FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014570087> ?p ?o ?g. }

• W2014570087 endingPage "139" @default.
• W2014570087 startingPage "133" @default.
• W2014570087 abstract "Mammalian cells often use the highly conserved mitogen-activated protein kinase (MAPK) or extracellular signal regulated protein kinase (ERK) cascades to transmit intracellular instructions. These signaling pathways have been proposed to regulate a diverse range of biological functions including apoptosis. Since 2-methoxyestradiol (2ME) and prostaglandin A2 (PGA2) play an active role in the induction of apoptosis, the influence of 1 μM 2ME or 20 μg/ml PGA2 was investigated on ERK1/2 expression levels in three cancer cell lines. PGA2 exposure led to a statistically significant increase in ERK1/2 expression levels of HeLa and WHCO3 cells. In contrast to the HeLa and WHCO3 cancer cell lines, no effect on ERK1/2 expression levels was observed after exposure of PGA2 to MCF-7 cells. 2ME caused a statistically significant increase in ERK1/2 expression levels in HeLa, MCF-7 and WHCO3 cells. WHCO3 cells were shown to be more susceptible to the effects of PGA2 and 2ME compared to the other two cancer cell lines. Since the characteristics of both PGA2 and 2ME render them as possible anti-tumor agents when compared to conventional chemotherapeutic treatments, understanding the functional role of signaling events and their regulation by interfering pathways after exposure of cells to PGA2 and 2ME respectively, will provide new insights into mechanisms involved in malignant cell proliferation." @default.
• W2014570087 created "2016-06-24" @default.
• W2014570087 creator A5004332656 @default.
• W2014570087 creator A5010270064 @default.
• W2014570087 creator A5045288794 @default.
• W2014570087 date "2004-01-01" @default.
• W2014570087 modified "2023-10-16" @default.
• W2014570087 title "Influence of prostaglandin A2 and 2-methoxyestradiol on mitogen-activated protein kinase (MAPK) expression levels in malignant cell lines" @default.
• W2014570087 cites W1932499969 @default.
• W2014570087 cites W1964730992 @default.
• W2014570087 cites W1970493411 @default.
• W2014570087 cites W1970708444 @default.
• W2014570087 cites W1970825176 @default.
• W2014570087 cites W1979252983 @default.
• W2014570087 cites W1981813507 @default.
• W2014570087 cites W1983094501 @default.
• W2014570087 cites W1987500790 @default.
• W2014570087 cites W1989265374 @default.
• W2014570087 cites W1993657069 @default.
• W2014570087 cites W1995455205 @default.
• W2014570087 cites W1998948981 @default.
• W2014570087 cites W2000188603 @default.
• W2014570087 cites W2004141049 @default.
• W2014570087 cites W2007896773 @default.
• W2014570087 cites W2013142209 @default.
• W2014570087 cites W2016492849 @default.
• W2014570087 cites W2032615620 @default.
• W2014570087 cites W2036364900 @default.
• W2014570087 cites W2047263793 @default.
• W2014570087 cites W2064194470 @default.
• W2014570087 cites W2065308949 @default.
• W2014570087 cites W2075104267 @default.
• W2014570087 cites W2077795292 @default.
• W2014570087 cites W2082465552 @default.
• W2014570087 cites W2084849235 @default.
• W2014570087 cites W2102073771 @default.
• W2014570087 cites W2105421288 @default.
• W2014570087 cites W2129028245 @default.
• W2014570087 cites W2132734432 @default.
• W2014570087 cites W2146572998 @default.
• W2014570087 cites W2146736698 @default.
• W2014570087 cites W2187963245 @default.
• W2014570087 cites W2252391056 @default.
• W2014570087 cites W2404061373 @default.
• W2014570087 cites W2019621874 @default.
• W2014570087 doi "https://doi.org/10.2220/biomedres.25.133" @default.
• W2014570087 hasPublicationYear "2004" @default.
• W2014570087 type Work @default.
• W2014570087 sameAs 2014570087 @default.
• W2014570087 citedByCount "3" @default.
• W2014570087 crossrefType "journal-article" @default.
• W2014570087 hasAuthorship W2014570087A5004332656 @default.
• W2014570087 hasAuthorship W2014570087A5010270064 @default.
• W2014570087 hasAuthorship W2014570087A5045288794 @default.
• W2014570087 hasBestOaLocation W20145700871 @default.
• W2014570087 hasConcept C184235292 @default.
• W2014570087 hasConcept C190283241 @default.
• W2014570087 hasConcept C2777366897 @default.
• W2014570087 hasConcept C28406088 @default.
• W2014570087 hasConcept C502942594 @default.
• W2014570087 hasConcept C54355233 @default.
• W2014570087 hasConcept C55493867 @default.
• W2014570087 hasConcept C57074206 @default.
• W2014570087 hasConcept C62112901 @default.
• W2014570087 hasConcept C62478195 @default.
• W2014570087 hasConcept C79879829 @default.
• W2014570087 hasConcept C81885089 @default.
• W2014570087 hasConcept C86803240 @default.
• W2014570087 hasConcept C95444343 @default.
• W2014570087 hasConcept C97029542 @default.
• W2014570087 hasConceptScore W2014570087C184235292 @default.
• W2014570087 hasConceptScore W2014570087C190283241 @default.
• W2014570087 hasConceptScore W2014570087C2777366897 @default.
• W2014570087 hasConceptScore W2014570087C28406088 @default.
• W2014570087 hasConceptScore W2014570087C502942594 @default.
• W2014570087 hasConceptScore W2014570087C54355233 @default.
• W2014570087 hasConceptScore W2014570087C55493867 @default.
• W2014570087 hasConceptScore W2014570087C57074206 @default.
• W2014570087 hasConceptScore W2014570087C62112901 @default.
• W2014570087 hasConceptScore W2014570087C62478195 @default.
• W2014570087 hasConceptScore W2014570087C79879829 @default.
• W2014570087 hasConceptScore W2014570087C81885089 @default.
• W2014570087 hasConceptScore W2014570087C86803240 @default.
• W2014570087 hasConceptScore W2014570087C95444343 @default.
• W2014570087 hasConceptScore W2014570087C97029542 @default.
• W2014570087 hasIssue "3" @default.
• W2014570087 hasLocation W20145700871 @default.
• W2014570087 hasOpenAccess W2014570087 @default.
• W2014570087 hasPrimaryLocation W20145700871 @default.
• W2014570087 hasRelatedWork W2004726042 @default.
• W2014570087 hasRelatedWork W2143316408 @default.
• W2014570087 hasRelatedWork W2219045298 @default.
• W2014570087 hasRelatedWork W2376940852 @default.
• W2014570087 hasRelatedWork W2381340599 @default.
• W2014570087 hasRelatedWork W2384817912 @default.
• W2014570087 hasRelatedWork W2388803918 @default.
• W2014570087 hasRelatedWork W2594973917 @default.
• W2014570087 hasRelatedWork W3035328115 @default.

• next