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- W2014564564 abstract "In 9 asthmatic patients log(dose)-response curves were obtained on 4 successive days with the Wiesbadener Doppelinhalator (WDI) and the De Vilbiss (De V) 645 nebulizer, respectively. log(dose)-response was expressed as a quadratic regression equation. From those equations the dose, causing a fall in response (FEV1) of 10% of the initial value, was obtained and defined as the provocative concentration (PC(10] or sensitivity. Moreover, the reactivity was defined as the slope of the linear regression through the steeper part of the curve. Although we compared the De V and the WDI log(dose)-response curves after correction for the different liquid output, a significantly greater sensitivity was found for the De V nebulizer. As to the reactivity, no significant differences were found. The difference in sensitivity could perhaps be explained by the fact that, as compared with the De V nebulizer, the WDI may cause a larger deposition of aerosol on the throat and the pharynx, due to the much greater linear velocity of its aerosol jet." @default.
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- W2014564564 date "1985-01-01" @default.
- W2014564564 modified "2023-10-05" @default.
- W2014564564 title "Histamine log(dose)-Response Curves in Asthmatics" @default.
- W2014564564 doi "https://doi.org/10.1159/000194783" @default.
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