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- W2014549771 abstract "Abstract The purpose of this report is to describe an immunohistological method for detection of proliferating cell nuclear antigen (PCNA/cyclin) in formaldehyde-fixed and paraffin-embedded liver tissue and to clarify the effects of formaldehyde fixation on antigenicity of PCNA/cyclin. For the immunohistological investigation, 34 cases (11 hepatocellular carcinoma, 8 liver cirrhosis, 15 chronic hepatitis) of human liver biopsy specimens were stained by the avidin-biotin peroxidase complex (ABC) method using a commercially available monoclonal anti-PCNA/cyclin antibody (Mab, 19A2). The PCNA/cyclin-positive nuclei of normal or transformed hepatocytes were detected in 11 cases of hepatocellular carcinoma (100%), 7 cases of liver cirrhosis (87.5%) and 12 cases of chronic hepatitis (80%). Various formaldehyde fixation conditions were examined for the regenerative rat liver by changing formaldehyde concentration, fixation time and time interval from resection to fixation. In conclusion, we have found that PCNA/cyclin-positive cell rate of the liver was stabilized within the first 7 days of the fixation. These results suggested that an immunohistological method with anti-PCNA/cyclin antibody might be useful for the routine cell kinetic analysis of the liver." @default.
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- W2014549771 date "1993-05-15" @default.
- W2014549771 modified "2023-09-26" @default.
- W2014549771 title "Immunohistological detection of PCNA/cyclin in paraffin-embedded liver tissue" @default.
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- W2014549771 doi "https://doi.org/10.1016/0928-4346(93)90055-k" @default.
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