FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014570674> ?p ?o ?g. }

• W2014570674 endingPage "500" @default.
• W2014570674 startingPage "491" @default.
• W2014570674 abstract "This study was conducted to evaluate the effects of fibroblast growth factor 1 (FGF-1), fibroblast growth factor 2 (FGF-2), or luteinizing hormone (LH) on proliferation and progesterone secretion of ovine luteal cells from days 5, 10, or 15 after estrus (estrus = day 0; n = 4 or 5 ewes/day). After enzymatic dispersion, luteal cells were incubated in the presence or absence of various doses of FGF-1, FGF-2, LH, or fetal bovine serum (FBS) (positive control) in serum-free media for 7 days in 24-well plates. Cells were counted on day 7 of culture and media analyzed for progesterone concentration. For all treatments, maximal effects (Emax) and dissociation constants (KD) were calculated. In addition, luteal cells were cultured in eight-chamber slides and treated as above, but on day 7 of culture cells were fixed and stained for the presence of 3beta-hydroxy-delta 5-steroid dehydrogenase (3beta HSD). The number of steroidogenic (3beta HSD positive) cells per unit area was counted for control cultures (no treatment) and cultures treated with the most effective doses of FGF-1, FGF-2, LH, OR FBS in proliferation and (or) progesterone assays. FGF-1, FGF-2, AND FBS stimulated (p < 0.05) proliferation of luteal cells from all stages of luteal development in a dose-dependent manner. In addition, LH increased (p < 0.01) the number of 3beta HSD-positive cells across all stages of luteal development. Moreover, LH and FBS increased (p < 0.05) progesterone secretion by luteal cells from all stages in a dose-responsive manner, but the effects of FGF-1 and FGF-2 were variable. For proliferation, the Emax of all factors was greatest (p < 0.01) on day 5, whereas the KD values were similar across days of the estrous cycle. For progesterone production, the Emax and KD of LH and FBS were similar and did not differ across the estrous cycle. These data demonstrate the luteal cells from the early luteal phase of the estrous cycle exhibit the greatest ability to proliferate and (or) increase their progesterone secretion in response to FGF-1, FGF-2, LH, or FBS. In addition, although LH does not affect the total number of luteal cells in culture, it does increase the number of steroidogenic cells. These data indicate that in addition to LH, fibroblast growth factors may be involved in regulation of luteal growth and differentiation in ewes." @default.
• W2014570674 created "2016-06-24" @default.
• W2014570674 creator A5007696844 @default.
• W2014570674 creator A5015749120 @default.
• W2014570674 creator A5053162920 @default.
• W2014570674 creator A5082339347 @default.
• W2014570674 creator A5086876404 @default.
• W2014570674 date "1995-04-01" @default.
• W2014570674 modified "2023-09-25" @default.
• W2014570674 title "Proliferation and progesterone production of ovine luteal cells from several stages of the estrous cycle: effects of fibroblast growth factors and luteinizing hormone" @default.
• W2014570674 cites W103446480 @default.
• W2014570674 cites W1897866650 @default.
• W2014570674 cites W1970491784 @default.
• W2014570674 cites W1976401061 @default.
• W2014570674 cites W1977881408 @default.
• W2014570674 cites W1978153788 @default.
• W2014570674 cites W1978623509 @default.
• W2014570674 cites W1979403186 @default.
• W2014570674 cites W1984391895 @default.
• W2014570674 cites W2001211238 @default.
• W2014570674 cites W2008830821 @default.
• W2014570674 cites W2011563942 @default.
• W2014570674 cites W2014928377 @default.
• W2014570674 cites W2020387392 @default.
• W2014570674 cites W2022109629 @default.
• W2014570674 cites W2022223644 @default.
• W2014570674 cites W2024787221 @default.
• W2014570674 cites W2031364391 @default.
• W2014570674 cites W2035691099 @default.
