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• W2014603468 abstract "We tried to assess the long-term efficacy and outcome of low through level of calcineurin inhibitors (CNI) and introducing mycophenolate mofetil (MMF) in liver transplant (LT) patients with CNI-related renal dysfunction. Pts were matched for sex, age, months after LT, immunosuppressive treatment, creatinine level, presence of diabetes and calculated glomerular filtration rate (GFR) via Cockroft-Gault method, with a parallel control group who had received CNI only. We analysed: side effects, rate of rejection, serum creatinine reduction by at least 10% (10% creatinine) and/or a GFR increase of at least 10% (10% GFR) with respect to baseline values, Δserum creatinine (serum creatinine level at baseline–serum creatinine level at 24 month), ΔGFR (GFR at 24 month–GFR at baseline). Thirty patients (25 M; mean age 61 ± 7 years; creatinine 1.77 ± 0.51 mg/dl; GFR 48.4 ± 14 ml/min) were converted to the combined therapy after a median of 63 months from LT and were compared with 30 patients (mean age 60 ± 7 years; creatinine 1.62 ± 0.25 mg/dl; GFR 48.9 ± 11.2 ml/min) used as contemporary control group. After 2 years, serum creatinine decreased in the MMF to 1.57 ± 0.71 mg/dl and GFR increased to 56.8 ± 17.2 ml/min (p < 0.001). The controls experienced a worsening of both serum creatinine (1.7 ± 0.35 mg/dl; p = 0.013) and GFR (47.3 ± 11.1 ml/min; p = 0.006). The logistic regression models employing 10% creatinine and 10% GFR as dependent variables, showed the use of MMF as the only statistically significant parameter associated with improvement of renal function (OR 5.7/95% CI 1.7–18.9, p = 0.004; OR 3.8/95% CI 1.2–11.4, p = 0.019, respectively). Multiple linear regression analysis identified only MMF as independent predictor of Δcreatinine and ΔGFR (regression coefficient B: −0.26/95% CI −0.1/−0.41; p = 0.002; −9.05/95% CI −4.9/−13.2; p < 0.001, respectively). No rejection episode was observed (3 in the controls). This study demonstrates the long-term efficacy and safety of MMF plus low dose CNI in reducing nephrotoxicity in LT recipients." @default.
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• W2014603468 date "2007-10-01" @default.
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• W2014603468 title "Mycophenolate mofetil plus low-dose calcineurin inhibitor for renal dysfunction in liver transplant: A 24-month controlled clinical trial" @default.
• W2014603468 doi "https://doi.org/10.1016/j.dld.2007.07.015" @default.
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