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- W2014574383 abstract "Abstract Introduction Very little is known about the influence of early-onset infections and perinatal complications on CD4+/CD25+ lymphocytes in prematures. Aim Assessment of the percentage and number of CD4+/CD25+ in prematures, including their sex, birth asphyxia, kind of early-onset infection and mode of delivery. Material and method The study comprised 50 prematures born between 26-37 week of gestation, among them 27 infected (sepsis – 15, pneumonia – 12) and 23 without infection. The immunological examination comprised once determination of leukocytes, lymphocytes, CD3+, CD4+ and CD25+ in peripheral vein blood using FACS scan flow cytometer and mononuclear antibodies from Becton Dickinson. Results The mean percentage and mean number of CD4+/CD25+ in infected prematures were significantly higher than in babies without infection. Male infected prematures had significantly higher values of CD4+/CD25+ than boys without infection. Any correlation between CD4+/CD25+ values and Apgar score and mode of delivery was noted. Conclusions 1. Severe early-onset infection, independently of their kind, increase the percentage and number of CD4+/CD25+ in prematures. Estimate of CD4+/CD25+ may be a marker of early-onset infection, especially in cases with negative results of bacteriological findings. 2. Birth asphyxia and nonphysiological delivery had any influence of quantitive changes of CD4+/CD25+ in prematures." @default.
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- W2014574383 date "2013-07-01" @default.
- W2014574383 modified "2023-09-23" @default.
- W2014574383 title "Limfocyty CD4+/CD25+ w obwodowej krwi żylnej noworodków urodzonych przedwcześnie" @default.
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- W2014574383 doi "https://doi.org/10.1016/j.pepo.2013.03.014" @default.
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