FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014585689> ?p ?o ?g. }

• W2014585689 endingPage "98" @default.
• W2014585689 startingPage "92" @default.
• W2014585689 abstract "Since the discovery of RNAi technology, several functional genomic and disease therapy studies have been conducted using this technique in the field of oncology and virology. RNAi-based antiviral therapies are being studied for the treatment of retroviruses such as HIV-1. These studies include the silencing of regulatory, infectivity and structural genes. The HTLV-1 structural genes are responsible for the synthesis of proteins involved in the entry, assembly and release of particles during viral infection. To examine the possibility of silencing HTLV-1 genes gag and env by RNA interference technology, these genes were cloned into reporter plasmids. These vectors expressed the target mRNAs fused to EGFP reporter genes. Three small interference RNAs (siRNAs) corresponding to gag and three corresponding to env were designed to analyze the effect of silencing by RNAi technology. The plasmids and siRNAs were co-transfected into HEK 293 cells. The results demonstrated that the expression of the HTLV-1 gag and env genes decreased significantly in vitro. Thus, siRNAs can be used to inhibit HTLV-1 structural genes in transformed cells, which could provide a tool for clarifying the roles of HTLV-1 structural genes, as well as a therapy for this infection." @default.
• W2014585689 created "2016-06-24" @default.
• W2014585689 creator A5010187682 @default.
• W2014585689 creator A5017122218 @default.
• W2014585689 creator A5021887908 @default.
• W2014585689 creator A5032785820 @default.
• W2014585689 creator A5035206619 @default.
• W2014585689 creator A5046127229 @default.
• W2014585689 creator A5055597990 @default.
• W2014585689 creator A5064146570 @default.
• W2014585689 date "2011-04-01" @default.
• W2014585689 modified "2023-10-10" @default.
• W2014585689 title "Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells" @default.
• W2014585689 cites W1488192195 @default.
• W2014585689 cites W1611419331 @default.
• W2014585689 cites W1647075334 @default.
• W2014585689 cites W1843667952 @default.
• W2014585689 cites W1963640296 @default.
• W2014585689 cites W1968893198 @default.
• W2014585689 cites W1969899671 @default.
• W2014585689 cites W1974424390 @default.
• W2014585689 cites W1981906666 @default.
• W2014585689 cites W1984006325 @default.
• W2014585689 cites W1993961716 @default.
• W2014585689 cites W2007251666 @default.
• W2014585689 cites W2008559030 @default.
• W2014585689 cites W2012188597 @default.
• W2014585689 cites W2013436183 @default.
• W2014585689 cites W2015456365 @default.
• W2014585689 cites W2019431237 @default.
• W2014585689 cites W2021545782 @default.
• W2014585689 cites W2029433700 @default.
• W2014585689 cites W2037141750 @default.
• W2014585689 cites W2040563602 @default.
• W2014585689 cites W2045651327 @default.
• W2014585689 cites W2047411718 @default.
• W2014585689 cites W2051252016 @default.
• W2014585689 cites W2060796790 @default.
• W2014585689 cites W2072958095 @default.
• W2014585689 cites W2073858684 @default.
• W2014585689 cites W2081080474 @default.
• W2014585689 cites W2081100261 @default.
• W2014585689 cites W2084851425 @default.
• W2014585689 cites W2089697675 @default.
• W2014585689 cites W2112395285 @default.
• W2014585689 cites W2127493394 @default.
• W2014585689 cites W2133903293 @default.
• W2014585689 cites W2136327338 @default.
• W2014585689 cites W2136447541 @default.
• W2014585689 cites W2137578684 @default.
• W2014585689 cites W2138230142 @default.
• W2014585689 cites W2140440263 @default.
• W2014585689 cites W2142506979 @default.
• W2014585689 cites W2155412395 @default.
• W2014585689 cites W2157155233 @default.
• W2014585689 cites W2158110042 @default.
• W2014585689 cites W2159955926 @default.
• W2014585689 cites W2185387788 @default.
• W2014585689 cites W4254038279 @default.
• W2014585689 cites W2168081547 @default.
• W2014585689 doi "https://doi.org/10.1016/j.jviromet.2011.01.012" @default.
• W2014585689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7112899" @default.
• W2014585689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21277903" @default.
• W2014585689 hasPublicationYear "2011" @default.
• W2014585689 type Work @default.
• W2014585689 sameAs 2014585689 @default.
• W2014585689 citedByCount "4" @default.
• W2014585689 countsByYear W20145856892014 @default.
• W2014585689 countsByYear W20145856892017 @default.
• W2014585689 crossrefType "journal-article" @default.
• W2014585689 hasAuthorship W2014585689A5010187682 @default.
• W2014585689 hasAuthorship W2014585689A5017122218 @default.
• W2014585689 hasAuthorship W2014585689A5021887908 @default.
• W2014585689 hasAuthorship W2014585689A5032785820 @default.
• W2014585689 hasAuthorship W2014585689A5035206619 @default.
• W2014585689 hasAuthorship W2014585689A5046127229 @default.
• W2014585689 hasAuthorship W2014585689A5055597990 @default.
• W2014585689 hasAuthorship W2014585689A5064146570 @default.
• W2014585689 hasBestOaLocation W20145856891 @default.
• W2014585689 hasConcept C104317684 @default.
• W2014585689 hasConcept C119056186 @default.
• W2014585689 hasConcept C150194340 @default.
• W2014585689 hasConcept C153911025 @default.
• W2014585689 hasConcept C159047783 @default.
• W2014585689 hasConcept C161733203 @default.
• W2014585689 hasConcept C166703698 @default.
• W2014585689 hasConcept C174510640 @default.
• W2014585689 hasConcept C2191507 @default.
• W2014585689 hasConcept C22615655 @default.
• W2014585689 hasConcept C22744801 @default.
• W2014585689 hasConcept C54009773 @default.
• W2014585689 hasConcept C54355233 @default.
• W2014585689 hasConcept C60723119 @default.
• W2014585689 hasConcept C67705224 @default.
• W2014585689 hasConcept C86803240 @default.
• W2014585689 hasConceptScore W2014585689C104317684 @default.
• W2014585689 hasConceptScore W2014585689C119056186 @default.
• W2014585689 hasConceptScore W2014585689C150194340 @default.

• next