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- W2014549178 abstract "Neurite extension and branching are important neuronal plasticity mechanisms that can lead to the addition of synaptic contacts in developing neurons and changes in the number of synapses in mature neurons. Here we show that Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates movement, extension, and branching of filopodia and fine dendrites as well as the number of synapses in hippocampal neurons. Only CaMKIIbeta, which peaks in expression early in development, but not CaMKIIalpha, has this morphogenic activity. A small insert in CaMKIIbeta, which is absent in CaMKIIalpha, confers regulated F-actin localization to the enzyme and enables selective upregulation of dendritic motility. These results show that the two main neuronal CaMKII isoforms have markedly different roles in neuronal plasticity, with CaMKIIalpha regulating synaptic strength and CaMKIIbeta controlling the dendritic morphology and number of synapses." @default.
- W2014549178 created "2016-06-24" @default.
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- W2014549178 date "2003-07-01" @default.
- W2014549178 modified "2023-10-12" @default.
- W2014549178 title "Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII" @default.
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- W2014549178 doi "https://doi.org/10.1016/s0896-6273(03)00428-8" @default.
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