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- W2014639084 abstract "Abstract In order to elucidate the mechanism by which quaternary ammonium compounds are transported across the gastro-intestinal epithelium, transport of five quaternary ammonium compounds through rat intestinal brush border membrane vesicles was investigated. Transport across the intestinal brush border membrane is only observed when the organic cations possess a hydrophobic tail and their charge is somehow screened by the presence of a bulky group around the charged atom. Transport appeared to be a passive process. Uptake was stimulated by a transmembrane electrical potential difference, but not by an excess of anions like I − or taurocholate. The implications for the in vivo absorption of quaternary ammonium compounds and for their use as probes for measuring the transmembrane electrical potential difference are briefly discussed." @default.
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- W2014639084 date "1981-10-01" @default.
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- W2014639084 title "Uptake of quaternary ammonium compounds into rat intestinal brush border membrane vesicles" @default.
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- W2014639084 doi "https://doi.org/10.1016/0006-2952(81)90531-1" @default.
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