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- W2014613718 abstract "• A crystal structure of latent TGFβ explains common regulatory features. • Extracellular storage and maturation of TGFβ and related precursors. • Regulation of precursor processing by substrate-specific inhibitors. • Genetic analysis and live imaging reveal paracrine functions of proprotein convertases. • Protease–substrate interactions are regulated by spatial compartmentalization. Secreted cytokines of the TGFβ family are found in all multicellular organisms and implicated in regulating fundamental cell behaviors such as proliferation, differentiation, migration and survival. Signal transduction involves complexes of specific type I and II receptor kinases that induce the nuclear translocation of Smad transcription factors to regulate target genes. Ligands of the BMP and Nodal subgroups act at a distance to specify distinct cell fates in a concentration-dependent manner. These signaling gradients are shaped by multiple factors, including proteases of the proprotein convertase (PC) family that hydrolyze one or several peptide bonds between an N-terminal prodomain and the C-terminal domain that forms the mature ligand. This review summarizes information on the proteolytic processing of TGFβ and related precursors, and its spatiotemporal regulation by PCs during development and various diseases, including cancer. Available evidence suggests that the unmasking of receptor binding epitopes of TGFβ is only one (and in some cases a non-essential) function of precursor processing. Future studies should consider the impact of proteolytic maturation on protein localization, trafficking and turnover in cells and in the extracellular space." @default.
- W2014613718 created "2016-06-24" @default.
- W2014613718 creator A5064346931 @default.
- W2014613718 date "2014-08-01" @default.
- W2014613718 modified "2023-10-17" @default.
- W2014613718 title "Regulation of TGFβ and related signals by precursor processing" @default.
- W2014613718 cites W1480056716 @default.
- W2014613718 cites W1486556201 @default.
- W2014613718 cites W1492818016 @default.
- W2014613718 cites W1520988136 @default.
- W2014613718 cites W1546365621 @default.
- W2014613718 cites W1558226015 @default.
- W2014613718 cites W1582760249 @default.
- W2014613718 cites W163466579 @default.
- W2014613718 cites W1651423553 @default.
- W2014613718 cites W1735521937 @default.
- W2014613718 cites W1885047062 @default.
- W2014613718 cites W1964691304 @default.
- W2014613718 cites W1965152120 @default.
- W2014613718 cites W1965186550 @default.
- W2014613718 cites W1965558704 @default.
- W2014613718 cites W1967276782 @default.
- W2014613718 cites W1971127837 @default.
- W2014613718 cites W1972372687 @default.
- W2014613718 cites W1972528508 @default.
- W2014613718 cites W1972814760 @default.
- W2014613718 cites W1973689839 @default.
- W2014613718 cites W1974043792 @default.
- W2014613718 cites W1974692753 @default.
- W2014613718 cites W1975171278 @default.
- W2014613718 cites W1975913194 @default.
- W2014613718 cites W1977783490 @default.
- W2014613718 cites W1979106724 @default.
- W2014613718 cites W1980532333 @default.
- W2014613718 cites W1981102070 @default.
- W2014613718 cites W1981718544 @default.
- W2014613718 cites W1983146536 @default.
- W2014613718 cites W1983313606 @default.
- W2014613718 cites W1983759743 @default.
- W2014613718 cites W1987132484 @default.
- W2014613718 cites W1989057992 @default.
- W2014613718 cites W1989251966 @default.
- W2014613718 cites W1989874642 @default.
- W2014613718 cites W1990467912 @default.
- W2014613718 cites W1991109392 @default.
- W2014613718 cites W1993531220 @default.
- W2014613718 cites W1994876976 @default.
- W2014613718 cites W1996485730 @default.
- W2014613718 cites W1998650790 @default.
- W2014613718 cites W1998975199 @default.
- W2014613718 cites W1999375905 @default.
- W2014613718 cites W2001183029 @default.
- W2014613718 cites W2002041730 @default.
- W2014613718 cites W2006562777 @default.
- W2014613718 cites W2009065414 @default.
- W2014613718 cites W2009455581 @default.
- W2014613718 cites W2013282820 @default.
- W2014613718 cites W2013445858 @default.
- W2014613718 cites W2014449218 @default.
- W2014613718 cites W2014634831 @default.
- W2014613718 cites W2015936607 @default.
- W2014613718 cites W2017207705 @default.
- W2014613718 cites W2017464562 @default.
- W2014613718 cites W2022620053 @default.
- W2014613718 cites W2022674779 @default.
- W2014613718 cites W2023431960 @default.
- W2014613718 cites W2024791049 @default.
- W2014613718 cites W2025798304 @default.
- W2014613718 cites W2028574594 @default.
- W2014613718 cites W2030821262 @default.
- W2014613718 cites W2032435199 @default.
- W2014613718 cites W2032966714 @default.
- W2014613718 cites W2034735471 @default.
- W2014613718 cites W2036537461 @default.
- W2014613718 cites W2039118222 @default.
- W2014613718 cites W2039346229 @default.
- W2014613718 cites W2039806395 @default.
- W2014613718 cites W2040663755 @default.
- W2014613718 cites W2041573813 @default.
- W2014613718 cites W2041764051 @default.
- W2014613718 cites W2042923118 @default.
- W2014613718 cites W2044240582 @default.
- W2014613718 cites W2045017787 @default.
- W2014613718 cites W2045523681 @default.
- W2014613718 cites W2046581616 @default.
- W2014613718 cites W2049423709 @default.
- W2014613718 cites W2051816002 @default.
- W2014613718 cites W2051949327 @default.
- W2014613718 cites W2051970343 @default.
- W2014613718 cites W2054464790 @default.
- W2014613718 cites W2057714418 @default.
- W2014613718 cites W2059461233 @default.
- W2014613718 cites W2059653502 @default.
- W2014613718 cites W2059877822 @default.
- W2014613718 cites W2060515511 @default.
- W2014613718 cites W2061896987 @default.
- W2014613718 cites W2062395208 @default.
- W2014613718 cites W2062929087 @default.