Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014591683> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2014591683 endingPage "444" @default.
- W2014591683 startingPage "440" @default.
- W2014591683 abstract "Summary: Using constant infusion technique and a water-loading procedure, we investigated renal hemodynamic and excretional variables in 15 essential hypertensive patients [diastolic blood pressure (DBP) 102 ± 10 mm Hg] after 3 weeks of placebo and after 16 weeks of treatment with a postjunctional α1-adrenoceptor-antagonist, doxazosin (1–16 mg) once daily. A minor decrease in supine DBP (p < 0.05) but no significant changes in systolic BP (SBP) and heart rate (HR) were observed. No significant changes were noted in glomerular filtration rate (GFR), renal plasma flow (RPF), and renal vascular resistance (RVR). The mean renal excretion rate of sodium, potassium, uric acid, and albumin for the entire group was unaffected by the treatment, but the individual changes in sodium clearance correlated significantly with changes in mean BP (r = 0.64, n = 15, p < 0.05). Six patients showed an increase in sodium excretion after treatment, whereas nine showed a decrease. No decrease in mean body weight was noted, but the BP reduction after 5 months of treatment correlated significantly with the changes in body weight (r = 0.62, n = 15, p < 0.01). The results indicate that long-term treatment with doxazosin had no deleterious effect on renal function, but the effects on BP were rather modest. The individual BP response is probably determined by the degree of fluid retention even if an intact pressure-natriuresis relationship could still be demonstrated during chronic therapy." @default.
- W2014591683 created "2016-06-24" @default.
- W2014591683 creator A5036566309 @default.
- W2014591683 creator A5043651342 @default.
- W2014591683 creator A5056126077 @default.
- W2014591683 date "1992-09-01" @default.
- W2014591683 modified "2023-10-12" @default.
- W2014591683 title "α-Adrenoceptor Blockade in Patients with Mild to Moderate Hypertension" @default.
- W2014591683 doi "https://doi.org/10.1097/00005344-199209000-00015" @default.
- W2014591683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1279290" @default.
- W2014591683 hasPublicationYear "1992" @default.
- W2014591683 type Work @default.
- W2014591683 sameAs 2014591683 @default.
- W2014591683 citedByCount "13" @default.
- W2014591683 crossrefType "journal-article" @default.
- W2014591683 hasAuthorship W2014591683A5036566309 @default.
- W2014591683 hasAuthorship W2014591683A5043651342 @default.
- W2014591683 hasAuthorship W2014591683A5056126077 @default.
- W2014591683 hasBestOaLocation W20145916831 @default.
- W2014591683 hasConcept C119584498 @default.
- W2014591683 hasConcept C125567185 @default.
- W2014591683 hasConcept C126322002 @default.
- W2014591683 hasConcept C134018914 @default.
- W2014591683 hasConcept C142225936 @default.
- W2014591683 hasConcept C159641895 @default.
- W2014591683 hasConcept C174459258 @default.
- W2014591683 hasConcept C178853913 @default.
- W2014591683 hasConcept C2777097880 @default.
- W2014591683 hasConcept C2777590997 @default.
- W2014591683 hasConcept C2777953023 @default.
- W2014591683 hasConcept C71924100 @default.
- W2014591683 hasConcept C84393581 @default.
- W2014591683 hasConceptScore W2014591683C119584498 @default.
- W2014591683 hasConceptScore W2014591683C125567185 @default.
- W2014591683 hasConceptScore W2014591683C126322002 @default.
- W2014591683 hasConceptScore W2014591683C134018914 @default.
- W2014591683 hasConceptScore W2014591683C142225936 @default.
- W2014591683 hasConceptScore W2014591683C159641895 @default.
- W2014591683 hasConceptScore W2014591683C174459258 @default.
- W2014591683 hasConceptScore W2014591683C178853913 @default.
- W2014591683 hasConceptScore W2014591683C2777097880 @default.
- W2014591683 hasConceptScore W2014591683C2777590997 @default.
- W2014591683 hasConceptScore W2014591683C2777953023 @default.
- W2014591683 hasConceptScore W2014591683C71924100 @default.
- W2014591683 hasConceptScore W2014591683C84393581 @default.
- W2014591683 hasIssue "3" @default.
- W2014591683 hasLocation W20145916831 @default.
- W2014591683 hasLocation W20145916832 @default.
- W2014591683 hasLocation W20145916833 @default.
- W2014591683 hasOpenAccess W2014591683 @default.
- W2014591683 hasPrimaryLocation W20145916831 @default.
- W2014591683 hasRelatedWork W130173463 @default.
- W2014591683 hasRelatedWork W1417697020 @default.
- W2014591683 hasRelatedWork W1966586800 @default.
- W2014591683 hasRelatedWork W1986155076 @default.
- W2014591683 hasRelatedWork W1996235794 @default.
- W2014591683 hasRelatedWork W2018428587 @default.
- W2014591683 hasRelatedWork W2018798885 @default.
- W2014591683 hasRelatedWork W2048964378 @default.
- W2014591683 hasRelatedWork W2054574878 @default.
- W2014591683 hasRelatedWork W2418809154 @default.
- W2014591683 hasVolume "20" @default.
- W2014591683 isParatext "false" @default.
- W2014591683 isRetracted "false" @default.
- W2014591683 magId "2014591683" @default.
- W2014591683 workType "article" @default.