FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014600611> ?p ?o ?g. }

• W2014600611 abstract "Fresh rat aortic rings were incubated in HEPES-buffered salt solutions. Extracellular Ca2+ stimulated the production of prostacyclin (PGI2), as determined by radioimmunoassay of its stable hydrolysis product 6-oxo-prostaglandin F1 alpha. This action of Ca2+ was modified by H+ over the pH range 8.0-6.5. Stimulation by calcium ionophore A23187 was not pH-dependent. In parallel incubations of aortic rings with 45Ca2+, followed by washing in the presence of La3+, tissue uptake of 45Ca2+ increased progressively as extracellular pH was increased from 6.5-8.0. Over this range intracellular pH, estimated by the distribution of [14C]-dimethadione, varied from 5.9-7.4. Stimulation by Ca2+ of PGI2 synthesis was concentration-dependent over the range 0.7-20 mM. The maximum effect was an increase of approx. 4 fold. Nifedipine, but not verapamil or diltiazem, inhibited Ca2+-stimulated PGI2 synthesis. A dihydropyridine compound that activates voltage-dependent Ca2+ channels, Bay K 8644, did not increase PGI2 synthesis. 8-(N, N-diethylamino)-octyl-3,4,5 timethoxybenzoate (TMB-8), an antagonist of intracellular Ca2+ mobilisation, inhibited basal and Ca2+-stimulated PGI2 synthesis to a similar extent. A solution containing 40 mM K+ reduced Ca2+-stimulated PGI2 production. Mg2+ stimulated PGI2 synthesis in a pH-dependent manner but was less potent than Ca2+. Other divalent cations (Mn2+, Ba2+ and Sr2+), and La3+ had little or no effect on basal or Ca2+-stimulated PGI2 synthesis." @default.
• W2014600611 created "2016-06-24" @default.
• W2014600611 creator A5021529820 @default.
• W2014600611 creator A5034466911 @default.
• W2014600611 creator A5072392170 @default.
• W2014600611 date "1987-06-01" @default.
• W2014600611 modified "2023-09-23" @default.
• W2014600611 title "pH-dependent stimulation by Ca2+ of prostacyclin synthesis in rat aortic rings: effects of drugs and inorganic ions" @default.
• W2014600611 cites W1968219103 @default.
• W2014600611 cites W1977619845 @default.
• W2014600611 cites W1980581864 @default.
• W2014600611 cites W1984787065 @default.
• W2014600611 cites W1994385501 @default.
• W2014600611 cites W2000774953 @default.
• W2014600611 cites W2002403163 @default.
• W2014600611 cites W2007030127 @default.
• W2014600611 cites W2007927156 @default.
• W2014600611 cites W2012187456 @default.
• W2014600611 cites W2012861488 @default.
• W2014600611 cites W2013965621 @default.
• W2014600611 cites W2030768867 @default.
• W2014600611 cites W2035250617 @default.
• W2014600611 cites W2035371116 @default.
• W2014600611 cites W2037583120 @default.
• W2014600611 cites W2041985792 @default.
• W2014600611 cites W2044362463 @default.
• W2014600611 cites W2050919472 @default.
• W2014600611 cites W2052616985 @default.
• W2014600611 cites W2061056399 @default.
• W2014600611 cites W2061755142 @default.
• W2014600611 cites W2063859742 @default.
• W2014600611 cites W2079621018 @default.
• W2014600611 cites W2089704418 @default.
• W2014600611 cites W2089810309 @default.
• W2014600611 cites W2096120477 @default.
• W2014600611 cites W2132184473 @default.
• W2014600611 cites W2142146022 @default.
• W2014600611 cites W2148682759 @default.
• W2014600611 cites W2173520866 @default.
• W2014600611 cites W2174557534 @default.
• W2014600611 cites W2226437153 @default.
• W2014600611 cites W2315103172 @default.
• W2014600611 cites W2338323241 @default.
• W2014600611 cites W2469922085 @default.
• W2014600611 cites W4253920845 @default.
• W2014600611 doi "https://doi.org/10.1111/j.1476-5381.1987.tb10299.x" @default.
• W2014600611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1853509" @default.
• W2014600611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3300833" @default.
• W2014600611 hasPublicationYear "1987" @default.
• W2014600611 type Work @default.
• W2014600611 sameAs 2014600611 @default.
• W2014600611 citedByCount "22" @default.
• W2014600611 countsByYear W20146006112012 @default.
• W2014600611 crossrefType "journal-article" @default.
• W2014600611 hasAuthorship W2014600611A5021529820 @default.
• W2014600611 hasAuthorship W2014600611A5034466911 @default.
• W2014600611 hasAuthorship W2014600611A5072392170 @default.
• W2014600611 hasBestOaLocation W20146006112 @default.
• W2014600611 hasConcept C12554922 @default.
• W2014600611 hasConcept C134018914 @default.
• W2014600611 hasConcept C178790620 @default.
• W2014600611 hasConcept C185592680 @default.
• W2014600611 hasConcept C24998067 @default.
• W2014600611 hasConcept C2777022698 @default.
• W2014600611 hasConcept C2779014961 @default.
• W2014600611 hasConcept C2779066535 @default.
• W2014600611 hasConcept C2780664492 @default.
• W2014600611 hasConcept C2781128415 @default.
• W2014600611 hasConcept C28406088 @default.
• W2014600611 hasConcept C519063684 @default.
• W2014600611 hasConcept C55493867 @default.
• W2014600611 hasConcept C74884574 @default.
• W2014600611 hasConcept C79879829 @default.
• W2014600611 hasConcept C86803240 @default.
• W2014600611 hasConceptScore W2014600611C12554922 @default.
• W2014600611 hasConceptScore W2014600611C134018914 @default.
• W2014600611 hasConceptScore W2014600611C178790620 @default.
• W2014600611 hasConceptScore W2014600611C185592680 @default.
• W2014600611 hasConceptScore W2014600611C24998067 @default.
• W2014600611 hasConceptScore W2014600611C2777022698 @default.
• W2014600611 hasConceptScore W2014600611C2779014961 @default.
• W2014600611 hasConceptScore W2014600611C2779066535 @default.
• W2014600611 hasConceptScore W2014600611C2780664492 @default.
• W2014600611 hasConceptScore W2014600611C2781128415 @default.
• W2014600611 hasConceptScore W2014600611C28406088 @default.
• W2014600611 hasConceptScore W2014600611C519063684 @default.
• W2014600611 hasConceptScore W2014600611C55493867 @default.
• W2014600611 hasConceptScore W2014600611C74884574 @default.
• W2014600611 hasConceptScore W2014600611C79879829 @default.
• W2014600611 hasConceptScore W2014600611C86803240 @default.
• W2014600611 hasLocation W20146006111 @default.
• W2014600611 hasLocation W20146006112 @default.
• W2014600611 hasLocation W20146006113 @default.
• W2014600611 hasLocation W20146006114 @default.
• W2014600611 hasOpenAccess W2014600611 @default.
• W2014600611 hasPrimaryLocation W20146006111 @default.
• W2014600611 hasRelatedWork W139870775 @default.
• W2014600611 hasRelatedWork W1777997311 @default.
• W2014600611 hasRelatedWork W1995216096 @default.
• W2014600611 hasRelatedWork W2009298563 @default.

• next