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• W2014555734 abstract "N 1 -meA and N 3 -meC are cytotoxic DNA base methylation lesions that can accumulate in the genomes of various organisms in the presence of S N 2 type methylating agents. We report here the structural characterization of these base lesions in duplex DNA using a cross-linked protein–DNA crystallization system. The crystal structure of N 1 -meA:T pair shows an unambiguous Hoogsteen base pair with a syn conformation adopted by N 1 -meA, which exhibits significant changes in the opening, roll and twist angles as compared to the normal A:T base pair. Unlike N 1 -meA, N 3 -meC does not establish any interaction with the opposite G, but remains partially intrahelical. Also, structurally characterized is the N 6 -meA base modification that forms a normal base pair with the opposite T in duplex DNA. Structural characterization of these base methylation modifications provides molecular level information on how they affect the overall structure of duplex DNA. In addition, the base pairs containing N 1 -meA or N 3 -meC do not share any specific characteristic properties except that both lesions create thermodynamically unstable regions in a duplex DNA, a property that may be explored by the repair proteins to locate these lesions." @default.
• W2014555734 created "2016-06-24" @default.
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• W2014555734 date "2010-03-11" @default.
• W2014555734 modified "2023-10-16" @default.
• W2014555734 title "Structure determination of DNA methylation lesions N 1 -meA and N 3 -meC in duplex DNA using a cross-linked protein–DNA system" @default.
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• W2014555734 doi "https://doi.org/10.1093/nar/gkq129" @default.
• W2014555734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2910035" @default.
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