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- W2014615511 abstract "DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated STP. DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel anxious at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the enhanced awareness produced by DOET was not associated with psychotomimetic or hallucinogenic actions. PSYCHEDELIC drugs embrace a large number of agents of widely different chemical classes but which produce notably similar profound subjective effects.<sup>1</sup>Nuances of subjective effects which may vary among drugs<sup>2</sup>have not been well quantified. Shulgin<sup>3.4</sup>has synthesized a large number of methoxylated amphetamines related to mescaline and amphetamine. One of these, DOM (2, 5-dimethoxy-4-methylamphetamine) (Fig 1), informally designated STP, was psychotomimetic and hallucinogenic in doses larger than 5 mg, and was about 50 to 100" @default.
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- W2014615511 date "1971-01-01" @default.
- W2014615511 modified "2023-09-23" @default.
- W2014615511 title "DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug" @default.
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- W2014615511 doi "https://doi.org/10.1001/archpsyc.1971.01750070052006" @default.
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