FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014645492> ?p ?o ?g. }

• W2014645492 abstract "Previous research has demonstrated increased pain threshold during copulation, gestation, and parturition in animals. In the laboratory, mechanostimulation of the vaginocervical region in many animals, as well as humans, can increase responsiveness to noxious but not to innocuous stimuli. This increased pain inhibition to vaginocervical stimulation, which mimics natural parturition, is mediated by spinal and supraspinal neuropeptides, including the opiates. The present research was designed to ascertain the possible effects of a kappa opioid agonist on vaginocervical-stimulated analgesia in rats. Initially, the novel kappa-selective agonist, spiradoline mesylate (U62,066E; 0, 0.1, 1.0, 10.0 mg/kg, i.p.), was injected intraperitoneally and general behavioral arousal in an open field apparatus was recorded. Results from this experiment indicate that stimulation with the kappa-selective drug caused significant decreases in behavioral activity at the high dose as compared to saline and the medium and low doses. Next, the effects of U62,066E (0, 0.1, 1.0, 10.0 mg/kg, i.p.) on the analgesia associated with vaginocervical stimulation were determined in a tail flick apparatus. The kappa drug significantly increased antinociceptive thresholds prior to and during vaginocervical stimulation at the 0.1 and 1.0 mg/kg doses. By contrast, the high dose (10.0 mg/kg) of U62,066E decreased vaginocervical stimulation-produced analgesia. Results are discussed in terms of the potential of nonaddictive kappa-selective opioid compounds being utilized in reproductive pain." @default.
• W2014645492 created "2016-06-24" @default.
• W2014645492 creator A5030980242 @default.
• W2014645492 creator A5044204904 @default.
• W2014645492 creator A5069087687 @default.
• W2014645492 date "2001-01-01" @default.
• W2014645492 modified "2023-09-26" @default.
• W2014645492 title "Effects of a kappa agonist, spiradoline mesylate (U62,066E), on activation and vaginocervical-stimulation produced analgesia in rats" @default.
• W2014645492 cites W1918820105 @default.
• W2014645492 cites W1934959161 @default.
• W2014645492 cites W1965330319 @default.
• W2014645492 cites W1966182087 @default.
• W2014645492 cites W1968688885 @default.
• W2014645492 cites W1969831870 @default.
• W2014645492 cites W1982531932 @default.
• W2014645492 cites W1989249020 @default.
• W2014645492 cites W1991556967 @default.
• W2014645492 cites W1995256958 @default.
• W2014645492 cites W1995492072 @default.
• W2014645492 cites W1995749463 @default.
• W2014645492 cites W1997802449 @default.
• W2014645492 cites W2007286206 @default.
• W2014645492 cites W2007532692 @default.
• W2014645492 cites W2015532230 @default.
• W2014645492 cites W2022590753 @default.
• W2014645492 cites W2023131011 @default.
• W2014645492 cites W2023702492 @default.
• W2014645492 cites W2023830317 @default.
• W2014645492 cites W2027694520 @default.
• W2014645492 cites W2039170232 @default.
• W2014645492 cites W2043130405 @default.
• W2014645492 cites W2043466388 @default.
• W2014645492 cites W2048266228 @default.
• W2014645492 cites W2052485536 @default.
• W2014645492 cites W2060334160 @default.
• W2014645492 cites W2062866484 @default.
• W2014645492 cites W2068380366 @default.
• W2014645492 cites W2073214521 @default.
• W2014645492 cites W2079852966 @default.
• W2014645492 cites W2080714523 @default.
• W2014645492 cites W2083600423 @default.
• W2014645492 cites W2084230118 @default.
• W2014645492 cites W2084757489 @default.
• W2014645492 cites W2087079459 @default.
• W2014645492 cites W2087731725 @default.
• W2014645492 cites W2088535017 @default.
• W2014645492 cites W2088783162 @default.
• W2014645492 cites W2146166752 @default.
• W2014645492 cites W2412830492 @default.
• W2014645492 doi "https://doi.org/10.1016/s0361-9230(00)00453-6" @default.
• W2014645492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275411" @default.
• W2014645492 hasPublicationYear "2001" @default.
• W2014645492 type Work @default.
• W2014645492 sameAs 2014645492 @default.
• W2014645492 citedByCount "5" @default.
• W2014645492 crossrefType "journal-article" @default.
• W2014645492 hasAuthorship W2014645492A5030980242 @default.
• W2014645492 hasAuthorship W2014645492A5044204904 @default.
• W2014645492 hasAuthorship W2014645492A5069087687 @default.
• W2014645492 hasConcept C104211972 @default.
• W2014645492 hasConcept C126322002 @default.
• W2014645492 hasConcept C134018914 @default.
• W2014645492 hasConcept C15490471 @default.
• W2014645492 hasConcept C170493617 @default.
• W2014645492 hasConcept C184389661 @default.
• W2014645492 hasConcept C185592680 @default.
• W2014645492 hasConcept C24998067 @default.
• W2014645492 hasConcept C2777389121 @default.
• W2014645492 hasConcept C2777397205 @default.
• W2014645492 hasConcept C2777972943 @default.
• W2014645492 hasConcept C2778938600 @default.
• W2014645492 hasConcept C2780820201 @default.
• W2014645492 hasConcept C2781063702 @default.
• W2014645492 hasConcept C42219234 @default.
• W2014645492 hasConcept C71924100 @default.
• W2014645492 hasConcept C98274493 @default.
• W2014645492 hasConceptScore W2014645492C104211972 @default.
• W2014645492 hasConceptScore W2014645492C126322002 @default.
• W2014645492 hasConceptScore W2014645492C134018914 @default.
• W2014645492 hasConceptScore W2014645492C15490471 @default.
• W2014645492 hasConceptScore W2014645492C170493617 @default.
• W2014645492 hasConceptScore W2014645492C184389661 @default.
• W2014645492 hasConceptScore W2014645492C185592680 @default.
• W2014645492 hasConceptScore W2014645492C24998067 @default.
• W2014645492 hasConceptScore W2014645492C2777389121 @default.
• W2014645492 hasConceptScore W2014645492C2777397205 @default.
• W2014645492 hasConceptScore W2014645492C2777972943 @default.
• W2014645492 hasConceptScore W2014645492C2778938600 @default.
• W2014645492 hasConceptScore W2014645492C2780820201 @default.
• W2014645492 hasConceptScore W2014645492C2781063702 @default.
• W2014645492 hasConceptScore W2014645492C42219234 @default.
• W2014645492 hasConceptScore W2014645492C71924100 @default.
• W2014645492 hasConceptScore W2014645492C98274493 @default.
• W2014645492 hasLocation W20146454921 @default.
• W2014645492 hasLocation W20146454922 @default.
• W2014645492 hasOpenAccess W2014645492 @default.
• W2014645492 hasPrimaryLocation W20146454921 @default.
• W2014645492 hasRelatedWork W1910691439 @default.
• W2014645492 hasRelatedWork W1980573795 @default.
• W2014645492 hasRelatedWork W1985187234 @default.

• next