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- W2014643576 endingPage "464" @default.
- W2014643576 startingPage "449" @default.
- W2014643576 abstract "Higher-order executive tasks such as learning, working memory, and behavioral flexibility depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The prominent innervation by serotonin neurons and the dense expression of serotonergic receptors in the PFC suggest that serotonin is a major modulator of its function. The most abundant serotonin receptors in the PFC, 5-HT1A, 5-HT2A and 5-HT3A receptors, are selectively expressed in distinct populations of pyramidal neurons and inhibitory interneurons, and play a critical role in modulating cortical activity and neural oscillations (brain waves). Serotonergic signaling is altered in many psychiatric disorders such as schizophrenia and depression, where parallel changes in receptor expression and brain waves have been observed. Furthermore, many psychiatric drug treatments target serotonergic receptors in the PFC. Thus, understanding the role of serotonergic neurotransmission in PFC function is of major clinical importance. Here, we review recent findings concerning the powerful influences of serotonin on single neurons, neural networks, and cortical circuits in the PFC of the rat, where the effects of serotonin have been most thoroughly studied." @default.
- W2014643576 created "2016-06-24" @default.
- W2014643576 creator A5026772068 @default.
- W2014643576 creator A5089004514 @default.
- W2014643576 date "2011-11-11" @default.
- W2014643576 modified "2023-10-10" @default.
- W2014643576 title "Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits" @default.
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