Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014603715> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2014603715 endingPage "555" @default.
- W2014603715 startingPage "549" @default.
- W2014603715 abstract "To probe the interplay between radiotracer stability and somatostatin receptor affinity, Tyr(3)-octreotate and six variations of its peptide sequence, for which the Re-cyclized products were previously reported, were radiolabeled with (99m)Tc and investigated for their in vitro stability.Radiolabeling of the peptides was effected by ligand exchange from (99m)Tc-glucoheptonate, and the desired products were purified by radio-RP-HPLC. The in vitro stability in phosphate buffered saline, mouse serum and cysteine solutions at physiological temperature and pH for all seven (99m)Tc-cyclized peptides was determined by radio-RP-HPLC and radio-TLC. Normal CF-1 mouse biodistribution studies were performed for three of the (99m)Tc-cyclized peptides.Based on the fully characterized Re-cyclized peptide analogues, four (99m)Tc-coordination motifs were proposed for the (99m)Tc-cyclized peptides. Technetium-99m-cyclized Tyr(3)-octreotate derivatives with N(2)S(2) metal coordination modes and large metal ring sizes were susceptible to oxidation and loss of (99m)Tc in the form of (99m)TcO(4)(-), as evidenced by their instability in the various solutions under physiological conditions (15-58% intact at 24 h). As anticipated, the addition of a third cysteine to the sequence stabilized the (99m)Tc metal coordination, and peptides with NS(3) coordination modes remained >85% intact out to 24 h. No significant differences were observed in the biodistribution studies performed with three peptides of varying stabilities.Improvements in stability were not sufficient to outweigh the low somatostatin receptor affinity for the peptides in this study. Further improvements in the peptide sequence and/or metal coordination are needed to result in a radiodiagnostic/radiotherapeutic pair for targeting the somatostatin receptor." @default.
- W2014603715 created "2016-06-24" @default.
- W2014603715 creator A5002671174 @default.
- W2014603715 creator A5017332907 @default.
- W2014603715 creator A5037961845 @default.
- W2014603715 creator A5040779098 @default.
- W2014603715 creator A5053225214 @default.
- W2014603715 creator A5058337709 @default.
- W2014603715 date "2011-05-01" @default.
- W2014603715 modified "2023-10-14" @default.
- W2014603715 title "Labeling, stability and biodistribution studies of 99mTc-cyclized Tyr3-octreotate derivatives" @default.
- W2014603715 cites W1503754384 @default.
- W2014603715 cites W1973069842 @default.
- W2014603715 cites W1982055976 @default.
- W2014603715 cites W1985061998 @default.
- W2014603715 cites W1995823770 @default.
- W2014603715 cites W1996443691 @default.
- W2014603715 cites W2014118737 @default.
- W2014603715 cites W2024630504 @default.
- W2014603715 cites W2041174595 @default.
- W2014603715 cites W2067142819 @default.
- W2014603715 cites W2087560097 @default.
- W2014603715 cites W2138185928 @default.
- W2014603715 doi "https://doi.org/10.1016/j.nucmedbio.2010.10.006" @default.
- W2014603715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3086726" @default.
- W2014603715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21531292" @default.
- W2014603715 hasPublicationYear "2011" @default.
- W2014603715 type Work @default.
- W2014603715 sameAs 2014603715 @default.
- W2014603715 citedByCount "15" @default.
- W2014603715 countsByYear W20146037152013 @default.
- W2014603715 countsByYear W20146037152014 @default.
- W2014603715 countsByYear W20146037152016 @default.
- W2014603715 countsByYear W20146037152017 @default.
- W2014603715 countsByYear W20146037152018 @default.
- W2014603715 countsByYear W20146037152020 @default.
- W2014603715 countsByYear W20146037152021 @default.
- W2014603715 countsByYear W20146037152023 @default.
- W2014603715 crossrefType "journal-article" @default.
- W2014603715 hasAuthorship W2014603715A5002671174 @default.
- W2014603715 hasAuthorship W2014603715A5017332907 @default.
- W2014603715 hasAuthorship W2014603715A5037961845 @default.
- W2014603715 hasAuthorship W2014603715A5040779098 @default.
- W2014603715 hasAuthorship W2014603715A5053225214 @default.
- W2014603715 hasAuthorship W2014603715A5058337709 @default.
- W2014603715 hasBestOaLocation W20146037152 @default.
- W2014603715 hasConcept C116569031 @default.
- W2014603715 hasConcept C169760540 @default.
- W2014603715 hasConcept C170493617 @default.
- W2014603715 hasConcept C181199279 @default.
- W2014603715 hasConcept C185592680 @default.
- W2014603715 hasConcept C202751555 @default.
- W2014603715 hasConcept C2776297358 @default.
- W2014603715 hasConcept C2777807558 @default.
- W2014603715 hasConcept C2779201268 @default.
- W2014603715 hasConcept C2779281246 @default.
- W2014603715 hasConcept C55493867 @default.
- W2014603715 hasConcept C71240020 @default.
- W2014603715 hasConcept C86803240 @default.
- W2014603715 hasConceptScore W2014603715C116569031 @default.
- W2014603715 hasConceptScore W2014603715C169760540 @default.
- W2014603715 hasConceptScore W2014603715C170493617 @default.
- W2014603715 hasConceptScore W2014603715C181199279 @default.
- W2014603715 hasConceptScore W2014603715C185592680 @default.
- W2014603715 hasConceptScore W2014603715C202751555 @default.
- W2014603715 hasConceptScore W2014603715C2776297358 @default.
- W2014603715 hasConceptScore W2014603715C2777807558 @default.
- W2014603715 hasConceptScore W2014603715C2779201268 @default.
- W2014603715 hasConceptScore W2014603715C2779281246 @default.
- W2014603715 hasConceptScore W2014603715C55493867 @default.
- W2014603715 hasConceptScore W2014603715C71240020 @default.
- W2014603715 hasConceptScore W2014603715C86803240 @default.
- W2014603715 hasFunder F4320332161 @default.
- W2014603715 hasIssue "4" @default.
- W2014603715 hasLocation W20146037151 @default.
- W2014603715 hasLocation W20146037152 @default.
- W2014603715 hasLocation W20146037153 @default.
- W2014603715 hasLocation W20146037154 @default.
- W2014603715 hasOpenAccess W2014603715 @default.
- W2014603715 hasPrimaryLocation W20146037151 @default.
- W2014603715 hasRelatedWork W1980377213 @default.
- W2014603715 hasRelatedWork W2016368229 @default.
- W2014603715 hasRelatedWork W2050762082 @default.
- W2014603715 hasRelatedWork W2092164820 @default.
- W2014603715 hasRelatedWork W2097240451 @default.
- W2014603715 hasRelatedWork W2390942677 @default.
- W2014603715 hasRelatedWork W2467234707 @default.
- W2014603715 hasRelatedWork W2739417245 @default.
- W2014603715 hasRelatedWork W2952244581 @default.
- W2014603715 hasRelatedWork W3207404993 @default.
- W2014603715 hasVolume "38" @default.
- W2014603715 isParatext "false" @default.
- W2014603715 isRetracted "false" @default.
- W2014603715 magId "2014603715" @default.
- W2014603715 workType "article" @default.