Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014585251> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2014585251 endingPage "9421" @default.
- W2014585251 startingPage "9417" @default.
- W2014585251 abstract "The murine alpha 1-protease inhibitors (alpha 1-PI) are encoded by a small gene family on chromosome 12. Studies of alpha 1-PI and other serine protease inhibitor genes have revealed an unusually high rate of mutation of the reactive centers of the inhibitors. Using a modification of the PCR technique, we have previously identified five distinct alpha 1 PI reactive site sequences present in the genome of C57BL/6 mice. In this report, we use cDNA cloning techniques to demonstrate that all five genes are expressed in the adult mouse liver. DNA sequence analysis shows that three of the five mRNAs expressed have a substitution for methionine-353, which is essential for normal activity of the homologous human protein, alpha 1-antitrypsin (alpha 1-AT). Comparison of the DNA sequences of the five cDNAs indicates a higher degree of polymorphism in the carboxyl-terminal half of the protein and an extraordinarily replacement/silent ratio of nucleotide changes in a narrow region surrounding the reactive site. The clustering of polymorphisms near the reactive site combined with the high replacement/silent ratio suggest an evolutionary mechanism that apparently selects for functional diversity of the alpha 1-PI genes. Finally, modeling of the three-dimensional positions of the alpha 1-PI polymorphic residues into the homologous positions of the crystallographic structure of ovalbumin, a member of the alpha 1-PI supergene family, predicts that many of these amino acids are on the surfaces, which are likely to interact with the protease targets." @default.
- W2014585251 created "2016-06-24" @default.
- W2014585251 creator A5025291184 @default.
- W2014585251 creator A5053500125 @default.
- W2014585251 date "1991-11-01" @default.
- W2014585251 modified "2023-09-23" @default.
- W2014585251 title "Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence." @default.
- W2014585251 cites W1243723833 @default.
- W2014585251 cites W1504512890 @default.
- W2014585251 cites W1583012584 @default.
- W2014585251 cites W1646314937 @default.
- W2014585251 cites W1783764945 @default.
- W2014585251 cites W1887358571 @default.
- W2014585251 cites W1968882642 @default.
- W2014585251 cites W1978532589 @default.
- W2014585251 cites W2001570522 @default.
- W2014585251 cites W2009310436 @default.
- W2014585251 cites W2011479978 @default.
- W2014585251 cites W2033134260 @default.
- W2014585251 cites W2033697361 @default.
- W2014585251 cites W2040295790 @default.
- W2014585251 cites W2041065606 @default.
- W2014585251 cites W2051329975 @default.
- W2014585251 cites W2066958900 @default.
- W2014585251 cites W2079662773 @default.
- W2014585251 cites W2083747207 @default.
- W2014585251 cites W2102129370 @default.
- W2014585251 cites W2107873069 @default.
- W2014585251 cites W2132798962 @default.
- W2014585251 cites W2150837401 @default.
- W2014585251 cites W2235698808 @default.
- W2014585251 cites W330357786 @default.
- W2014585251 doi "https://doi.org/10.1073/pnas.88.21.9417" @default.
- W2014585251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52728" @default.
- W2014585251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1946354" @default.
- W2014585251 hasPublicationYear "1991" @default.
- W2014585251 type Work @default.
- W2014585251 sameAs 2014585251 @default.
- W2014585251 citedByCount "61" @default.
- W2014585251 countsByYear W20145852512013 @default.
- W2014585251 countsByYear W20145852512014 @default.
- W2014585251 countsByYear W20145852512016 @default.
- W2014585251 countsByYear W20145852512017 @default.
- W2014585251 countsByYear W20145852512022 @default.
- W2014585251 crossrefType "journal-article" @default.
- W2014585251 hasAuthorship W2014585251A5025291184 @default.
- W2014585251 hasAuthorship W2014585251A5053500125 @default.
- W2014585251 hasBestOaLocation W20145852511 @default.
- W2014585251 hasConcept C104317684 @default.
- W2014585251 hasConcept C153911025 @default.
- W2014585251 hasConcept C167625842 @default.
- W2014585251 hasConcept C187882448 @default.
- W2014585251 hasConcept C54355233 @default.
- W2014585251 hasConcept C86803240 @default.
- W2014585251 hasConceptScore W2014585251C104317684 @default.
- W2014585251 hasConceptScore W2014585251C153911025 @default.
- W2014585251 hasConceptScore W2014585251C167625842 @default.
- W2014585251 hasConceptScore W2014585251C187882448 @default.
- W2014585251 hasConceptScore W2014585251C54355233 @default.
- W2014585251 hasConceptScore W2014585251C86803240 @default.
- W2014585251 hasIssue "21" @default.
- W2014585251 hasLocation W20145852511 @default.
- W2014585251 hasLocation W20145852512 @default.
- W2014585251 hasLocation W20145852513 @default.
- W2014585251 hasLocation W20145852514 @default.
- W2014585251 hasOpenAccess W2014585251 @default.
- W2014585251 hasPrimaryLocation W20145852511 @default.
- W2014585251 hasRelatedWork W1786536704 @default.
- W2014585251 hasRelatedWork W1981233799 @default.
- W2014585251 hasRelatedWork W1984646339 @default.
- W2014585251 hasRelatedWork W1989391836 @default.
- W2014585251 hasRelatedWork W1999890227 @default.
- W2014585251 hasRelatedWork W2015157953 @default.
- W2014585251 hasRelatedWork W2052370395 @default.
- W2014585251 hasRelatedWork W2063806338 @default.
- W2014585251 hasRelatedWork W2072071126 @default.
- W2014585251 hasRelatedWork W4250058125 @default.
- W2014585251 hasVolume "88" @default.
- W2014585251 isParatext "false" @default.
- W2014585251 isRetracted "false" @default.
- W2014585251 magId "2014585251" @default.
- W2014585251 workType "article" @default.