FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014597264> ?p ?o ?g. }

• W2014597264 endingPage "282" @default.
• W2014597264 startingPage "269" @default.
• W2014597264 abstract "There is controversy about whether axotomized neurons undergo death or only severe atrophy after spinal cord injury (SCI) in mammals. Lampreys recover from complete spinal transection, but only about half of the severed spinal-projecting axons regenerate through the site of injury. The fates of the unregenerated neurons remain unknown, and until now death of axotomized spinal-projecting neurons has not been described in the lamprey brain. We now report that in animals allowed to survive for 12 or more weeks after spinal cord transection, several identified reticulospinal (RS) neurons were missing in Nissl-stained or neurofilament-immunostained brain whole mounts. At earlier times, these neurons were swollen and pale in Nissl-stained preparations. Retrograde fluorescent labeling from the site of transection combined with TUNEL histochemistry suggested that neuronal death, including that of the identified RS neurons, began in animals 4 weeks posttransection, reaching a peak at 12-16 weeks. This was not seen in untransected animals. The TUNEL positivity suggests that some cells were dying by apoptosis. Of special interest, among the identified neurons, this delayed cell death was restricted to neurons that at earlier posttransection times have a low probability of regeneration. These data show that SCI induces delayed cell death in lamprey spinal-projecting neurons and suggest that the reason why some neurons are bad regenerators is that they are already undergoing apoptotic cell death. Thus protection from apoptosis may be necessary in order to enhance axonal regeneration after SCI." @default.
• W2014597264 created "2016-06-24" @default.
• W2014597264 creator A5021861521 @default.
• W2014597264 creator A5043819159 @default.
• W2014597264 creator A5044913317 @default.
• W2014597264 date "2008-09-20" @default.
• W2014597264 modified "2023-09-24" @default.
• W2014597264 title "Delayed death of identified reticulospinal neurons after spinal cord injury in lampreys" @default.
• W2014597264 cites W142080826 @default.
• W2014597264 cites W1626927875 @default.
• W2014597264 cites W1890592137 @default.
• W2014597264 cites W1892717557 @default.
• W2014597264 cites W1906407967 @default.
• W2014597264 cites W1947528063 @default.
• W2014597264 cites W1965430627 @default.
• W2014597264 cites W1969226019 @default.
• W2014597264 cites W1973354555 @default.
• W2014597264 cites W1974538282 @default.
• W2014597264 cites W1976144105 @default.
• W2014597264 cites W1982598770 @default.
• W2014597264 cites W1983980546 @default.
• W2014597264 cites W1984509756 @default.
• W2014597264 cites W1994576873 @default.
• W2014597264 cites W1994929780 @default.
• W2014597264 cites W1996327998 @default.
• W2014597264 cites W1997610777 @default.
• W2014597264 cites W1998769611 @default.
• W2014597264 cites W2000078809 @default.
• W2014597264 cites W2006162209 @default.
• W2014597264 cites W2007422763 @default.
• W2014597264 cites W2013709298 @default.
• W2014597264 cites W2014032127 @default.
• W2014597264 cites W2017323731 @default.
• W2014597264 cites W2024622652 @default.
• W2014597264 cites W2027360386 @default.
• W2014597264 cites W2030848480 @default.
• W2014597264 cites W2032079164 @default.
• W2014597264 cites W2047317904 @default.
• W2014597264 cites W2047848191 @default.
• W2014597264 cites W2053961518 @default.
• W2014597264 cites W2055265965 @default.
• W2014597264 cites W2055563751 @default.
• W2014597264 cites W2055729073 @default.
• W2014597264 cites W2060808339 @default.
• W2014597264 cites W2065817654 @default.
• W2014597264 cites W2066176521 @default.
• W2014597264 cites W2069128679 @default.
• W2014597264 cites W2070182735 @default.
• W2014597264 cites W2071689238 @default.
• W2014597264 cites W2078635367 @default.
• W2014597264 cites W2080432557 @default.
• W2014597264 cites W2080618765 @default.
• W2014597264 cites W2082963544 @default.
• W2014597264 cites W2093814006 @default.
• W2014597264 cites W2095146312 @default.
• W2014597264 cites W2100045176 @default.
• W2014597264 cites W2101982692 @default.
• W2014597264 cites W2116974827 @default.
• W2014597264 cites W2122080265 @default.
• W2014597264 cites W2128945056 @default.
• W2014597264 cites W2133055989 @default.
• W2014597264 cites W2135406143 @default.
• W2014597264 cites W2141296392 @default.
• W2014597264 cites W2162769562 @default.
• W2014597264 cites W2170131359 @default.
• W2014597264 cites W2272201577 @default.
• W2014597264 cites W2303153891 @default.
• W2014597264 cites W4298413215 @default.
• W2014597264 cites W907510603 @default.
• W2014597264 doi "https://doi.org/10.1002/cne.21789" @default.
• W2014597264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18634003" @default.
• W2014597264 hasPublicationYear "2008" @default.
• W2014597264 type Work @default.
• W2014597264 sameAs 2014597264 @default.
• W2014597264 citedByCount "61" @default.
• W2014597264 countsByYear W20145972642012 @default.
• W2014597264 countsByYear W20145972642013 @default.
• W2014597264 countsByYear W20145972642014 @default.
• W2014597264 countsByYear W20145972642015 @default.
• W2014597264 countsByYear W20145972642016 @default.
• W2014597264 countsByYear W20145972642017 @default.
• W2014597264 countsByYear W20145972642018 @default.
• W2014597264 countsByYear W20145972642019 @default.
• W2014597264 countsByYear W20145972642020 @default.
• W2014597264 countsByYear W20145972642021 @default.
• W2014597264 countsByYear W20145972642022 @default.
• W2014597264 countsByYear W20145972642023 @default.
• W2014597264 crossrefType "journal-article" @default.
• W2014597264 hasAuthorship W2014597264A5021861521 @default.
• W2014597264 hasAuthorship W2014597264A5043819159 @default.
• W2014597264 hasAuthorship W2014597264A5044913317 @default.
• W2014597264 hasConcept C105702510 @default.
• W2014597264 hasConcept C142724271 @default.
• W2014597264 hasConcept C169760540 @default.
• W2014597264 hasConcept C190283241 @default.
• W2014597264 hasConcept C196795494 @default.
• W2014597264 hasConcept C2778334475 @default.
• W2014597264 hasConcept C2778794669 @default.

• next