Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014608817> ?p ?o ?g. }
- W2014608817 endingPage "48" @default.
- W2014608817 startingPage "40" @default.
- W2014608817 abstract "Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are important causes of blindness among children and working-age adults, respectively. The development of both diseases involves retinal microvascular degeneration, vessel loss and consequent hypoxic and inflammatory pathologic retinal neovascularization. Mechanistic studies have shown that oxidative stress and subsequent derangement of cell signaling are important factors in disease progression. In eye and vision research, role of the dietary xanthophyll carotenoids, lutein and zeaxanthin, has been more extensively studied in adult onset macular degeneration than these other retinopathies. These carotenoids also may decrease severity of ROP in preterm infants and of DR in working-age adults. A randomized controlled clinical trial of carotenoid supplementation in preterm infants indicated that lutein has functional effects in the neonatal eye and is anti-inflammatory. Three multicenter clinical trials all showed a trend of decreased ROP severity in the lutein supplemented group. Prospective studies on patients with non-proliferative DR indicate serum levels of lutein and zeaxanthin are significantly lower in these patients compared to normal subjects. The present review describes recent advances in lutein and zeaxanthin modulation of oxidative stress and inflammation related to ROP and DR and discusses potential roles of lutein/zeaxanthin in preventing or lessening the risks of disease initiation or progression." @default.
- W2014608817 created "2016-06-24" @default.
- W2014608817 creator A5045803518 @default.
- W2014608817 creator A5086497534 @default.
- W2014608817 date "2015-04-01" @default.
- W2014608817 modified "2023-10-11" @default.
- W2014608817 title "Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy" @default.
- W2014608817 cites W1447000644 @default.
- W2014608817 cites W1499143025 @default.
- W2014608817 cites W1504527758 @default.
- W2014608817 cites W1531693639 @default.
- W2014608817 cites W1536097609 @default.
- W2014608817 cites W1562028693 @default.
- W2014608817 cites W1583068153 @default.
- W2014608817 cites W1656028612 @default.
- W2014608817 cites W168121840 @default.
- W2014608817 cites W176812056 @default.
- W2014608817 cites W1893604998 @default.
- W2014608817 cites W1895653831 @default.
- W2014608817 cites W1912203308 @default.
- W2014608817 cites W1932876253 @default.
- W2014608817 cites W1964888410 @default.
- W2014608817 cites W1965635843 @default.
- W2014608817 cites W1966811228 @default.
- W2014608817 cites W1968262211 @default.
- W2014608817 cites W1969073905 @default.
- W2014608817 cites W1970971784 @default.
- W2014608817 cites W1971090773 @default.
- W2014608817 cites W1971233637 @default.
- W2014608817 cites W1974302241 @default.
- W2014608817 cites W1976485943 @default.
- W2014608817 cites W1980700229 @default.
- W2014608817 cites W1981664971 @default.
- W2014608817 cites W1982841054 @default.
- W2014608817 cites W1985048688 @default.
- W2014608817 cites W1986827231 @default.
- W2014608817 cites W1987154388 @default.
- W2014608817 cites W1987623536 @default.
- W2014608817 cites W1988230638 @default.
- W2014608817 cites W1989243538 @default.
- W2014608817 cites W1992047040 @default.
- W2014608817 cites W1994148925 @default.
- W2014608817 cites W1994340065 @default.
- W2014608817 cites W1995705179 @default.
- W2014608817 cites W1995822935 @default.
- W2014608817 cites W1998726711 @default.
- W2014608817 cites W1998852117 @default.
- W2014608817 cites W1999098395 @default.
- W2014608817 cites W2000054651 @default.
- W2014608817 cites W2002330978 @default.
- W2014608817 cites W2002600251 @default.
- W2014608817 cites W2002675245 @default.
- W2014608817 cites W2003996544 @default.
- W2014608817 cites W2004186982 @default.
- W2014608817 cites W2005159244 @default.
- W2014608817 cites W2005767645 @default.
- W2014608817 cites W2008160563 @default.
- W2014608817 cites W2011015208 @default.
- W2014608817 cites W2011907306 @default.
- W2014608817 cites W2014472669 @default.
- W2014608817 cites W2015236302 @default.
- W2014608817 cites W2015920746 @default.
- W2014608817 cites W2016771667 @default.
- W2014608817 cites W2016777097 @default.
- W2014608817 cites W2022032959 @default.
- W2014608817 cites W2025980027 @default.
- W2014608817 cites W2027352561 @default.
- W2014608817 cites W2029557435 @default.
- W2014608817 cites W2030119563 @default.
- W2014608817 cites W2034548183 @default.
- W2014608817 cites W2037198872 @default.
- W2014608817 cites W2037517553 @default.
- W2014608817 cites W2040218897 @default.
- W2014608817 cites W2042068980 @default.
- W2014608817 cites W2044437167 @default.
- W2014608817 cites W2049036672 @default.
- W2014608817 cites W2049378419 @default.
- W2014608817 cites W2051276620 @default.
- W2014608817 cites W2052260720 @default.
- W2014608817 cites W2052372105 @default.
- W2014608817 cites W2053098204 @default.
- W2014608817 cites W2056752509 @default.
- W2014608817 cites W2057328170 @default.
- W2014608817 cites W2060787577 @default.
- W2014608817 cites W2061127247 @default.
- W2014608817 cites W2062925687 @default.
- W2014608817 cites W2063752953 @default.
- W2014608817 cites W2064147974 @default.
- W2014608817 cites W2066784383 @default.
- W2014608817 cites W2067074406 @default.
- W2014608817 cites W2075158118 @default.
- W2014608817 cites W2078485696 @default.
- W2014608817 cites W2079276857 @default.
- W2014608817 cites W2079638284 @default.
- W2014608817 cites W2081122945 @default.
- W2014608817 cites W2081968241 @default.
- W2014608817 cites W2082442997 @default.
- W2014608817 cites W2082850007 @default.