FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014578984> ?p ?o ?g. }

• W2014578984 endingPage "353" @default.
• W2014578984 startingPage "347" @default.
• W2014578984 abstract "Lubricating gut pill (LGP), a traditional Chinese formula, was widely used for the treatment of chronic constipation, especially in the elderly, in China. However, it is unclear whether LGP-induced laxative and/or lubricating effect is involved in water and electrolytes transport in distal colonic epithelium.The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively.Application of LGP in the apical side elicited a sustained increase in short circuit current (I(SC)) response in a concentration-dependent manner. Evidence that LGP-stimulated I(SC) was due to Cl(-) secretion is based on inhibition of current by (a) a Na(+)-K(+)-2Cl(-) cotransporter inhibitor bumetanide, (b) removal of Cl(-) ions in bath solution, and (c) the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel blocker DPC, suggesting that a apical cAMP-dependent Cl(-) channel was activated. LGP-stimulated I(SC) was also strongly inhibited by pretreatment with clotrimazole, indicating that the basolateral K(+) channel was also involved in maintaining this cAMP-dependent Cl(-) secretion. Pretreatment of tissues with indomethacin, but not atropine, tetrodotoxin or hexamethonium, inhibited LGP-induced response. In a rat constipation model, oral administration with LGP was significantly restored number of fecal pellets, water content and mucus secretion compared with loperamide-treated group alone.LGP enhances Cl(-) secretion that is mostly mediated through the release of cyclooxygenase metabolites, by which provided an osmotic force for the subsequent laxative action observed in the rat constipation model." @default.
• W2014578984 created "2016-06-24" @default.
• W2014578984 creator A5008976005 @default.
• W2014578984 creator A5013743683 @default.
• W2014578984 creator A5016260712 @default.
• W2014578984 creator A5016577538 @default.
• W2014578984 creator A5059628008 @default.
• W2014578984 creator A5066432015 @default.
• W2014578984 creator A5069365973 @default.
• W2014578984 date "2010-07-01" @default.
• W2014578984 modified "2023-10-16" @default.
• W2014578984 title "Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl− secretion across distal colonic epithelium" @default.
• W2014578984 cites W1526961607 @default.
• W2014578984 cites W1966947122 @default.
• W2014578984 cites W1969197754 @default.
• W2014578984 cites W1972139530 @default.
• W2014578984 cites W1972279565 @default.
• W2014578984 cites W1996786858 @default.
• W2014578984 cites W1998886844 @default.
• W2014578984 cites W2019249854 @default.
• W2014578984 cites W2026098937 @default.
• W2014578984 cites W2042818226 @default.
• W2014578984 cites W2072922834 @default.
• W2014578984 cites W2086675535 @default.
• W2014578984 cites W2092290049 @default.
• W2014578984 cites W2096418813 @default.
• W2014578984 cites W2097821931 @default.
• W2014578984 cites W2106835468 @default.
• W2014578984 cites W2114250125 @default.
• W2014578984 cites W2143568628 @default.
• W2014578984 cites W2144603992 @default.
• W2014578984 cites W2149135442 @default.
• W2014578984 cites W2162912541 @default.
• W2014578984 cites W2201317514 @default.
• W2014578984 cites W4232332245 @default.
• W2014578984 cites W75605543 @default.
• W2014578984 doi "https://doi.org/10.1016/j.jep.2010.05.018" @default.
• W2014578984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20488235" @default.
• W2014578984 hasPublicationYear "2010" @default.
• W2014578984 type Work @default.
• W2014578984 sameAs 2014578984 @default.
• W2014578984 citedByCount "12" @default.
• W2014578984 countsByYear W20145789842014 @default.
• W2014578984 countsByYear W20145789842015 @default.
• W2014578984 countsByYear W20145789842016 @default.
• W2014578984 countsByYear W20145789842017 @default.
• W2014578984 countsByYear W20145789842018 @default.
• W2014578984 countsByYear W20145789842020 @default.
• W2014578984 countsByYear W20145789842022 @default.
• W2014578984 countsByYear W20145789842023 @default.
• W2014578984 crossrefType "journal-article" @default.
• W2014578984 hasAuthorship W2014578984A5008976005 @default.
• W2014578984 hasAuthorship W2014578984A5013743683 @default.
• W2014578984 hasAuthorship W2014578984A5016260712 @default.
• W2014578984 hasAuthorship W2014578984A5016577538 @default.
• W2014578984 hasAuthorship W2014578984A5059628008 @default.
• W2014578984 hasAuthorship W2014578984A5066432015 @default.
• W2014578984 hasAuthorship W2014578984A5069365973 @default.
• W2014578984 hasConcept C126322002 @default.
• W2014578984 hasConcept C134018914 @default.
• W2014578984 hasConcept C178790620 @default.
• W2014578984 hasConcept C185592680 @default.
• W2014578984 hasConcept C188053792 @default.
• W2014578984 hasConcept C2775859210 @default.
• W2014578984 hasConcept C2775893369 @default.
• W2014578984 hasConcept C2776741303 @default.
• W2014578984 hasConcept C2776919887 @default.
• W2014578984 hasConcept C2776938444 @default.
• W2014578984 hasConcept C2777573665 @default.
• W2014578984 hasConcept C2778212192 @default.
• W2014578984 hasConcept C2778428886 @default.
• W2014578984 hasConcept C2779802037 @default.
• W2014578984 hasConcept C2780661987 @default.
• W2014578984 hasConcept C2781112942 @default.
• W2014578984 hasConcept C537181965 @default.
• W2014578984 hasConcept C71924100 @default.
• W2014578984 hasConcept C83743174 @default.
• W2014578984 hasConcept C98274493 @default.
• W2014578984 hasConceptScore W2014578984C126322002 @default.
• W2014578984 hasConceptScore W2014578984C134018914 @default.
• W2014578984 hasConceptScore W2014578984C178790620 @default.
• W2014578984 hasConceptScore W2014578984C185592680 @default.
• W2014578984 hasConceptScore W2014578984C188053792 @default.
• W2014578984 hasConceptScore W2014578984C2775859210 @default.
• W2014578984 hasConceptScore W2014578984C2775893369 @default.
• W2014578984 hasConceptScore W2014578984C2776741303 @default.
• W2014578984 hasConceptScore W2014578984C2776919887 @default.
• W2014578984 hasConceptScore W2014578984C2776938444 @default.
• W2014578984 hasConceptScore W2014578984C2777573665 @default.
• W2014578984 hasConceptScore W2014578984C2778212192 @default.
• W2014578984 hasConceptScore W2014578984C2778428886 @default.
• W2014578984 hasConceptScore W2014578984C2779802037 @default.
• W2014578984 hasConceptScore W2014578984C2780661987 @default.
• W2014578984 hasConceptScore W2014578984C2781112942 @default.
• W2014578984 hasConceptScore W2014578984C537181965 @default.
• W2014578984 hasConceptScore W2014578984C71924100 @default.
• W2014578984 hasConceptScore W2014578984C83743174 @default.
• W2014578984 hasConceptScore W2014578984C98274493 @default.

• next