FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014547643> ?p ?o ?g. }

• W2014547643 endingPage "s132" @default.
• W2014547643 startingPage "s125" @default.
• W2014547643 abstract "The long-acting calcium antagonist nifedipine reduces the incidence of stroke in Eastern Asia, as shown by the Shanghai Trial Of Nifedipine in the Elderly (STONE) and the Systolic Hypertension in China (Syst-China) trials. Recent trials in Japan have shown that benidipine may be more efficient than the former drug in preventing strokes in the elderly. Benidipine, commonly prescribed in Japan for a definite depressor effect, reportedly without causing remarkable fluctuations in blood pressure (BP), is investigated herein from a chronobiological viewpoint. Eighteen subjects (nine women and nine men, 39 to 87 years of age) with essential hypertension (office and ambulatory systolic, S/diastolic, D BP values above 16095 mm Hg and 13080 mm Hg, respectively) were enrolled in this investigation. Ambulatory BP was monitored at 30-min intervals for at least 24 h (ABPM-630, Colin Medical) before and after 4 weeks of crossover treatment with nifedipine tablets (twice daily, 20 mg/d) and benidipine (once daily, 4 mg/d, in the morning). The results indicate that: 1) benidipine and nifedipine reduce 24-h daytime (10:00–20:00) and nighttime (00:00–06:00) averages of SBP and DBP (P < 0.001); 2) the circadian double amplitude of BP is decreased after treatment with benidipine (from 28.6 to 21.1 mm Hg SBP and from 19.7 to 15.2 mm Hg DBP; P < 0.05), while the day-night difference in SBP is increased after treatment with nifedipine (18.6 vs 27.9 mm Hg, P < 0.01); and 3) the increase in the day-night difference of heart rate (HR) is significant after treatment with benidipine (13.6 vs 18.8 beats per minute, bpm; P < 0.05), but not with nifedipine. We have previously evaluated the usefulness of the circadian amplitude of BP as a prognostic tool of cardiovascular outcome, and found that an excessive circadian SBP or DBP amplitude was associated with an increased risk of vascular disease. The fact that benidipine reduces the circadian BP amplitude may be one reason for the superiority of this treatment over nifedipine in preventing an adverse outcome. A reduced heart rate variability (HRV) also predicts adverse cardiovascular outcomes in patients with overt cardiovascular disease and in hypertensive subjects. The fact that benidipine increases the day-night difference in HR may be another reason for the positive effects of this treatment." @default.
• W2014547643 created "2016-06-24" @default.
• W2014547643 creator A5010061679 @default.
• W2014547643 creator A5040866668 @default.
• W2014547643 creator A5058766978 @default.
• W2014547643 creator A5078251094 @default.
• W2014547643 creator A5084325881 @default.
• W2014547643 creator A5089610679 @default.
• W2014547643 date "2000-11-01" @default.
• W2014547643 modified "2023-10-17" @default.
• W2014547643 title "Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke" @default.
• W2014547643 cites W1485660711 @default.
• W2014547643 cites W1969997152 @default.
• W2014547643 cites W1993078740 @default.
• W2014547643 cites W1994456813 @default.
• W2014547643 cites W2024099389 @default.
• W2014547643 cites W2027138177 @default.
• W2014547643 cites W2056350582 @default.
• W2014547643 cites W2071626971 @default.
• W2014547643 cites W2084446244 @default.
• W2014547643 cites W2116620721 @default.
• W2014547643 cites W2146315609 @default.
• W2014547643 cites W2285072859 @default.
• W2014547643 cites W2297753288 @default.
• W2014547643 cites W2318579539 @default.
• W2014547643 cites W2416538760 @default.
• W2014547643 cites W2508993259 @default.
• W2014547643 cites W2893548641 @default.
• W2014547643 doi "https://doi.org/10.1016/s0753-3322(01)90017-4" @default.
• W2014547643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11774859" @default.
• W2014547643 hasPublicationYear "2000" @default.
• W2014547643 type Work @default.
• W2014547643 sameAs 2014547643 @default.
