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- W2014618932 abstract "Angiotensin I-converting enzyme (ACE; CD143, Kininase II, EC 3.4.15.1) is known to be crucial for male fertility in animal models. We therefore studied its testicular (tACE) and somatic (sACE) isoforms in foetal and adult human testis and epididymis using monoclonal antibodies and cRNA probes. During spermatogenesis, tACE was found only in differentiating germ cells and was the only isoform within the seminiferous tubules of adult men. Although tACE mRNA was present in spermatocytes, tACE protein was initially found in post-meiotic step 3 spermatids and increased markedly during further differentiation. The enzyme was strictly confined to the adluminal membrane site of elongating spermatids and was localized at the neck and midpiece region of released and ejaculated spermatozoa. In contrast, sACE was expressed heterogeneously in Leydig cells and endothelial cells of the testicular interstitium, and homogeneously along the luminal surface of epithelial cells lining the ductuli efferents, corpus and cauda of epididymis, and vas deferens. The cell- and site-restricted pattern of sACE corresponded to that found in foetal tissues except an additional and transient expression of sACE in foetal germ cells and foetal Sertoli cells. Our study documents for the first time in humans the regulation and unique cellular distribution of ACE isoforms during the ontogenesis of the lower male genital tract." @default.
- W2014618932 created "2016-06-24" @default.
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- W2014618932 date "2003-01-31" @default.
- W2014618932 modified "2023-09-27" @default.
- W2014618932 title "Isoforms of angiotensin I-converting enzyme in the development and differentiation of human testis and epididymis" @default.
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- W2014618932 doi "https://doi.org/10.1046/j.1439-0272.2003.00535.x" @default.
- W2014618932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12558527" @default.
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