FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014646090> ?p ?o ?g. }

• W2014646090 endingPage "250" @default.
• W2014646090 startingPage "241" @default.
• W2014646090 abstract "Mutations in apolipoprotein A-I (apoA-I) may affect plasma high-density lipoprotein (HDL) cholesterol levels and the risk for cardiovascular disease but little is known about the presence and effects of circulating apoA-I variants. This study investigates whether the apoA-I mutations, apoA-I(L202P) and apoA-I(K131del) , are present on plasma HDL particles derived from heterozygote carriers and whether this is associated to changes in HDL protein composition.Plasma HDL of heterozygotes for either apoA-I(L202P) or apoA-I(K131del) and family controls was isolated using ultracentrifugation. HDL proteins were separated by 2DE and analyzed by MS.ApoA-I peptides containing apoA-I(L202P) or apoA-I(K131del) were identified in HDL from heterozygotes. The apoA-I(L202P) mutant peptide was less abundant than wild-type peptide while the apoA-I(K131del) mutant peptide was more abundant than wild-type peptide in the heterozygotes. Two-dimensional gel electrophoresis analyses indicated that, compared to controls, HDL in apoA-I(L202P) carriers contained less apoE and more zinc-α-2-glycoprotein while HDL from the apoA-I(K131del) heterozygotes contained more alpha-1-antitrypsin and transthyretin.Both apoA-I(L202P) and apoA-I(K131del) were identified in HDL. In heterozygotes, these mutations have markedly differential effects on the concentration of wild-type apoA-I in the circulation, as well as the HDL proteome, both of which might affect the clinical phenotype encountered in the heterozygous carriers." @default.
• W2014646090 created "2016-06-24" @default.
• W2014646090 creator A5013598309 @default.
• W2014646090 creator A5016178530 @default.
• W2014646090 creator A5021562147 @default.
• W2014646090 creator A5045994624 @default.
• W2014646090 creator A5053113530 @default.
• W2014646090 creator A5058571312 @default.
• W2014646090 creator A5060529589 @default.
• W2014646090 creator A5066393006 @default.
• W2014646090 creator A5073506012 @default.
• W2014646090 creator A5084263623 @default.
• W2014646090 date "2014-02-12" @default.
• W2014646090 modified "2023-09-23" @default.
• W2014646090 title "ApoA-I mutations, L202P and K131del, in HDL from heterozygotes with low HDL-C" @default.
• W2014646090 cites W1580211147 @default.
• W2014646090 cites W1863056418 @default.
• W2014646090 cites W1966091911 @default.
• W2014646090 cites W1972479546 @default.
• W2014646090 cites W1977373454 @default.
• W2014646090 cites W1978216187 @default.
• W2014646090 cites W1979355058 @default.
• W2014646090 cites W1994016991 @default.
• W2014646090 cites W2000703690 @default.
• W2014646090 cites W2005055200 @default.
• W2014646090 cites W2008001498 @default.
• W2014646090 cites W2010588191 @default.
• W2014646090 cites W2012650964 @default.
• W2014646090 cites W2019108597 @default.
• W2014646090 cites W2029841039 @default.
• W2014646090 cites W2044487035 @default.
• W2014646090 cites W2054040066 @default.
• W2014646090 cites W2060003997 @default.
• W2014646090 cites W2063174765 @default.
• W2014646090 cites W2066776235 @default.
• W2014646090 cites W2070162893 @default.
• W2014646090 cites W2071043133 @default.
• W2014646090 cites W2076962828 @default.
• W2014646090 cites W2077109398 @default.
• W2014646090 cites W2083315579 @default.
• W2014646090 cites W2088797695 @default.
• W2014646090 cites W2092688668 @default.
• W2014646090 cites W2100342973 @default.
• W2014646090 cites W2106395054 @default.
• W2014646090 cites W2110282870 @default.
• W2014646090 cites W2117622925 @default.
• W2014646090 cites W2123715983 @default.
• W2014646090 cites W2125065061 @default.
• W2014646090 cites W2127427274 @default.
• W2014646090 cites W2145195851 @default.
• W2014646090 cites W2145647912 @default.
• W2014646090 cites W2145813488 @default.
• W2014646090 cites W2163483547 @default.
• W2014646090 cites W2285831485 @default.
• W2014646090 cites W2314049540 @default.
• W2014646090 cites W4296926797 @default.
• W2014646090 doi "https://doi.org/10.1002/prca.201300014" @default.
• W2014646090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24273187" @default.
• W2014646090 hasPublicationYear "2014" @default.
• W2014646090 type Work @default.
• W2014646090 sameAs 2014646090 @default.
• W2014646090 citedByCount "5" @default.
• W2014646090 countsByYear W20146460902019 @default.
• W2014646090 countsByYear W20146460902020 @default.
• W2014646090 countsByYear W20146460902021 @default.
• W2014646090 countsByYear W20146460902022 @default.
• W2014646090 crossrefType "journal-article" @default.
• W2014646090 hasAuthorship W2014646090A5013598309 @default.
• W2014646090 hasAuthorship W2014646090A5016178530 @default.
• W2014646090 hasAuthorship W2014646090A5021562147 @default.
• W2014646090 hasAuthorship W2014646090A5045994624 @default.
• W2014646090 hasAuthorship W2014646090A5053113530 @default.
• W2014646090 hasAuthorship W2014646090A5058571312 @default.
• W2014646090 hasAuthorship W2014646090A5060529589 @default.
• W2014646090 hasAuthorship W2014646090A5066393006 @default.
• W2014646090 hasAuthorship W2014646090A5073506012 @default.
• W2014646090 hasAuthorship W2014646090A5084263623 @default.
• W2014646090 hasBestOaLocation W20146460902 @default.
• W2014646090 hasConcept C104317684 @default.
• W2014646090 hasConcept C12125453 @default.
• W2014646090 hasConcept C126322002 @default.
• W2014646090 hasConcept C134018914 @default.
• W2014646090 hasConcept C143065580 @default.
• W2014646090 hasConcept C153471976 @default.
• W2014646090 hasConcept C180754005 @default.
• W2014646090 hasConcept C2778163477 @default.
• W2014646090 hasConcept C2779134260 @default.
• W2014646090 hasConcept C2780072125 @default.
• W2014646090 hasConcept C2780541478 @default.
• W2014646090 hasConcept C501734568 @default.
• W2014646090 hasConcept C55493867 @default.
• W2014646090 hasConcept C57089818 @default.
• W2014646090 hasConcept C62746215 @default.
• W2014646090 hasConcept C71924100 @default.
• W2014646090 hasConcept C86803240 @default.
• W2014646090 hasConceptScore W2014646090C104317684 @default.
• W2014646090 hasConceptScore W2014646090C12125453 @default.
• W2014646090 hasConceptScore W2014646090C126322002 @default.

• next