FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014559152> ?p ?o ?g. }

• W2014559152 endingPage "130" @default.
• W2014559152 startingPage "112" @default.
• W2014559152 abstract "Developing novel therapeutics and diagnostic tools based upon an understanding of neuroplasticity is critical in order to improve the treatment and ultimately the prevention of a broad range of nervous system disorders. In the case of mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), where diagnoses are based solely on nosology rather than pathophysiology, there exists a clear unmet medical need to advance our understanding of the underlying molecular mechanisms and to develop fundamentally new mechanism experimental medicines with improved efficacy. In this context, recent preclinical molecular, cellular, and behavioral findings have begun to reveal the importance of epigenetic mechanisms that alter chromatin structure and dynamically regulate patterns of gene expression that may play a critical role in the pathophysiology of mood disorders. Here, we will review recent advances involving the use of animal models in combination with genetic and pharmacological probes to dissect the underlying molecular mechanisms and neurobiological consequence of targeting this chromatin-mediated neuroplasticity. We discuss evidence for the direct and indirect effects of mood stabilizers, antidepressants, and antipsychotics, among their many other effects, on chromatin-modifying enzymes and on the epigenetic state of defined genomic loci, in defined cell types and in specific regions of the brain. These data, as well as findings from patient-derived tissue, have also begun to reveal alterations of epigenetic mechanisms in the pathophysiology and treatment of mood disorders. We summarize growing evidence supporting the notion that selectively targeting chromatin-modifying complexes, including those containing histone deacetylases (HDACs), provides a means to reversibly alter the acetylation state of neuronal chromatin and beneficially impact neuronal activity-regulated gene transcription and mood-related behaviors. Looking beyond current knowledge, we discuss how high-resolution, whole-genome methodologies, such as RNA-sequencing (RNA-Seq) for transcriptome analysis and chromatin immunoprecipitation-sequencing (ChIP-Seq) for analyzing genome-wide occupancy of chromatin-associated factors, are beginning to provide an unprecedented view of both specific genomic loci as well as global properties of chromatin in the nervous system. These methodologies when applied to the characterization of model systems, including those of patient-derived induced pluripotent cell (iPSC) and induced neurons (iNs), will greatly shape our understanding of epigenetic mechanisms and the impact of genetic variation on the regulatory regions of the human genome that can affect neuroplasticity. Finally, we point out critical unanswered questions and areas where additional data are needed in order to better understand the potential to target mechanisms of chromatin-mediated neuroplasticity for novel treatments of mood and other psychiatric disorders." @default.
• W2014559152 created "2016-06-24" @default.
• W2014559152 creator A5014078683 @default.
• W2014559152 creator A5064278484 @default.
• W2014559152 creator A5080836726 @default.
• W2014559152 creator A5082252371 @default.
• W2014559152 date "2014-04-01" @default.
• W2014559152 modified "2023-10-01" @default.
• W2014559152 title "Epigenetic mechanisms in mood disorders: Targeting neuroplasticity" @default.
• W2014559152 cites W1539151695 @default.
• W2014559152 cites W1560970226 @default.
• W2014559152 cites W1645800103 @default.
• W2014559152 cites W1963736896 @default.
• W2014559152 cites W1966171594 @default.
• W2014559152 cites W1971334707 @default.
• W2014559152 cites W1971637333 @default.
• W2014559152 cites W1971725498 @default.
• W2014559152 cites W1972943884 @default.
• W2014559152 cites W1974631163 @default.
• W2014559152 cites W1974849634 @default.
• W2014559152 cites W1976507388 @default.
• W2014559152 cites W1977252830 @default.
• W2014559152 cites W1978891587 @default.
• W2014559152 cites W1979187818 @default.
• W2014559152 cites W1983532163 @default.
• W2014559152 cites W1985675810 @default.
• W2014559152 cites W1993138135 @default.
• W2014559152 cites W1993588417 @default.
• W2014559152 cites W1994759548 @default.
• W2014559152 cites W1994994441 @default.
• W2014559152 cites W1995358122 @default.
• W2014559152 cites W1996116694 @default.
• W2014559152 cites W1998630992 @default.
• W2014559152 cites W1999141289 @default.
• W2014559152 cites W2000388202 @default.
• W2014559152 cites W2000500943 @default.
• W2014559152 cites W2000855271 @default.
• W2014559152 cites W2003410380 @default.
• W2014559152 cites W2004160166 @default.
• W2014559152 cites W2005689612 @default.
• W2014559152 cites W2005744880 @default.
• W2014559152 cites W2009132775 @default.
• W2014559152 cites W2009826707 @default.
• W2014559152 cites W2010308368 @default.
• W2014559152 cites W2015398239 @default.
• W2014559152 cites W2018021093 @default.
• W2014559152 cites W2020654785 @default.
• W2014559152 cites W2020833075 @default.
• W2014559152 cites W2021814667 @default.
• W2014559152 cites W2022818353 @default.
• W2014559152 cites W2024274395 @default.
• W2014559152 cites W2024357198 @default.
• W2014559152 cites W2025326800 @default.
• W2014559152 cites W2028449397 @default.
• W2014559152 cites W2028679671 @default.
• W2014559152 cites W2032322067 @default.
• W2014559152 cites W2032882684 @default.
• W2014559152 cites W2035421865 @default.
• W2014559152 cites W2042944469 @default.
• W2014559152 cites W2042966900 @default.
• W2014559152 cites W2044347158 @default.
• W2014559152 cites W2046244011 @default.
• W2014559152 cites W2046459630 @default.
• W2014559152 cites W2048834720 @default.
• W2014559152 cites W2051089184 @default.
• W2014559152 cites W2052373759 @default.
• W2014559152 cites W2052714177 @default.
• W2014559152 cites W2053591294 @default.
• W2014559152 cites W2054017008 @default.
• W2014559152 cites W2054444927 @default.
• W2014559152 cites W2054513544 @default.
• W2014559152 cites W2056531552 @default.
• W2014559152 cites W2057437339 @default.
• W2014559152 cites W2059115988 @default.
• W2014559152 cites W2061095064 @default.
• W2014559152 cites W2061095991 @default.
• W2014559152 cites W2062534208 @default.
• W2014559152 cites W2062740397 @default.
• W2014559152 cites W2064804693 @default.
• W2014559152 cites W2065289461 @default.
• W2014559152 cites W2065561114 @default.
• W2014559152 cites W2067821921 @default.
• W2014559152 cites W2069164541 @default.
• W2014559152 cites W2070029284 @default.
• W2014559152 cites W2070357895 @default.
• W2014559152 cites W2071984705 @default.
• W2014559152 cites W2073482315 @default.
• W2014559152 cites W2074489888 @default.
• W2014559152 cites W2078600569 @default.
• W2014559152 cites W2079406514 @default.
• W2014559152 cites W2081302124 @default.
• W2014559152 cites W2081351662 @default.
• W2014559152 cites W2083784041 @default.
• W2014559152 cites W2085038833 @default.
• W2014559152 cites W2087246624 @default.
• W2014559152 cites W2090760765 @default.
• W2014559152 cites W2094627293 @default.
• W2014559152 cites W2096514794 @default.

• next