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- W2014594377 endingPage "429" @default.
- W2014594377 startingPage "397" @default.
- W2014594377 abstract "Bleeding and thrombotic complications are important causes of morbidity and mortality in critically ill patients with cancer. The prevalence of these complications has increased progressively in recent years as a result of improvements in cancer treatment, which increase the exposure of patients to these risks, and of advances in critical care. The exact incidence of bleeding in patients with cancer admitted to the intensive care unit (ICU) is not known. In general, bleeding complications occur relatively infrequently in patients with solid tumors other than malignant melanoma, germ cell tumors, and prostate cancer.50, 53, 130, 132 Bleeding is common in patients with leukemias, particularly in patients with acute promyelocytic leukemia as many as 90% of whom may develop hemorrhage.6, 90, 115 Hemostatic changes leading to a prothrombotic state may occur in more than 90% of patients with cancer.115 In addition, venous thromboembolism is encountered at postmortem examination in approximately 50% of patients with cancer.41The practice of critical care oncology requires that the intensivist have a working knowledge of the various hemostatic reactions that occur in acutely ill patients with cancer. This article reviews the physiology of normal hemostasis and then discusses the relationship of the coagulation system and cancer. The pathophysiology of bleeding and thrombosis in the patient with cancer are reviewed along with the diagnostic and treatment approaches to the disorders most frequently encountered in patients with cancer admitted to the ICU. Finally, the potential usefulness of recombinant factor VII concentrate, a novel clotting agent, in patients with cancer is reviewed." @default.
- W2014594377 created "2016-06-24" @default.
- W2014594377 creator A5057261493 @default.
- W2014594377 date "1996-04-01" @default.
- W2014594377 modified "2023-10-16" @default.
- W2014594377 title "TRANSFUSION AND STEM CELL SUPPORT IN CANCER TREATMENT" @default.
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