Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014575289> ?p ?o ?g. }
- W2014575289 endingPage "165" @default.
- W2014575289 startingPage "158" @default.
- W2014575289 abstract "Genome deciphering revealed that Mycobacterium tuberculosis encodes a single type II topoisomerase contrary to common bacteria harboring two type II topoisomerases (DNA gyrase and topoisomerase IV). Functions of the M. tuberculosis type II topoisomerase were explored after cloning and expressing the subunits encoding genes in Escherichia coli. M. tuberculosis type II topoisomerase supercoiled relaxed pBR322 with a specific activity close to that of DNA gyrases of common bacteria whereas it exhibited DNA relaxation and formation of cleavable complexes with activities significantly higher than other DNA gyrases. Intermolecular passage activity evaluated by the decatenation of kinetoplast DNA was 25-fold lower than that of the topoisomerase IV from Streptococcus pneumoniae, but was markedly higher than that of the E. coli gyrase. Overall, the type II topoisomerase of M. tuberculosis exhibits classical polyvalent activities of DNA gyrase for supercoiling but enhanced relaxation, cleavage, and decatenation activities." @default.
- W2014575289 created "2016-06-24" @default.
- W2014575289 creator A5020574513 @default.
- W2014575289 creator A5037473411 @default.
- W2014575289 creator A5055642273 @default.
- W2014575289 creator A5090449409 @default.
- W2014575289 date "2006-09-01" @default.
- W2014575289 modified "2023-10-03" @default.
- W2014575289 title "First functional characterization of a singly expressed bacterial type II topoisomerase: The enzyme from Mycobacterium tuberculosis" @default.
- W2014575289 cites W1486633844 @default.
- W2014575289 cites W1491294973 @default.
- W2014575289 cites W1546404670 @default.
- W2014575289 cites W1847467538 @default.
- W2014575289 cites W1970112406 @default.
- W2014575289 cites W2002486322 @default.
- W2014575289 cites W2008364078 @default.
- W2014575289 cites W2010590744 @default.
- W2014575289 cites W2015444876 @default.
- W2014575289 cites W2057422765 @default.
- W2014575289 cites W2065260977 @default.
- W2014575289 cites W2072413382 @default.
- W2014575289 cites W2081027015 @default.
- W2014575289 cites W2098663401 @default.
- W2014575289 cites W2099090001 @default.
- W2014575289 cites W2100467222 @default.
- W2014575289 cites W2103017729 @default.
- W2014575289 cites W2107640779 @default.
- W2014575289 cites W2112675096 @default.
- W2014575289 cites W2124376165 @default.
- W2014575289 cites W2127427236 @default.
- W2014575289 cites W2127734057 @default.
- W2014575289 cites W2132600317 @default.
- W2014575289 cites W2133548147 @default.
- W2014575289 cites W2158023121 @default.
- W2014575289 cites W2159433008 @default.
- W2014575289 cites W2164175455 @default.
- W2014575289 doi "https://doi.org/10.1016/j.bbrc.2006.07.017" @default.
- W2014575289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16876125" @default.
- W2014575289 hasPublicationYear "2006" @default.
- W2014575289 type Work @default.
- W2014575289 sameAs 2014575289 @default.
- W2014575289 citedByCount "82" @default.
- W2014575289 countsByYear W20145752892012 @default.
- W2014575289 countsByYear W20145752892013 @default.
- W2014575289 countsByYear W20145752892014 @default.
- W2014575289 countsByYear W20145752892015 @default.
- W2014575289 countsByYear W20145752892016 @default.
- W2014575289 countsByYear W20145752892017 @default.
- W2014575289 countsByYear W20145752892018 @default.
- W2014575289 countsByYear W20145752892019 @default.
- W2014575289 countsByYear W20145752892020 @default.
- W2014575289 countsByYear W20145752892021 @default.
- W2014575289 countsByYear W20145752892022 @default.
- W2014575289 countsByYear W20145752892023 @default.
- W2014575289 crossrefType "journal-article" @default.
- W2014575289 hasAuthorship W2014575289A5020574513 @default.
- W2014575289 hasAuthorship W2014575289A5037473411 @default.
- W2014575289 hasAuthorship W2014575289A5055642273 @default.
- W2014575289 hasAuthorship W2014575289A5090449409 @default.
- W2014575289 hasConcept C104317684 @default.
- W2014575289 hasConcept C142724271 @default.
- W2014575289 hasConcept C147897179 @default.
- W2014575289 hasConcept C153911025 @default.
- W2014575289 hasConcept C158456008 @default.
- W2014575289 hasConcept C167125095 @default.
- W2014575289 hasConcept C2777112418 @default.
- W2014575289 hasConcept C2777975735 @default.
- W2014575289 hasConcept C2781069245 @default.
- W2014575289 hasConcept C547475151 @default.
- W2014575289 hasConcept C552990157 @default.
- W2014575289 hasConcept C55493867 @default.
- W2014575289 hasConcept C71924100 @default.
- W2014575289 hasConcept C73573662 @default.
- W2014575289 hasConcept C86803240 @default.
- W2014575289 hasConceptScore W2014575289C104317684 @default.
- W2014575289 hasConceptScore W2014575289C142724271 @default.
- W2014575289 hasConceptScore W2014575289C147897179 @default.
- W2014575289 hasConceptScore W2014575289C153911025 @default.
- W2014575289 hasConceptScore W2014575289C158456008 @default.
- W2014575289 hasConceptScore W2014575289C167125095 @default.
- W2014575289 hasConceptScore W2014575289C2777112418 @default.
- W2014575289 hasConceptScore W2014575289C2777975735 @default.
- W2014575289 hasConceptScore W2014575289C2781069245 @default.
- W2014575289 hasConceptScore W2014575289C547475151 @default.
- W2014575289 hasConceptScore W2014575289C552990157 @default.
- W2014575289 hasConceptScore W2014575289C55493867 @default.
- W2014575289 hasConceptScore W2014575289C71924100 @default.
- W2014575289 hasConceptScore W2014575289C73573662 @default.
- W2014575289 hasConceptScore W2014575289C86803240 @default.
- W2014575289 hasIssue "1" @default.
- W2014575289 hasLocation W20145752891 @default.
- W2014575289 hasLocation W20145752892 @default.
- W2014575289 hasOpenAccess W2014575289 @default.
- W2014575289 hasPrimaryLocation W20145752891 @default.
- W2014575289 hasRelatedWork W1964037253 @default.
- W2014575289 hasRelatedWork W2035990717 @default.
- W2014575289 hasRelatedWork W2071811521 @default.
- W2014575289 hasRelatedWork W2153880231 @default.