FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014610710> ?p ?o ?g. }

• W2014610710 endingPage "135" @default.
• W2014610710 startingPage "127" @default.
• W2014610710 abstract "Single nucleotide polymorphisms (SNPs) in genes related to the biological response to radiation injury may affect clinical normal tissue radiosensitivity. This study investigates whether seven selected SNPs in five candidate genes influence risk of subcutaneous fibrosis and telangiectasia after radiotherapy.The 41 patients included in this study were given post-mastectomy radiotherapy in 1978-1982 and subsequently evaluated in detail with regard to several different normal tissue reactions. SNPs in TGFB1 (codons 10, 25 and position -509), SOD2 (codon 16), XRCC3 (codon 241), XRCC1 (codon 399) and APEX (codon 148) were analyzed by PCR and single nucleotide primer extension. Dose-response curves were established for subcutaneous fibrosis and telangiectasia in patients with different genotypes. Differences in radiosensitivity were quantified in terms of ED(50) values and enhancement ratios.For TGFB1, the Pro/Pro genotype in codon 10 and the T/T genotype in position -509 correlated positively with risk of subcutaneous fibrosis. The SOD 2 codon 16 Val/Ala genotype was associated with increased risk of subcutaneous fibrosis when compared to the Val/Val genotype. The Thr/Thr genotype in XRCC3 codon 241 correlated with increased risk of subcutaneous fibrosis as well as telangiectasia. The Arg/Arg genotype in XRCC1 codon 399 was associated with increased risk of radiation-induced subcutaneous fibrosis. For these polymorphisms, enhancement ratios between 1.09 and 1.25 were found. Combined analysis of multiple SNPs demonstrated that the risk of subcutaneous fibrosis correlated with the number of risk alleles in such a manner that patients with few risk alleles exhibited a remarkable degree of radioresistance.The present study established significant correlations between five SNPs and risk of radiation-induced normal tissue reactions. These findings support the assumption that clinical normal tissue radiosensitivity should be regarded as a phenomenon dependent on the combined effect of variation in several genes and indicate that models based on multiple genetic markers may have the potential to predict normal tissue responses after radiotherapy." @default.
• W2014610710 created "2016-06-24" @default.
• W2014610710 creator A5071977658 @default.
• W2014610710 creator A5073129301 @default.
• W2014610710 creator A5080417921 @default.
• W2014610710 creator A5086242617 @default.
• W2014610710 date "2003-11-01" @default.
• W2014610710 modified "2023-09-27" @default.
• W2014610710 title "Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes" @default.
• W2014610710 cites W1545824776 @default.
• W2014610710 cites W1964013603 @default.
• W2014610710 cites W1977932650 @default.
• W2014610710 cites W1978937876 @default.
• W2014610710 cites W1983585864 @default.
• W2014610710 cites W1985358192 @default.
• W2014610710 cites W1990544379 @default.
• W2014610710 cites W1992107685 @default.
• W2014610710 cites W1996044070 @default.
• W2014610710 cites W1996585676 @default.
• W2014610710 cites W2001506923 @default.
• W2014610710 cites W2004095609 @default.
• W2014610710 cites W2007140114 @default.
• W2014610710 cites W2016296894 @default.
• W2014610710 cites W2028648537 @default.
• W2014610710 cites W2034508361 @default.
• W2014610710 cites W2040293314 @default.
• W2014610710 cites W2052652601 @default.
• W2014610710 cites W2054698714 @default.
• W2014610710 cites W2056289808 @default.
• W2014610710 cites W2065774340 @default.
• W2014610710 cites W2066583644 @default.
• W2014610710 cites W2073758053 @default.
• W2014610710 cites W2079596097 @default.
• W2014610710 cites W2088526037 @default.
• W2014610710 cites W2089028880 @default.
• W2014610710 cites W2092109362 @default.
• W2014610710 cites W2096781742 @default.
• W2014610710 cites W2100326545 @default.
• W2014610710 cites W2107891372 @default.
• W2014610710 cites W2121561561 @default.
• W2014610710 cites W2124806513 @default.
• W2014610710 cites W2126352920 @default.
• W2014610710 cites W2130682878 @default.
• W2014610710 cites W2139884895 @default.
• W2014610710 cites W2145133173 @default.
• W2014610710 cites W2150448842 @default.
• W2014610710 cites W2157911022 @default.
• W2014610710 cites W2161472724 @default.
• W2014610710 cites W2169554211 @default.
• W2014610710 cites W2171781387 @default.
• W2014610710 cites W4253473049 @default.
• W2014610710 cites W4255482879 @default.
• W2014610710 doi "https://doi.org/10.1016/j.radonc.2003.09.010" @default.
• W2014610710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14643949" @default.
• W2014610710 hasPublicationYear "2003" @default.
• W2014610710 type Work @default.
• W2014610710 sameAs 2014610710 @default.
• W2014610710 citedByCount "198" @default.
• W2014610710 countsByYear W20146107102012 @default.
• W2014610710 countsByYear W20146107102013 @default.
• W2014610710 countsByYear W20146107102014 @default.
• W2014610710 countsByYear W20146107102015 @default.
• W2014610710 countsByYear W20146107102016 @default.
• W2014610710 countsByYear W20146107102017 @default.
• W2014610710 countsByYear W20146107102018 @default.
• W2014610710 countsByYear W20146107102019 @default.
• W2014610710 countsByYear W20146107102020 @default.
• W2014610710 countsByYear W20146107102021 @default.
• W2014610710 countsByYear W20146107102022 @default.
• W2014610710 countsByYear W20146107102023 @default.
• W2014610710 crossrefType "journal-article" @default.
• W2014610710 hasAuthorship W2014610710A5071977658 @default.
• W2014610710 hasAuthorship W2014610710A5073129301 @default.
• W2014610710 hasAuthorship W2014610710A5080417921 @default.
• W2014610710 hasAuthorship W2014610710A5086242617 @default.
• W2014610710 hasConcept C104317684 @default.
• W2014610710 hasConcept C126322002 @default.
• W2014610710 hasConcept C135763542 @default.
• W2014610710 hasConcept C153209595 @default.
• W2014610710 hasConcept C180754005 @default.
• W2014610710 hasConcept C2776999993 @default.
• W2014610710 hasConcept C2779755913 @default.
• W2014610710 hasConcept C2780559512 @default.
• W2014610710 hasConcept C54355233 @default.
• W2014610710 hasConcept C71924100 @default.
• W2014610710 hasConcept C86803240 @default.
• W2014610710 hasConceptScore W2014610710C104317684 @default.
• W2014610710 hasConceptScore W2014610710C126322002 @default.
• W2014610710 hasConceptScore W2014610710C135763542 @default.
• W2014610710 hasConceptScore W2014610710C153209595 @default.
• W2014610710 hasConceptScore W2014610710C180754005 @default.
• W2014610710 hasConceptScore W2014610710C2776999993 @default.
• W2014610710 hasConceptScore W2014610710C2779755913 @default.
• W2014610710 hasConceptScore W2014610710C2780559512 @default.
• W2014610710 hasConceptScore W2014610710C54355233 @default.
• W2014610710 hasConceptScore W2014610710C71924100 @default.
• W2014610710 hasConceptScore W2014610710C86803240 @default.
• W2014610710 hasIssue "2" @default.

• next