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• W2014598274 abstract "Objective Granulomatosis with polyangiitis (GPA), also known as Wegener's granulomatosis, is an autoimmune disease characterized by inflammation of blood vessels most often seen in the upper respiratory tract, lungs, kidneys, and skin. Central nervous system (CNS) involvement of GPA is rare, particularly in the pituitary, and can be difficult to treat. Methods Case report. Results We present a 30-year-old woman with pituitary and ocular GPA, whose unusually recalcitrant disease led to the development of pan-hypopituitarism and neartotal vision loss. After failing multiple systemic immunosuppressants, she was ultimately treated with the novel immunomodulatory agent rituximab together with pulse corticosteroids, which achieved a gratifying response. Conclusion Pituitary and optic chiasm involvement is a rare complication of GPA. We believe this case illustrates the complexity of management of pituitary GPA and provides insight into the potential utility of the biologic agent rituximab in this disease. (Endocr Pract. 2013;19:e1-e7)" @default.
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• W2014598274 date "2013-01-01" @default.
• W2014598274 modified "2023-10-03" @default.
• W2014598274 title "Refractory Pituitary Granulomatosis with Polyangiitis (Wegener's) Treated with Rituximab" @default.
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• W2014598274 doi "https://doi.org/10.4158/ep12181.cr" @default.
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