• W2014547643 citedByCount "25" @default.
• W2014547643 countsByYear W20145476432012 @default.
• W2014547643 countsByYear W20145476432013 @default.
• W2014547643 countsByYear W20145476432014 @default.
• W2014547643 countsByYear W20145476432016 @default.
• W2014547643 countsByYear W20145476432019 @default.
• W2014547643 countsByYear W20145476432020 @default.
• W2014547643 countsByYear W20145476432021 @default.
• W2014547643 crossrefType "journal-article" @default.
• W2014547643 hasAuthorship W2014547643A5010061679 @default.
• W2014547643 hasAuthorship W2014547643A5040866668 @default.
• W2014547643 hasAuthorship W2014547643A5058766978 @default.
• W2014547643 hasAuthorship W2014547643A5078251094 @default.
• W2014547643 hasAuthorship W2014547643A5084325881 @default.
• W2014547643 hasAuthorship W2014547643A5089610679 @default.
• W2014547643 hasConcept C126322002 @default.
• W2014547643 hasConcept C127413603 @default.
• W2014547643 hasConcept C142724271 @default.
• W2014547643 hasConcept C149323552 @default.
• W2014547643 hasConcept C164705383 @default.
• W2014547643 hasConcept C19720800 @default.
• W2014547643 hasConcept C204787440 @default.
• W2014547643 hasConcept C27081682 @default.
• W2014547643 hasConcept C2779066535 @default.
• W2014547643 hasConcept C2780192228 @default.
• W2014547643 hasConcept C2780645631 @default.
• W2014547643 hasConcept C35785553 @default.
• W2014547643 hasConcept C519063684 @default.
• W2014547643 hasConcept C57900726 @default.
• W2014547643 hasConcept C71924100 @default.
• W2014547643 hasConcept C78519656 @default.
• W2014547643 hasConcept C84393581 @default.
• W2014547643 hasConcept C87813604 @default.
• W2014547643 hasConceptScore W2014547643C126322002 @default.
• W2014547643 hasConceptScore W2014547643C127413603 @default.
• W2014547643 hasConceptScore W2014547643C142724271 @default.
• W2014547643 hasConceptScore W2014547643C149323552 @default.
• W2014547643 hasConceptScore W2014547643C164705383 @default.
• W2014547643 hasConceptScore W2014547643C19720800 @default.
• W2014547643 hasConceptScore W2014547643C204787440 @default.
• W2014547643 hasConceptScore W2014547643C27081682 @default.
• W2014547643 hasConceptScore W2014547643C2779066535 @default.
• W2014547643 hasConceptScore W2014547643C2780192228 @default.
• W2014547643 hasConceptScore W2014547643C2780645631 @default.
• W2014547643 hasConceptScore W2014547643C35785553 @default.
• W2014547643 hasConceptScore W2014547643C519063684 @default.
• W2014547643 hasConceptScore W2014547643C57900726 @default.
• W2014547643 hasConceptScore W2014547643C71924100 @default.
• W2014547643 hasConceptScore W2014547643C78519656 @default.
• W2014547643 hasConceptScore W2014547643C84393581 @default.
• W2014547643 hasConceptScore W2014547643C87813604 @default.
• W2014547643 hasLocation W20145476431 @default.
• W2014547643 hasLocation W20145476432 @default.
• W2014547643 hasOpenAccess W2014547643 @default.
• W2014547643 hasPrimaryLocation W20145476431 @default.
• W2014547643 hasRelatedWork W2006109139 @default.
• W2014547643 hasRelatedWork W2097067662 @default.
• W2014547643 hasRelatedWork W2113996657 @default.
• W2014547643 hasRelatedWork W2348373160 @default.
• W2014547643 hasRelatedWork W2356039309 @default.
• W2014547643 hasRelatedWork W2361425134 @default.
• W2014547643 hasRelatedWork W2371195870 @default.
• W2014547643 hasRelatedWork W2399977284 @default.
• W2014547643 hasRelatedWork W2953225176 @default.
• W2014547643 hasRelatedWork W4379800651 @default.

• next