Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014636632> ?p ?o ?g. }
- W2014636632 endingPage "785" @default.
- W2014636632 startingPage "781" @default.
- W2014636632 abstract "The induction of Per1 gene in the suprachiasmatic nucleus, the center of the circadian clock, is assumed to play significant roles in the adjustment of the internal clock. cAMP is one of the intracellular mediators which activates Per1 transcription. Here, we showed that the amount of the rat Per1 (rPer1) transcript induced by forskolin (FK) was significantly upregulated by the inhibition of phosphodiesterase type 4 (PDE4), a specific phosphodiesterase for cAMP, in rat-1 fibroblasts. Administration of rolipram, a specific inhibitor of PDE4, increased intracellular cAMP concentration, phosphorylation of cAMP response element binding protein (CREB) and enhanced rPer1 induction at their peaks. However, in the falling phase of rPer1 induction, the inhibition of PDE4 hardly affected the profile of rPer1 expression. These findings suggest the involvement of PDE4 for the regulation of rPer1 expression via cAMP metabolism at peak of the induction but little or no participation of PDE4 in the decreasing phase of the gene expression." @default.
- W2014636632 created "2016-06-24" @default.
- W2014636632 creator A5000746447 @default.
- W2014636632 creator A5005034149 @default.
- W2014636632 creator A5021359937 @default.
- W2014636632 creator A5035774490 @default.
- W2014636632 creator A5067315926 @default.
- W2014636632 date "2003-07-01" @default.
- W2014636632 modified "2023-10-14" @default.
- W2014636632 title "Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription" @default.
- W2014636632 cites W1510434099 @default.
- W2014636632 cites W1516057384 @default.
- W2014636632 cites W1534853312 @default.
- W2014636632 cites W1602960923 @default.
- W2014636632 cites W1661083499 @default.
- W2014636632 cites W1971923358 @default.
- W2014636632 cites W1973472722 @default.
- W2014636632 cites W1978248876 @default.
- W2014636632 cites W1990645149 @default.
- W2014636632 cites W1998956680 @default.
- W2014636632 cites W2009850542 @default.
- W2014636632 cites W2011636905 @default.
- W2014636632 cites W2016772352 @default.
- W2014636632 cites W2021229976 @default.
- W2014636632 cites W2028242823 @default.
- W2014636632 cites W2035809873 @default.
- W2014636632 cites W2040196614 @default.
- W2014636632 cites W2045647450 @default.
- W2014636632 cites W2057522076 @default.
- W2014636632 cites W2059668632 @default.
- W2014636632 cites W2060925737 @default.
- W2014636632 cites W2063313379 @default.
- W2014636632 cites W2085872187 @default.
- W2014636632 cites W2090816060 @default.
- W2014636632 cites W2102048968 @default.
- W2014636632 cites W2106753244 @default.
- W2014636632 cites W2113297137 @default.
- W2014636632 cites W2118646967 @default.
- W2014636632 cites W2130179391 @default.
- W2014636632 cites W2132176657 @default.
- W2014636632 cites W2137252488 @default.
- W2014636632 cites W2137947730 @default.
- W2014636632 cites W2165543096 @default.
- W2014636632 cites W2181566532 @default.
- W2014636632 doi "https://doi.org/10.1016/s0006-291x(03)01048-9" @default.
- W2014636632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12810087" @default.
- W2014636632 hasPublicationYear "2003" @default.
- W2014636632 type Work @default.
- W2014636632 sameAs 2014636632 @default.
- W2014636632 citedByCount "7" @default.
- W2014636632 crossrefType "journal-article" @default.
- W2014636632 hasAuthorship W2014636632A5000746447 @default.
- W2014636632 hasAuthorship W2014636632A5005034149 @default.
- W2014636632 hasAuthorship W2014636632A5021359937 @default.
- W2014636632 hasAuthorship W2014636632A5035774490 @default.
- W2014636632 hasAuthorship W2014636632A5067315926 @default.
- W2014636632 hasConcept C104317684 @default.
- W2014636632 hasConcept C121446783 @default.
- W2014636632 hasConcept C126322002 @default.
- W2014636632 hasConcept C134018914 @default.
- W2014636632 hasConcept C150194340 @default.
- W2014636632 hasConcept C1629964 @default.
- W2014636632 hasConcept C181199279 @default.
- W2014636632 hasConcept C184738001 @default.
- W2014636632 hasConcept C185592680 @default.
- W2014636632 hasConcept C24998067 @default.
- W2014636632 hasConcept C2776958096 @default.
- W2014636632 hasConcept C2779276759 @default.
- W2014636632 hasConcept C2779317972 @default.
- W2014636632 hasConcept C2780360009 @default.
- W2014636632 hasConcept C38606739 @default.
- W2014636632 hasConcept C55493867 @default.
- W2014636632 hasConcept C58141971 @default.
- W2014636632 hasConcept C62826618 @default.
- W2014636632 hasConcept C71924100 @default.
- W2014636632 hasConcept C86339819 @default.
- W2014636632 hasConcept C86803240 @default.
- W2014636632 hasConcept C95444343 @default.
- W2014636632 hasConceptScore W2014636632C104317684 @default.
- W2014636632 hasConceptScore W2014636632C121446783 @default.
- W2014636632 hasConceptScore W2014636632C126322002 @default.
- W2014636632 hasConceptScore W2014636632C134018914 @default.
- W2014636632 hasConceptScore W2014636632C150194340 @default.
- W2014636632 hasConceptScore W2014636632C1629964 @default.
- W2014636632 hasConceptScore W2014636632C181199279 @default.
- W2014636632 hasConceptScore W2014636632C184738001 @default.
- W2014636632 hasConceptScore W2014636632C185592680 @default.
- W2014636632 hasConceptScore W2014636632C24998067 @default.
- W2014636632 hasConceptScore W2014636632C2776958096 @default.
- W2014636632 hasConceptScore W2014636632C2779276759 @default.
- W2014636632 hasConceptScore W2014636632C2779317972 @default.
- W2014636632 hasConceptScore W2014636632C2780360009 @default.
- W2014636632 hasConceptScore W2014636632C38606739 @default.
- W2014636632 hasConceptScore W2014636632C55493867 @default.
- W2014636632 hasConceptScore W2014636632C58141971 @default.
- W2014636632 hasConceptScore W2014636632C62826618 @default.
- W2014636632 hasConceptScore W2014636632C71924100 @default.
- W2014636632 hasConceptScore W2014636632C86339819 @default.