConcept C95444343 @default.
- W2014539461 hasConceptScore W2014539461C101544691 @default.
- W2014539461 hasConceptScore W2014539461C119599485 @default.
- W2014539461 hasConceptScore W2014539461C11960822 @default.
- W2014539461 hasConceptScore W2014539461C127413603 @default.
- W2014539461 hasConceptScore W2014539461C170493617 @default.
- W2014539461 hasConceptScore W2014539461C177284502 @default.
- W2014539461 hasConceptScore W2014539461C177917778 @default.
- W2014539461 hasConceptScore W2014539461C180361614 @default.
- W2014539461 hasConceptScore W2014539461C183786373 @default.
- W2014539461 hasConceptScore W2014539461C185592680 @default.
- W2014539461 hasConceptScore W2014539461C190283241 @default.
- W2014539461 hasConceptScore W2014539461C197153747 @default.
- W2014539461 hasConceptScore W2014539461C2775960820 @default.
- W2014539461 hasConceptScore W2014539461C2776165026 @default.
- W2014539461 hasConceptScore W2014539461C2777553839 @default.
- W2014539461 hasConceptScore W2014539461C502942594 @default.
- W2014539461 hasConceptScore W2014539461C55493867 @default.
- W2014539461 hasConceptScore W2014539461C62478195 @default.
- W2014539461 hasConceptScore W2014539461C86803240 @default.
- W2014539461 hasConceptScore W2014539461C95444343 @default.
- W2014539461 hasIssue "3" @default.
- W2014539461 hasLocation W20145394611 @default.
- W2014539461 hasLocation W20145394612 @default.
- W2014539461 hasOpenAccess W2014539461 @default.
- W2014539461 hasPrimaryLocation W20145394611 @default.
- W2014539461 hasRelatedWork W1985057592 @default.
- W2014539461 hasRelatedWork W1988890993 @default.
- W2014539461 hasRelatedWork W2031665308 @default.
- W2014539461 hasRelatedWork W2074198937 @default.
- W2014539461 hasRelatedWork W2076886801 @default.
- W2014539461 hasRelatedWork W2080520906 @default.
- W2014539461 hasRelatedWork W2082372390 @default.
- W2014539461 hasRelatedWork W2143261943 @default.
- W2014539461 hasRelatedWork W2266016739 @default.
- W2014539461 hasRelatedWork W2409756128 @default.
- W2014539461 hasVolume "278" @default.
- W2014539461 isParatext "false" @default.
- W2014539461 isRetracted "false" @default.
- W2014539461 magId "2014539461" @default.
- W2014539461 workType "article" @default.