FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014583580> ?p ?o ?g. }

• W2014583580 endingPage "258" @default.
• W2014583580 startingPage "243" @default.
• W2014583580 abstract "Antisense oligonucleotides are efficient tools for the inhibition of gene expression in a sequence specific way. Natural oligonucleotides are decomposed rapidly in biological systems, which strongly restrict their application. In contrast, artificial oligonucleotides are designed to be more stable against degradation than the target mRNA, which results in a catalytic effect of the drug. Modification of the phosphate linkage has been the first successful strategy for antisense drug developments and Fomivirsene the first antisense drug in therapy. The launch of Fomivirsene has resulted in a revolutionary spin off to antisense research leading to a second generation of antisense oligonucleotides, which are stable against oligonucleotide cleaving enzymes. Among these, oligonucleotides bearing an alkoxy substituent in position 2' were the most successful ones. The third generation of antisense oligonucleotides contains structure elements, which enhance the antisense action. Zwitterionic oligonucleotides show remarkable results, first, because the stability against ribozymes is largely increased, and secondly, because the electrostatic repulsion between the anionic sense and the zwitterionic antisense cords is minimized. Promising new target molecules in antisense research are oligonucleotide chimäres, which enhance the antisense action (chimäres with intercalators, chelators or polyamines) or enable an application as sequence specific detectors (chimäres with biotin, fluorescein or radioligands)." @default.
• W2014583580 created "2016-06-24" @default.
• W2014583580 creator A5002164427 @default.
• W2014583580 creator A5006866855 @default.
• W2014583580 date "2003-03-01" @default.
• W2014583580 modified "2023-10-09" @default.
• W2014583580 title "Structural modifications of antisense oligonucleotides" @default.
• W2014583580 cites W1967973226 @default.
• W2014583580 cites W1985144500 @default.
• W2014583580 cites W1997096397 @default.
• W2014583580 cites W2002992605 @default.
• W2014583580 cites W2015675573 @default.
• W2014583580 cites W2016170201 @default.
• W2014583580 cites W2019818589 @default.
• W2014583580 cites W2023018983 @default.
• W2014583580 cites W2031092694 @default.
• W2014583580 cites W2035236277 @default.
• W2014583580 cites W2036601571 @default.
• W2014583580 cites W2044443446 @default.
• W2014583580 cites W2060985368 @default.
• W2014583580 cites W2064334853 @default.
• W2014583580 cites W2082423969 @default.
• W2014583580 cites W2084880857 @default.
• W2014583580 cites W2086010638 @default.
• W2014583580 cites W2092347182 @default.
• W2014583580 cites W2113211717 @default.
• W2014583580 cites W2118608498 @default.
• W2014583580 cites W2130773536 @default.
• W2014583580 cites W2140648390 @default.
• W2014583580 cites W2150303730 @default.
• W2014583580 cites W2152492092 @default.
• W2014583580 cites W2159380570 @default.
• W2014583580 cites W2169369832 @default.
• W2014583580 cites W2172105451 @default.
• W2014583580 cites W2334031206 @default.
• W2014583580 cites W2999839250 @default.
• W2014583580 doi "https://doi.org/10.1016/s0014-827x(03)00022-3" @default.
• W2014583580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12620420" @default.
• W2014583580 hasPublicationYear "2003" @default.
• W2014583580 type Work @default.
• W2014583580 sameAs 2014583580 @default.
• W2014583580 citedByCount "79" @default.
• W2014583580 countsByYear W20145835802012 @default.
• W2014583580 countsByYear W20145835802013 @default.
• W2014583580 countsByYear W20145835802014 @default.
• W2014583580 countsByYear W20145835802015 @default.
• W2014583580 countsByYear W20145835802016 @default.
• W2014583580 countsByYear W20145835802017 @default.
• W2014583580 countsByYear W20145835802018 @default.
• W2014583580 countsByYear W20145835802019 @default.
• W2014583580 countsByYear W20145835802020 @default.
• W2014583580 countsByYear W20145835802021 @default.
• W2014583580 countsByYear W20145835802022 @default.
• W2014583580 countsByYear W20145835802023 @default.
• W2014583580 crossrefType "journal-article" @default.
• W2014583580 hasAuthorship W2014583580A5002164427 @default.
• W2014583580 hasAuthorship W2014583580A5006866855 @default.
• W2014583580 hasConcept C104317684 @default.
• W2014583580 hasConcept C129312508 @default.
• W2014583580 hasConcept C143141573 @default.
• W2014583580 hasConcept C14363569 @default.
• W2014583580 hasConcept C147789679 @default.
• W2014583580 hasConcept C153911025 @default.
• W2014583580 hasConcept C185592680 @default.
• W2014583580 hasConcept C202416437 @default.
• W2014583580 hasConcept C2908938912 @default.
• W2014583580 hasConcept C552990157 @default.
• W2014583580 hasConcept C55493867 @default.
• W2014583580 hasConcept C67705224 @default.
• W2014583580 hasConcept C76346623 @default.
• W2014583580 hasConcept C86803240 @default.
• W2014583580 hasConceptScore W2014583580C104317684 @default.
• W2014583580 hasConceptScore W2014583580C129312508 @default.
• W2014583580 hasConceptScore W2014583580C143141573 @default.
• W2014583580 hasConceptScore W2014583580C14363569 @default.
• W2014583580 hasConceptScore W2014583580C147789679 @default.
• W2014583580 hasConceptScore W2014583580C153911025 @default.
• W2014583580 hasConceptScore W2014583580C185592680 @default.
• W2014583580 hasConceptScore W2014583580C202416437 @default.
• W2014583580 hasConceptScore W2014583580C2908938912 @default.
• W2014583580 hasConceptScore W2014583580C552990157 @default.
• W2014583580 hasConceptScore W2014583580C55493867 @default.
• W2014583580 hasConceptScore W2014583580C67705224 @default.
• W2014583580 hasConceptScore W2014583580C76346623 @default.
• W2014583580 hasConceptScore W2014583580C86803240 @default.
• W2014583580 hasIssue "3" @default.
• W2014583580 hasLocation W20145835801 @default.
• W2014583580 hasLocation W20145835802 @default.
• W2014583580 hasOpenAccess W2014583580 @default.
• W2014583580 hasPrimaryLocation W20145835801 @default.
• W2014583580 hasRelatedWork W1562741416 @default.
• W2014583580 hasRelatedWork W1963685068 @default.
• W2014583580 hasRelatedWork W1970259879 @default.
• W2014583580 hasRelatedWork W1989397495 @default.
• W2014583580 hasRelatedWork W2391266892 @default.
• W2014583580 hasRelatedWork W2473745500 @default.
• W2014583580 hasRelatedWork W2506564080 @default.
• W2014583580 hasRelatedWork W4200076778 @default.

• next