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• W2014589422 abstract "DNA repair gene alterations may cause a reduction in DNA repair capacity and influence an individual's susceptibility to carcinogenesis. We hypothesized that single nucleotide polymorphisms of DNA repair genes may be a risk factor for prostate cancer (PCa) susceptibility, influencing expression of homologous recombination (XRCC3) and nonhomologous end-joining (XRCC7) genes and conferring predisposition to PCa. In a case–control study, genotyping was done in 192 patients with PCa and 224 age matched unrelated healthy controls of similar ethnicity to determine variants in XRCC3 Exon 7 (C18067T, rs861539), IVS5-14 (A17893G, rs1799796), and XRCC7 Intron 8 (G6721T, rs7003908) by polymerase chain reaction-restriction fragment-length polymorphism methods. Variant genotype GG (odds ratio [OR], 2.23; p = 0.003) and combined genotype TG + GG (OR, 1.541; p = 0.049), G allele of XRCC7 Intron 8 (G > T), demonstrated significant risk for PCa (OR, 1.529; p = 0.002). Stratification on bases of Gleason grade and bone metastasis, significant risk with high Gleason grade for CT genotype of XRCC3 Exon 7, and variant genotype GG of XRCC7 Intron 8 were observed. Our results strongly support that common sequence variants (GG) genotype of XRCC7 may increase risk of PCa. G allele being a risk allele in our study also suggests that this polymorphism be used as a marker for the PCa susceptibility." @default.
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• W2014589422 date "2010-11-01" @default.
• W2014589422 modified "2023-09-26" @default.
• W2014589422 title "Polymorphic Variants of DNA Repair Gene <i>XRCC3</i> and <i>XRCC7</i> and Risk of Prostate Cancer: A Study from North Indian Population" @default.
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• W2014589422 doi "https://doi.org/10.1089/dna.2010.1047" @default.
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