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- W2014546712 abstract "Our purpose was to better understand the mutual influence of cis -diamminedichloroplatinum (II) ( cis -DDP) and intercalating drugs in their interactions with DNA. The present study deals with the intercalating drug N-methyl-2,7-diazapyrenium (MDAP). Two sets of experiments have been performed. In one set, the reaction between cis -DDP and nucleic acid was carried out in the presence of MDAP. The main adduct is a guanine residue chelated by platinum to a MDAP residue. It has the same spectroscopic properties as the synthesized compound cis -[Pt (NH 3 ) 2 (N7-d-guanosine) (N7-MDAP)] +++ , the structure of which has been determined by 1 H NMR. This adduct was only formed with double-stranded nucleic acids which reveals the importance of DNA matrix in orienting favorably the reactants. In the second set of experiments, the triamine complex cis -[Pt(NH 3 ) 2 (MDAP)CI] ++ was reacted with the nucleic acids. At molar ratios drug over nucleotide residue equal or less than 0.10, all the added triamine complexes bind by covalent coordination to double-stranded nucleic acids. With natural DNA, the major adduct is cis -[Pt(NH 3 ) 2 (d-guanosine) (MDAP)] +++ . Thus the same adduct is formed on one hand in the reaction between DNA, MDAP and cis -DDP and on the other hand in the reaction between the triamine complex and DNA. The triamine complex offers the possibility to study the biological role of the new adduct." @default.
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- W2014546712 title "Formation of a DNA monofunctional<i>cis</i>-platinum adduct cross-linking the intercalating drug N-methyl-2, 7-diazapyrenium" @default.
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- W2014546712 doi "https://doi.org/10.1093/nar/18.13.3887" @default.
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