Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014560862> ?p ?o ?g. }
- W2014560862 endingPage "726" @default.
- W2014560862 startingPage "716" @default.
- W2014560862 abstract "We evaluated the suitability of the Friend Virus (FV) model for the development of improved adenovirus vectors for anti-retroviral vaccination using two types of adenovirus vectors, encoding F-MuLV Env and Gag, which differed only in their fiber genes (Ad5 and Ad5F35). Genetically FV-resistant C57BL/6 mice and highly susceptible CB6F1 hybrid mice were vaccinated by either homologous or heterologous prime-boost regimen. After FV challenge, viral loads in the spleens of C57BL/6 mice were reduced approximately 250-fold and were below the detection threshold in >50% of the mice. Vaccination outcome was critically influenced by the route of vector administration. In CB6F1 mice, vaccination resulted in reduced viremia, delayed onset of splenomegaly, and induction of FV-specific T cells as assessed by tetramer staining. Heterologous prime-boost vaccination resulted in significantly higher neutralizing antibody titers, translating into improved immune protection, in contrast to coexpression of cytokines. Our results suggest that the FV model can provide insight into the development of improved adenovirus vectors for HIV-1 vaccination." @default.
- W2014560862 created "2016-06-24" @default.
- W2014560862 creator A5016243200 @default.
- W2014560862 creator A5016679171 @default.
- W2014560862 creator A5037629811 @default.
- W2014560862 creator A5044263312 @default.
- W2014560862 creator A5070487295 @default.
- W2014560862 date "2008-01-01" @default.
- W2014560862 modified "2023-09-23" @default.
- W2014560862 title "Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies" @default.
- W2014560862 cites W1537314431 @default.
- W2014560862 cites W1540062552 @default.
- W2014560862 cites W1543325210 @default.
- W2014560862 cites W1596453268 @default.
- W2014560862 cites W1606226434 @default.
- W2014560862 cites W1629735417 @default.
- W2014560862 cites W1900471667 @default.
- W2014560862 cites W1924636867 @default.
- W2014560862 cites W1964800378 @default.
- W2014560862 cites W1976163997 @default.
- W2014560862 cites W1980682636 @default.
- W2014560862 cites W1992827681 @default.
- W2014560862 cites W1998545531 @default.
- W2014560862 cites W1998987175 @default.
- W2014560862 cites W2001118017 @default.
- W2014560862 cites W2004192724 @default.
- W2014560862 cites W2015324997 @default.
- W2014560862 cites W2015821234 @default.
- W2014560862 cites W2019757058 @default.
- W2014560862 cites W2025768863 @default.
- W2014560862 cites W2027421255 @default.
- W2014560862 cites W2029043430 @default.
- W2014560862 cites W2041449176 @default.
- W2014560862 cites W2046782578 @default.
- W2014560862 cites W2047006559 @default.
- W2014560862 cites W2075928272 @default.
- W2014560862 cites W2079730082 @default.
- W2014560862 cites W2081580748 @default.
- W2014560862 cites W2092235636 @default.
- W2014560862 cites W2095040060 @default.
- W2014560862 cites W2097892141 @default.
- W2014560862 cites W2098264302 @default.
- W2014560862 cites W2102032120 @default.
- W2014560862 cites W2102084617 @default.
- W2014560862 cites W2103182811 @default.
- W2014560862 cites W2113539556 @default.
- W2014560862 cites W2114071338 @default.
- W2014560862 cites W2120402476 @default.
- W2014560862 cites W2120721384 @default.
- W2014560862 cites W2120931274 @default.
- W2014560862 cites W2125556458 @default.
- W2014560862 cites W2126626052 @default.
- W2014560862 cites W2135698322 @default.
- W2014560862 cites W2136347300 @default.
- W2014560862 cites W2136567338 @default.
- W2014560862 cites W2141542838 @default.
- W2014560862 cites W2142579851 @default.
- W2014560862 cites W2145977702 @default.
- W2014560862 cites W2148123079 @default.
- W2014560862 cites W2151338681 @default.
- W2014560862 cites W2152856116 @default.
- W2014560862 cites W2153976288 @default.
- W2014560862 cites W2155155815 @default.
- W2014560862 cites W2156829792 @default.
- W2014560862 cites W2165366703 @default.
- W2014560862 cites W2178247330 @default.
- W2014560862 cites W4253422011 @default.
- W2014560862 doi "https://doi.org/10.1016/j.vaccine.2007.11.050" @default.
- W2014560862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18160188" @default.
- W2014560862 hasPublicationYear "2008" @default.
- W2014560862 type Work @default.
- W2014560862 sameAs 2014560862 @default.
- W2014560862 citedByCount "21" @default.
- W2014560862 countsByYear W20145608622012 @default.
- W2014560862 countsByYear W20145608622013 @default.
- W2014560862 countsByYear W20145608622014 @default.
- W2014560862 countsByYear W20145608622017 @default.
- W2014560862 countsByYear W20145608622019 @default.
- W2014560862 countsByYear W20145608622021 @default.
- W2014560862 countsByYear W20145608622022 @default.
- W2014560862 crossrefType "journal-article" @default.
- W2014560862 hasAuthorship W2014560862A5016243200 @default.
- W2014560862 hasAuthorship W2014560862A5016679171 @default.
- W2014560862 hasAuthorship W2014560862A5037629811 @default.
- W2014560862 hasAuthorship W2014560862A5044263312 @default.
- W2014560862 hasAuthorship W2014560862A5070487295 @default.
- W2014560862 hasConcept C104317684 @default.
- W2014560862 hasConcept C111599444 @default.
- W2014560862 hasConcept C159047783 @default.
- W2014560862 hasConcept C159654299 @default.
- W2014560862 hasConcept C203014093 @default.
- W2014560862 hasConcept C22070199 @default.
- W2014560862 hasConcept C2522874641 @default.
- W2014560862 hasConcept C2776185481 @default.
- W2014560862 hasConcept C2776954459 @default.
- W2014560862 hasConcept C2779261636 @default.
- W2014560862 hasConcept C2780115692 @default.
- W2014560862 hasConcept C32470452 @default.