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- W2014637776 abstract "A transforming N-ras gene has been cloned from acute myeloblastic leukemia bone marrow cells, in parallel with the N-ras gene derived from fibroblasts of the same patient. N-ras derived from fibroblasts lacked focus-forming activity in NIH/3T3 cells, indicating that gene activation in the leukemia cells must have occurred by a somatic event. Construction of chimeric molecules between the transforming and the normal N-ras genes and subsequent biological and sequence analysis of these constructs revealed that the transforming gene was altered by a point mutation changing amino acid 12 of the N-ras protein from glycine to aspartic acid." @default.
- W2014637776 created "2016-06-24" @default.
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- W2014637776 date "1985-02-01" @default.
- W2014637776 modified "2023-10-17" @default.
- W2014637776 title "Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon." @default.
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- W2014637776 doi "https://doi.org/10.1073/pnas.82.3.879" @default.
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