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- W2014612310 abstract "The incidence of hepatocellular carcinoma is rising in many countries, including the United States. Approval of sorafenib (Nexavar) as the first targeted therapy for treatment of advanced hepatocellular carcinoma (HCC) represents a milestone in the treatment of this disease. The approval was based on two large randomized phase III trials from the Western and Eastern hemispheres that showed an overall survival benefit compared with placebo in patients with well-preserved liver function. The exact indication for sorafenib is unclear, however. The U.S. Food and Drug Administration (FDA) authorized use of sorafenib for unresectable HCC, an indication which is very broad, vague, and confusing. Less is known about the effects of sorafenib in patients with decompensated liver disease, or of sorafenib in combination with local therapy or in a transplant setting. Prospective trials are lacking in these areas. We will review current data on use of sorafenib in HCC." @default.
- W2014612310 created "2016-06-24" @default.
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- W2014612310 date "1971-01-01" @default.
- W2014612310 modified "2023-09-27" @default.
- W2014612310 title "Cytoplasmic Lipid in Ehrlich Ascites Tumor Cells Before and During Recurrent Growth" @default.
- W2014612310 doi "https://doi.org/10.1159/000224578" @default.
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