FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014588596> ?p ?o ?g. }

• W2014588596 endingPage "e18575" @default.
• W2014588596 startingPage "e18575" @default.
• W2014588596 abstract "Mesangial matrix expansion is a prominent feature of the most common form of glomerulonephritis, IgA nephropathy (IgAN). To find molecular markers and improve the understanding of the disease, the gene and protein expression of proteoglycans were investigated in biopsies from IgAN patients and correlated to clinical and morphological data. We collected and microdissected renal biopsies from IgAN patients (n = 19) and from healthy kidney donors (n = 14). Patients were followed for an average time of 4 years and blood pressure was according to target guidelines. Distinct patterns of gene expression were seen in glomerular and tubulo-interstitial cells. Three of the proteoglycans investigated were found to be of special interest and upregulated in glomeruli: perlecan, decorin and biglycan. Perlecan gene expression negatively correlated to albumin excretion and progress of the disease. Abundant decorin protein expression was found in sclerotic glomeruli, but not in unaffected glomeruli from IgAN patients or in controls. Transforming growth factor beta (TGF-β), known to interact with perlecan, decorin and biglycan, were upregulated both on gene and protein level in the glomeruli. This study provides further insight into the molecular mechanisms involved in mesangial matrix expansion in IgAN. We conclude that perlecan is a possible prognostic marker for patients with IgAN. In addition, the up-regulation of biglycan and decorin, as well as TGF-β itself, indicate that regulation of TGF-β, and other profibrotic markers plays a role in IgAN pathology." @default.
• W2014588596 created "2016-06-24" @default.
• W2014588596 creator A5022809040 @default.
• W2014588596 creator A5034978139 @default.
• W2014588596 creator A5042130334 @default.
• W2014588596 creator A5048193083 @default.
• W2014588596 creator A5068161064 @default.
• W2014588596 creator A5079475105 @default.
• W2014588596 date "2011-04-06" @default.
• W2014588596 modified "2023-10-18" @default.
• W2014588596 title "Role of Glomerular Proteoglycans in IgA Nephropathy" @default.
• W2014588596 cites W1544527238 @default.
• W2014588596 cites W1887837461 @default.
• W2014588596 cites W1915870046 @default.
• W2014588596 cites W1970245928 @default.
• W2014588596 cites W1971086200 @default.
• W2014588596 cites W1971878230 @default.
• W2014588596 cites W1977576899 @default.
• W2014588596 cites W1980741458 @default.
• W2014588596 cites W1989255606 @default.
• W2014588596 cites W1993080627 @default.
• W2014588596 cites W2001244523 @default.
• W2014588596 cites W2010501457 @default.
• W2014588596 cites W2015724236 @default.
• W2014588596 cites W2017096535 @default.
• W2014588596 cites W2023713176 @default.
• W2014588596 cites W2025733563 @default.
• W2014588596 cites W2026840311 @default.
• W2014588596 cites W2031224882 @default.
• W2014588596 cites W2045170901 @default.
• W2014588596 cites W2047250419 @default.
• W2014588596 cites W2048254999 @default.
• W2014588596 cites W2048927510 @default.
• W2014588596 cites W2049222412 @default.
• W2014588596 cites W2054703329 @default.
• W2014588596 cites W2058478132 @default.
• W2014588596 cites W2072538390 @default.
• W2014588596 cites W2073742622 @default.
• W2014588596 cites W2075657769 @default.
• W2014588596 cites W2078809155 @default.
• W2014588596 cites W2081155030 @default.
• W2014588596 cites W2090668636 @default.
• W2014588596 cites W2097029466 @default.
• W2014588596 cites W2112549609 @default.
• W2014588596 cites W2116613369 @default.
• W2014588596 cites W2118728606 @default.
• W2014588596 cites W2119802842 @default.
• W2014588596 cites W2127463343 @default.
• W2014588596 cites W2128545033 @default.
• W2014588596 cites W2129416468 @default.
• W2014588596 cites W2145199044 @default.
• W2014588596 cites W2146559746 @default.
• W2014588596 cites W2152853007 @default.
• W2014588596 cites W2155309037 @default.
• W2014588596 cites W2159988004 @default.
• W2014588596 cites W2160588155 @default.
• W2014588596 cites W2168171496 @default.
• W2014588596 cites W2325756515 @default.
• W2014588596 cites W2332036572 @default.
• W2014588596 cites W4241655994 @default.
• W2014588596 doi "https://doi.org/10.1371/journal.pone.0018575" @default.
• W2014588596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3071844" @default.
• W2014588596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21494642" @default.
• W2014588596 hasPublicationYear "2011" @default.
• W2014588596 type Work @default.
• W2014588596 sameAs 2014588596 @default.
• W2014588596 citedByCount "36" @default.
• W2014588596 countsByYear W20145885962012 @default.
• W2014588596 countsByYear W20145885962013 @default.
• W2014588596 countsByYear W20145885962014 @default.
• W2014588596 countsByYear W20145885962015 @default.
• W2014588596 countsByYear W20145885962016 @default.
• W2014588596 countsByYear W20145885962017 @default.
• W2014588596 countsByYear W20145885962018 @default.
• W2014588596 countsByYear W20145885962019 @default.
• W2014588596 countsByYear W20145885962020 @default.
• W2014588596 countsByYear W20145885962021 @default.
• W2014588596 countsByYear W20145885962022 @default.
• W2014588596 countsByYear W20145885962023 @default.
• W2014588596 crossrefType "journal-article" @default.
• W2014588596 hasAuthorship W2014588596A5022809040 @default.
• W2014588596 hasAuthorship W2014588596A5034978139 @default.
• W2014588596 hasAuthorship W2014588596A5042130334 @default.
• W2014588596 hasAuthorship W2014588596A5048193083 @default.
• W2014588596 hasAuthorship W2014588596A5068161064 @default.
• W2014588596 hasAuthorship W2014588596A5079475105 @default.
• W2014588596 hasBestOaLocation W20145885961 @default.
• W2014588596 hasConcept C126322002 @default.
• W2014588596 hasConcept C134018914 @default.
• W2014588596 hasConcept C142724271 @default.
• W2014588596 hasConcept C189165786 @default.
• W2014588596 hasConcept C203014093 @default.
• W2014588596 hasConcept C22731427 @default.
• W2014588596 hasConcept C2776115139 @default.
• W2014588596 hasConcept C2777146197 @default.
• W2014588596 hasConcept C2778916964 @default.
• W2014588596 hasConcept C2779335624 @default.
• W2014588596 hasConcept C2779561371 @default.

• next