Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014592004> ?p ?o ?g. }
- W2014592004 endingPage "116" @default.
- W2014592004 startingPage "105" @default.
- W2014592004 abstract "The characteristics of B cell lines isolated from patients with Alzheimer's disease (AD) and age-matched controls were investigated after having been transformed by Epstein-Barr virus (EBV). After isolation of mononuclear blood cells and in vivo or in vitro EBV infection, 35 and 21 lymphoblastoid cell lines (LCLs) were generated from 19 patients with AD (mean age 79.4 years) and 21 age-matched controls (mean age 80.0 years), respectively. B lymphocytes from AD patients were immortalised more easily than those from controls; the percentage of in vitro EBV infected LCLs (B95-LCLs) obtained in the AD group was significantly higher (76.2% versus 33.3% in the control group) and the mean time required for establishment was significantly lower (20.2 and 21.9 days versus 26.7 and 60.9 days in the control group). The EBV receptor and surface immunoglobulin (Ig) analyses showed no difference between the two groups. The expression of Epstein-Barr early antigens (EA) and viral capsid antigens (VCAs) revealed a tendency to higher viral replication in LCLs from AD patients; however, VCA expression remained limited to a small number of cells and did not affect overall cell growth. Finally, qualitative and quantitative differences were observed in the pattern of Ig production. Whereas spontaneously established LCLs from AD patients were generally monoclonal (80% of LCLs versus 33% in the control group), B95-LCLs were all polyclonal and secreted more IgM and IgA than those from controls; the mean IgM level was significantly higher in B95-LCLs from the AD group. These results suggest that B cells derived from AD patients seemed to be less differentiated than cells from age-matched controls." @default.
- W2014592004 created "2016-06-24" @default.
- W2014592004 creator A5020529645 @default.
- W2014592004 creator A5044076763 @default.
- W2014592004 creator A5048348152 @default.
- W2014592004 date "1992-03-01" @default.
- W2014592004 modified "2023-09-27" @default.
- W2014592004 title "Characteristics of Epstein-Barr virus transformed B cell lines from patients with Alzheimer's disease and age-matched controls" @default.
- W2014592004 cites W1504016310 @default.
- W2014592004 cites W1615676850 @default.
- W2014592004 cites W185576865 @default.
- W2014592004 cites W1964062648 @default.
- W2014592004 cites W1970748912 @default.
- W2014592004 cites W1979158332 @default.
- W2014592004 cites W1989674704 @default.
- W2014592004 cites W1991440761 @default.
- W2014592004 cites W1992515694 @default.
- W2014592004 cites W1994681152 @default.
- W2014592004 cites W1998790859 @default.
- W2014592004 cites W2001675578 @default.
- W2014592004 cites W2004882894 @default.
- W2014592004 cites W2010207218 @default.
- W2014592004 cites W2013751340 @default.
- W2014592004 cites W2019826861 @default.
- W2014592004 cites W2030265994 @default.
- W2014592004 cites W2041147522 @default.
- W2014592004 cites W2043093287 @default.
- W2014592004 cites W2047412924 @default.
- W2014592004 cites W2056869155 @default.
- W2014592004 cites W2065207462 @default.
- W2014592004 cites W2069955044 @default.
- W2014592004 cites W2071698914 @default.
- W2014592004 cites W2072642522 @default.
- W2014592004 cites W2081665921 @default.
- W2014592004 cites W2087217749 @default.
- W2014592004 cites W2088993136 @default.
- W2014592004 cites W2090504138 @default.
- W2014592004 cites W2095310635 @default.
- W2014592004 cites W2104227586 @default.
- W2014592004 cites W2105778523 @default.
- W2014592004 cites W2117660994 @default.
- W2014592004 cites W2130036147 @default.
- W2014592004 cites W2130694207 @default.
- W2014592004 cites W2140212557 @default.
- W2014592004 cites W2146911578 @default.
- W2014592004 cites W2166797577 @default.
- W2014592004 cites W2176256304 @default.
- W2014592004 cites W2366563204 @default.
- W2014592004 cites W2409088700 @default.
- W2014592004 cites W2415245714 @default.
- W2014592004 cites W4244678912 @default.
- W2014592004 doi "https://doi.org/10.1016/0047-6374(92)90020-e" @default.
- W2014592004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1318479" @default.
- W2014592004 hasPublicationYear "1992" @default.
- W2014592004 type Work @default.
- W2014592004 sameAs 2014592004 @default.
- W2014592004 citedByCount "15" @default.
- W2014592004 countsByYear W20145920042013 @default.
- W2014592004 countsByYear W20145920042016 @default.
- W2014592004 countsByYear W20145920042017 @default.
- W2014592004 countsByYear W20145920042019 @default.
- W2014592004 countsByYear W20145920042022 @default.
- W2014592004 crossrefType "journal-article" @default.
- W2014592004 hasAuthorship W2014592004A5020529645 @default.
- W2014592004 hasAuthorship W2014592004A5044076763 @default.
- W2014592004 hasAuthorship W2014592004A5048348152 @default.
- W2014592004 hasConcept C137061746 @default.
- W2014592004 hasConcept C147483822 @default.
- W2014592004 hasConcept C159047783 @default.
- W2014592004 hasConcept C159654299 @default.
- W2014592004 hasConcept C202751555 @default.
- W2014592004 hasConcept C203014093 @default.
- W2014592004 hasConcept C207001950 @default.
- W2014592004 hasConcept C2522874641 @default.
- W2014592004 hasConcept C2776409557 @default.
- W2014592004 hasConcept C2778847070 @default.
- W2014592004 hasConcept C2780727368 @default.
- W2014592004 hasConcept C2781375147 @default.
- W2014592004 hasConcept C54355233 @default.
- W2014592004 hasConcept C86803240 @default.
- W2014592004 hasConcept C956191 @default.
- W2014592004 hasConceptScore W2014592004C137061746 @default.
- W2014592004 hasConceptScore W2014592004C147483822 @default.
- W2014592004 hasConceptScore W2014592004C159047783 @default.
- W2014592004 hasConceptScore W2014592004C159654299 @default.
- W2014592004 hasConceptScore W2014592004C202751555 @default.
- W2014592004 hasConceptScore W2014592004C203014093 @default.
- W2014592004 hasConceptScore W2014592004C207001950 @default.
- W2014592004 hasConceptScore W2014592004C2522874641 @default.
- W2014592004 hasConceptScore W2014592004C2776409557 @default.
- W2014592004 hasConceptScore W2014592004C2778847070 @default.
- W2014592004 hasConceptScore W2014592004C2780727368 @default.
- W2014592004 hasConceptScore W2014592004C2781375147 @default.
- W2014592004 hasConceptScore W2014592004C54355233 @default.
- W2014592004 hasConceptScore W2014592004C86803240 @default.
- W2014592004 hasConceptScore W2014592004C956191 @default.
- W2014592004 hasIssue "1" @default.
- W2014592004 hasLocation W20145920041 @default.