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- W2014627341 abstract "Alpha-synuclein (α-Syn), a small protein with multiple physiological and pathological functions, is one of the dominant proteins found in Lewy Bodies, a pathological hallmark of Lewy body disorders, including Parkinson's disease (PD). More recently, α-Syn has been found in body fluids, including blood and cerebrospinal fluid, and is likely produced by both peripheral tissues and the central nervous system. Exchange of α-Syn between the brain and peripheral tissues could have important pathophysiologic and therapeutic implications. However, little is known about the ability of α-Syn to cross the blood–brain barrier (BBB). Here, we found that radioactively labeled α-Syn crossed the BBB in both the brain-to-blood and the blood-to-brain directions at rates consistent with saturable mechanisms. Low-density lipoprotein receptor-related protein-1 (LRP-1), but not p-glycoprotein, may be involved in α-Syn efflux and lipopolysaccharide (LPS)-induced inflammation could increase α-Syn uptake by the brain by disrupting the BBB." @default.
- W2014627341 created "2016-06-24" @default.
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- W2014627341 date "2014-12-01" @default.
- W2014627341 modified "2023-10-18" @default.
- W2014627341 title "Alpha synuclein is transported into and out of the brain by the blood–brain barrier" @default.
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- W2014627341 doi "https://doi.org/10.1016/j.peptides.2014.09.018" @default.
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