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- W2014546572 abstract "I read with great interest the recent article by Minhas et al. (2012). Withania may exert a number of anti-proliferative effects besides its protective role in SLE. Withaferin A and withanolide are both extracted from Withinia. Of these, withaferin A is the most potent though withanolide also exhibits growth inhibiting activity (Choudhary et al. 2010). These anti-proliferative effects are clearly seen in NCI-H460 lung cancer cell lines (Yadav et al. 2010). Similarly, when applied to lung cancer cell lines, Withania augments the anti-neoplastic effects of chemotherapeutic agents such as paclitaxel (Senthilnathan et al. 2006). Withania extracts appear to have an immunomodulatory effect and enhance paclitaxel-induced inhibition of cell proliferation. Witharin also appears to be a radio sensitizer as it increases radio sensitivity of tumors and thereby enhances the apoptotic effects of radiotherapy (Muralikrishnan et al. 2010). Withania extracts appear to inhibit proliferation in HCT-15 colon cancer cell lines. For instance, it attenuates azoxymethane-induced colon cancer by modulating the levels of immunoglobulins G, A, and M and by exerting direct anti-proliferative effects (Mathur et al. 2004). 1-oxo-5beta, 6beta-epoxy-witha-2-enolide derived from Withania root has shown efficacy in the management of ultraviolet-B-induced dermatological carcinomas (Devi et al. 1996). Withania also appears to play a role in chemoprevention of skin malignancies. For instance, extracts from Withania roots have been shown to prevent the development of 7,12-dimethylbenz[a]anthracene (DMBA)induced skin cancers (Prakash et al. 2002). The above examples clearly illustrate the anti-proliferative effects of Withania and the need for further studies in this regard." @default.
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- W2014546572 date "2012-12-08" @default.
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- W2014546572 title "Withania somnifera and its emerging anti-neoplastic effects" @default.
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- W2014546572 doi "https://doi.org/10.1007/s10787-012-0162-4" @default.
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