Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014541024> ?p ?o ?g. }
- W2014541024 endingPage "158" @default.
- W2014541024 startingPage "152" @default.
- W2014541024 abstract "FRAT1 was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, which inhibits GSK-3-mediated phosphorylation of β-catenin and positively regulates the Wnt signaling pathway. FRAT1 has been identified as a proto-oncogene involved in tumorigenesis. Previous studies have shown that FRAT1 is strikingly overexpressed in some human cancers. However, the relationship between FRAT1 and human gliomas is unclear. In this study, we detected the expression of FRAT1 in human gliomas by immunohistochemistry, Western blot and RT-PCR. FRAT1 was found to be specifically expressed in the majority of glioma samples, and their expression levels increased markedly with the increase of WHO grades. In addition, there was a positive correlation between FRAT1 immunoreactivity score (IRS) and β-catenin IRS. Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy." @default.
- W2014541024 created "2016-06-24" @default.
- W2014541024 creator A5009018326 @default.
- W2014541024 creator A5026088053 @default.
- W2014541024 creator A5029538512 @default.
- W2014541024 creator A5029871478 @default.
- W2014541024 creator A5048727442 @default.
- W2014541024 creator A5056791564 @default.
- W2014541024 creator A5070959015 @default.
- W2014541024 creator A5074889378 @default.
- W2014541024 creator A5077232935 @default.
- W2014541024 creator A5079555269 @default.
- W2014541024 date "2010-03-01" @default.
- W2014541024 modified "2023-09-23" @default.
- W2014541024 title "The expression profile of FRAT1 in human gliomas" @default.
- W2014541024 cites W1905797098 @default.
- W2014541024 cites W1965174804 @default.
- W2014541024 cites W1965204519 @default.
- W2014541024 cites W1967803088 @default.
- W2014541024 cites W1971674000 @default.
- W2014541024 cites W1976874039 @default.
- W2014541024 cites W1989215255 @default.
- W2014541024 cites W1994252736 @default.
- W2014541024 cites W1995940184 @default.
- W2014541024 cites W2002659820 @default.
- W2014541024 cites W2008557163 @default.
- W2014541024 cites W2020866690 @default.
- W2014541024 cites W2024582693 @default.
- W2014541024 cites W2027286743 @default.
- W2014541024 cites W2031376430 @default.
- W2014541024 cites W2031753836 @default.
- W2014541024 cites W2036368737 @default.
- W2014541024 cites W2046904466 @default.
- W2014541024 cites W2053343244 @default.
- W2014541024 cites W2061170173 @default.
- W2014541024 cites W2069704514 @default.
- W2014541024 cites W2075319861 @default.
- W2014541024 cites W2080661409 @default.
- W2014541024 cites W2098802640 @default.
- W2014541024 cites W2107648723 @default.
- W2014541024 cites W2111436017 @default.
- W2014541024 cites W2119284420 @default.
- W2014541024 cites W2121685290 @default.
- W2014541024 cites W2135908086 @default.
- W2014541024 cites W2148893919 @default.
- W2014541024 cites W2151558240 @default.
- W2014541024 cites W2170296743 @default.
- W2014541024 cites W2239090104 @default.
- W2014541024 cites W2331190019 @default.
- W2014541024 doi "https://doi.org/10.1016/j.brainres.2010.01.037" @default.
- W2014541024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20096670" @default.
- W2014541024 hasPublicationYear "2010" @default.
- W2014541024 type Work @default.
- W2014541024 sameAs 2014541024 @default.
- W2014541024 citedByCount "20" @default.
- W2014541024 countsByYear W20145410242012 @default.
- W2014541024 countsByYear W20145410242013 @default.
- W2014541024 countsByYear W20145410242014 @default.
- W2014541024 countsByYear W20145410242015 @default.
- W2014541024 countsByYear W20145410242016 @default.
- W2014541024 countsByYear W20145410242018 @default.
- W2014541024 countsByYear W20145410242020 @default.
- W2014541024 countsByYear W20145410242022 @default.
- W2014541024 crossrefType "journal-article" @default.
- W2014541024 hasAuthorship W2014541024A5009018326 @default.
- W2014541024 hasAuthorship W2014541024A5026088053 @default.
- W2014541024 hasAuthorship W2014541024A5029538512 @default.
- W2014541024 hasAuthorship W2014541024A5029871478 @default.
- W2014541024 hasAuthorship W2014541024A5048727442 @default.
- W2014541024 hasAuthorship W2014541024A5056791564 @default.
- W2014541024 hasAuthorship W2014541024A5070959015 @default.
- W2014541024 hasAuthorship W2014541024A5074889378 @default.
- W2014541024 hasAuthorship W2014541024A5077232935 @default.
- W2014541024 hasAuthorship W2014541024A5079555269 @default.
- W2014541024 hasConcept C104317684 @default.
- W2014541024 hasConcept C121608353 @default.
- W2014541024 hasConcept C126322002 @default.
- W2014541024 hasConcept C137620995 @default.
- W2014541024 hasConcept C142724271 @default.
- W2014541024 hasConcept C204232928 @default.
- W2014541024 hasConcept C207886595 @default.
- W2014541024 hasConcept C2776415932 @default.
- W2014541024 hasConcept C2778227246 @default.
- W2014541024 hasConcept C2779324961 @default.
- W2014541024 hasConcept C2781018059 @default.
- W2014541024 hasConcept C29537977 @default.
- W2014541024 hasConcept C502942594 @default.
- W2014541024 hasConcept C55493867 @default.
- W2014541024 hasConcept C555283112 @default.
- W2014541024 hasConcept C62478195 @default.
- W2014541024 hasConcept C71924100 @default.
- W2014541024 hasConcept C86803240 @default.
- W2014541024 hasConcept C95444343 @default.
- W2014541024 hasConceptScore W2014541024C104317684 @default.
- W2014541024 hasConceptScore W2014541024C121608353 @default.
- W2014541024 hasConceptScore W2014541024C126322002 @default.
- W2014541024 hasConceptScore W2014541024C137620995 @default.
- W2014541024 hasConceptScore W2014541024C142724271 @default.