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• W2014548236 abstract "Intracellular cargo transport uses a combination of dynein and kinesin motors to traverse along microtubule filaments in cells. It has been demonstrated that the motion of cargo within a complex network of microtubules in live cells can be viewed as a hindered random walk with correlation in the step size and dwell times of successive steps (Tabei 2012). A mean zero random walk is surprising considering that these processes are used for directed, unidirectional transport in cells. Further, the individual microtubules within the network are dynamic and the network is constantly changing. Although recent enlightening models have revealed that the motion in cells can be well-described by a subordinated random walk, the combination of fundamental components for the molecular mechanism are complex and still unknown. In order to better inform these models about the activity of single motors within the network, we perform well-defined systematic experiments of processive motors on anti-parallel or randomly-oriented filament bundles. Antiparallel bundles are created using MAP65 to crosslink microtubules. Randomly-oriented bundles are created using depletion forces from inert poly-ethylene glycol molecules in solution. We find that, kinesin motors can reverse direction and exhibit random-walk like behavior when transitioning between microtubules within in the bundle at long times." @default.
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• W2014548236 date "2014-01-01" @default.
• W2014548236 modified "2023-10-17" @default.
• W2014548236 title "Single Motor Random Walks on Microtubule Bundles" @default.
• W2014548236 doi "https://doi.org/10.1016/j.bpj.2013.11.4294" @default.
• W2014548236 hasPublicationYear "2014" @default.
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