• W2014570674 cites W2060528857 @default.
• W2014570674 cites W2066665279 @default.
• W2014570674 cites W2066769255 @default.
• W2014570674 cites W2070168511 @default.
• W2014570674 cites W2085128854 @default.
• W2014570674 cites W2087762971 @default.
• W2014570674 cites W2087834198 @default.
• W2014570674 cites W2088314320 @default.
• W2014570674 cites W2090890316 @default.
• W2014570674 cites W2099543104 @default.
• W2014570674 cites W2118216398 @default.
• W2014570674 cites W2131807383 @default.
• W2014570674 cites W2133685524 @default.
• W2014570674 cites W2156495778 @default.
• W2014570674 cites W2158174730 @default.
• W2014570674 cites W2159368571 @default.
• W2014570674 cites W2165137831 @default.
• W2014570674 cites W2169173740 @default.
• W2014570674 cites W2313913288 @default.
• W2014570674 cites W2404362464 @default.
• W2014570674 cites W2424977977 @default.
• W2014570674 cites W245747599 @default.
• W2014570674 cites W2465195774 @default.
• W2014570674 doi "https://doi.org/10.1139/y95-062" @default.
• W2014570674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7545534" @default.
• W2014570674 hasPublicationYear "1995" @default.
• W2014570674 type Work @default.
• W2014570674 sameAs 2014570674 @default.
• W2014570674 citedByCount "45" @default.
• W2014570674 countsByYear W20145706742013 @default.
• W2014570674 countsByYear W20145706742014 @default.
• W2014570674 countsByYear W20145706742017 @default.
• W2014570674 countsByYear W20145706742018 @default.
• W2014570674 countsByYear W20145706742019 @default.
• W2014570674 countsByYear W20145706742021 @default.
• W2014570674 countsByYear W20145706742023 @default.
• W2014570674 crossrefType "journal-article" @default.
• W2014570674 hasAuthorship W2014570674A5007696844 @default.
• W2014570674 hasAuthorship W2014570674A5015749120 @default.
• W2014570674 hasAuthorship W2014570674A5053162920 @default.
• W2014570674 hasAuthorship W2014570674A5082339347 @default.
• W2014570674 hasAuthorship W2014570674A5086876404 @default.
• W2014570674 hasConcept C126322002 @default.
• W2014570674 hasConcept C134018914 @default.
• W2014570674 hasConcept C143228043 @default.
• W2014570674 hasConcept C170493617 @default.
• W2014570674 hasConcept C185592680 @default.
• W2014570674 hasConcept C1998276 @default.
• W2014570674 hasConcept C2778575703 @default.
• W2014570674 hasConcept C71315377 @default.
• W2014570674 hasConcept C71924100 @default.
• W2014570674 hasConcept C74373430 @default.
• W2014570674 hasConcept C86803240 @default.
• W2014570674 hasConceptScore W2014570674C126322002 @default.
• W2014570674 hasConceptScore W2014570674C134018914 @default.
• W2014570674 hasConceptScore W2014570674C143228043 @default.
• W2014570674 hasConceptScore W2014570674C170493617 @default.
• W2014570674 hasConceptScore W2014570674C185592680 @default.
• W2014570674 hasConceptScore W2014570674C1998276 @default.
• W2014570674 hasConceptScore W2014570674C2778575703 @default.
• W2014570674 hasConceptScore W2014570674C71315377 @default.
• W2014570674 hasConceptScore W2014570674C71924100 @default.
• W2014570674 hasConceptScore W2014570674C74373430 @default.
• W2014570674 hasConceptScore W2014570674C86803240 @default.
• W2014570674 hasIssue "4" @default.
• W2014570674 hasLocation W20145706741 @default.
• W2014570674 hasLocation W20145706742 @default.
• W2014570674 hasOpenAccess W2014570674 @default.
• W2014570674 hasPrimaryLocation W20145706741 @default.

• next