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• W2014572714 abstract "Insulin-dependent diabetes mellitus (IDDM) in Caucasians is closely associated with the HLA-DQ gene, especially the residue 57 of the DQβ chain. Aspartic acid at this position provides protection against IDDM, and substitution of this residue by alanine, valine or serine increases susceptibility to IDDM. To determine whether this is a common feature of IDDM in different ethnic groups, we studied DQB1 DNA in Japanese patients with IDDM by polymerase chain reaction and non-radioactive restriction site analysis. In contrast to Caucasian patients with IDDM, most Japanese patients with IDDM possessed at least one aspartic acid at position 57 of DQβ. This finding strongly suggests that aspartic acid at position 57 of DQβ does not protect the Japanese from IDDM." @default.
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• W2014572714 date "1990-04-01" @default.
• W2014572714 modified "2023-09-27" @default.
• W2014572714 title "Aspartic acid at position 57 of the HLA-DQβ chain is not protective against insulin-dependent diabetes mellitus in Japanese people" @default.
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• W2014572714 doi "https://doi.org/10.1016/0896-8411(90)90138-i" @default.
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