Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014549820> ?p ?o ?g. }
- W2014549820 endingPage "1100" @default.
- W2014549820 startingPage "1095" @default.
- W2014549820 abstract "Long-lived subjects have been shown to have peculiar anthropometric features (i.e. lower body mass index (BMI)) and metabolic parameters (i.e. improved insulin sensitivity). Life style and a genetic background potentially protective against the age-related metabolic derangement might contribute to such a particular phenotype. Peroxisome proliferator-activated receptor (PPAR)gamma-2 is an important regulator of adipose tissue metabolism, insulin sensitivity and inflammatory response. Thus, the potential role of genetic variability at Pro/Ala loci of PPARG gene on longevity was studied in 222 long-lived subjects and 250 aged subjects. We found a different Pro/Ala genotype frequency distribution between long-lived and aged men subjects, long-lived men having an increased frequency of Pro/Ala genotype (20 vs 8.5%); no differences was found when allele and genotype distribution of Pro/Ala gene polymorphism were analyzed in the two age group of women. Interestingly, subjects with Pro/Ala polymorphism had significantly lower BMI than Ala/Ala and Pro/Pro polymorphism. In conclusion, our study demonstrated that paraoxonase Pro/Ala gene polyporphism is associated with human longevity. Such an effect is probably due to the effect of Pro/Ala polymorphism on body composition and appears to be gender specific." @default.
- W2014549820 created "2016-06-24" @default.
- W2014549820 creator A5001101425 @default.
- W2014549820 creator A5002840335 @default.
- W2014549820 creator A5004686163 @default.
- W2014549820 creator A5030785284 @default.
- W2014549820 creator A5054868676 @default.
- W2014549820 creator A5068861596 @default.
- W2014549820 creator A5078302741 @default.
- W2014549820 creator A5084616356 @default.
- W2014549820 date "2004-07-01" @default.
- W2014549820 modified "2023-10-18" @default.
- W2014549820 title "Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)γ-2 with longevity" @default.
- W2014549820 cites W1527649416 @default.
- W2014549820 cites W1633340712 @default.
- W2014549820 cites W1647126819 @default.
- W2014549820 cites W1917926680 @default.
- W2014549820 cites W1972779452 @default.
- W2014549820 cites W1973110215 @default.
- W2014549820 cites W1974109692 @default.
- W2014549820 cites W1983128420 @default.
- W2014549820 cites W1989247943 @default.
- W2014549820 cites W1996256476 @default.
- W2014549820 cites W1997130090 @default.
- W2014549820 cites W1998887769 @default.
- W2014549820 cites W1999898110 @default.
- W2014549820 cites W2012507063 @default.
- W2014549820 cites W2016932058 @default.
- W2014549820 cites W2026701971 @default.
- W2014549820 cites W2028654782 @default.
- W2014549820 cites W2028661874 @default.
- W2014549820 cites W2038686627 @default.
- W2014549820 cites W2042694949 @default.
- W2014549820 cites W2045649324 @default.
- W2014549820 cites W2045989280 @default.
- W2014549820 cites W2069863984 @default.
- W2014549820 cites W2086043350 @default.
- W2014549820 cites W2086376157 @default.
- W2014549820 cites W2094129019 @default.
- W2014549820 cites W2106617467 @default.
- W2014549820 cites W2108272986 @default.
- W2014549820 cites W2108514903 @default.
- W2014549820 cites W2108971974 @default.
- W2014549820 cites W2111037990 @default.
- W2014549820 cites W2119535026 @default.
- W2014549820 cites W2123836596 @default.
- W2014549820 cites W2125344994 @default.
- W2014549820 cites W2132102439 @default.
- W2014549820 cites W2134293572 @default.
- W2014549820 cites W2137048190 @default.
- W2014549820 cites W2139292825 @default.
- W2014549820 cites W2149913162 @default.
- W2014549820 cites W2150557496 @default.
- W2014549820 cites W2157764447 @default.
- W2014549820 cites W2160234571 @default.
- W2014549820 cites W2169224393 @default.
- W2014549820 cites W2318145197 @default.
- W2014549820 cites W2333284976 @default.
- W2014549820 cites W4237975609 @default.
- W2014549820 cites W4246241479 @default.
- W2014549820 doi "https://doi.org/10.1016/j.exger.2004.03.034" @default.
- W2014549820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15236769" @default.
- W2014549820 hasPublicationYear "2004" @default.
- W2014549820 type Work @default.
- W2014549820 sameAs 2014549820 @default.
- W2014549820 citedByCount "53" @default.
- W2014549820 countsByYear W20145498202012 @default.
- W2014549820 countsByYear W20145498202013 @default.
- W2014549820 countsByYear W20145498202014 @default.
- W2014549820 countsByYear W20145498202015 @default.
- W2014549820 countsByYear W20145498202016 @default.
- W2014549820 countsByYear W20145498202018 @default.
- W2014549820 countsByYear W20145498202019 @default.
- W2014549820 countsByYear W20145498202020 @default.
- W2014549820 countsByYear W20145498202021 @default.
- W2014549820 countsByYear W20145498202023 @default.
- W2014549820 crossrefType "journal-article" @default.
- W2014549820 hasAuthorship W2014549820A5001101425 @default.
- W2014549820 hasAuthorship W2014549820A5002840335 @default.
- W2014549820 hasAuthorship W2014549820A5004686163 @default.
- W2014549820 hasAuthorship W2014549820A5030785284 @default.
- W2014549820 hasAuthorship W2014549820A5054868676 @default.
- W2014549820 hasAuthorship W2014549820A5068861596 @default.
- W2014549820 hasAuthorship W2014549820A5078302741 @default.
- W2014549820 hasAuthorship W2014549820A5084616356 @default.
- W2014549820 hasConcept C104317684 @default.
- W2014549820 hasConcept C126322002 @default.
- W2014549820 hasConcept C127716648 @default.
- W2014549820 hasConcept C134018914 @default.
- W2014549820 hasConcept C135763542 @default.
- W2014549820 hasConcept C149737253 @default.
- W2014549820 hasConcept C170493617 @default.
- W2014549820 hasConcept C171089720 @default.
- W2014549820 hasConcept C180754005 @default.
- W2014549820 hasConcept C187345961 @default.
- W2014549820 hasConcept C2776759703 @default.
- W2014549820 hasConcept C37463918 @default.
- W2014549820 hasConcept C54355233 @default.