FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014646994> ?p ?o ?g. }

• W2014646994 endingPage "420" @default.
• W2014646994 startingPage "414" @default.
• W2014646994 abstract "The aims of this work were to test whether human intervertebral disc-derived nucleus pulposus cells (hNP-cells) are attracted by human serum and to analyze if matrix generation from hNP-cells is promoted under the influence of transforming growth factor-β3 (TGF-β3) or hyaluronan (HA) in vitro. Using the multi-well chemotaxis assay to determine cell migration under the influence of different concentrations of human serum, it was demonstrated that dedifferentiated hNP-cells are able to migrate towards a serum fraction gradient in a concentration-dependent manner. Re-differentiation capacity of hNP-cells in 3D micro-masses under the influence of TGF-β3 or hyaluronan was also tested. Gene expression analysis of types I, II, III and IX collagen, as well as aggrecan, COMP and LINK of hNP-cells in 3D-micro-mass cell-culture revealed a strong increase of these markers in TGF-β3 treated cells. Furthermore, histochemical and immuno-histochemical staining after 28d showed proteoglycan and type II collagen-rich matrix for both, the TGF-β3 and the hyaluronan treated cells. These findings show that TGF-β3 or hyaluronan are able to induce the differentiation and that human serum stimulates the migration of hNP-cells in vitro. Therefore, hyaluronan and serum are suited for cell-free biomaterials as cell migration and differentiation inducing factors intended for biological treatment strategies of the intervertebral disc." @default.
• W2014646994 created "2016-06-24" @default.
• W2014646994 creator A5011042518 @default.
• W2014646994 creator A5015033538 @default.
• W2014646994 creator A5015475422 @default.
• W2014646994 creator A5019415649 @default.
• W2014646994 creator A5021853236 @default.
• W2014646994 creator A5036014543 @default.
• W2014646994 creator A5038061458 @default.
• W2014646994 creator A5043510000 @default.
• W2014646994 creator A5052421968 @default.
• W2014646994 creator A5077732613 @default.
• W2014646994 date "2009-12-01" @default.
• W2014646994 modified "2023-10-01" @default.
• W2014646994 title "Human intervertebral disc-derived cells are recruited by human serum and form nucleus pulposus-like tissue upon stimulation with TGF-β3 or hyaluronan in vitro" @default.
• W2014646994 cites W1544751778 @default.
• W2014646994 cites W1968912769 @default.
• W2014646994 cites W1975578801 @default.
• W2014646994 cites W1977804772 @default.
• W2014646994 cites W1982643221 @default.
• W2014646994 cites W1983241347 @default.
• W2014646994 cites W1983915845 @default.
• W2014646994 cites W1987228671 @default.
• W2014646994 cites W1989629464 @default.
• W2014646994 cites W1990668863 @default.
• W2014646994 cites W2000783985 @default.
• W2014646994 cites W2009390538 @default.
• W2014646994 cites W2010934529 @default.
• W2014646994 cites W2012553154 @default.
• W2014646994 cites W2012956952 @default.
• W2014646994 cites W2020498513 @default.
• W2014646994 cites W2022804076 @default.
• W2014646994 cites W2024231718 @default.
• W2014646994 cites W2030604088 @default.
• W2014646994 cites W2035534796 @default.
• W2014646994 cites W2038420290 @default.
• W2014646994 cites W2046908945 @default.
• W2014646994 cites W2049539822 @default.
• W2014646994 cites W2053307155 @default.
• W2014646994 cites W2059808378 @default.
• W2014646994 cites W2062121465 @default.
• W2014646994 cites W2079010145 @default.
• W2014646994 cites W2079861689 @default.
• W2014646994 cites W2084508550 @default.
• W2014646994 cites W2091018106 @default.
• W2014646994 cites W2108823909 @default.
• W2014646994 cites W2118727609 @default.
• W2014646994 cites W2155704507 @default.
• W2014646994 cites W2166016039 @default.
• W2014646994 cites W4361868416 @default.
• W2014646994 doi "https://doi.org/10.1016/j.tice.2009.05.006" @default.
• W2014646994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19631359" @default.
• W2014646994 hasPublicationYear "2009" @default.
• W2014646994 type Work @default.
• W2014646994 sameAs 2014646994 @default.
• W2014646994 citedByCount "33" @default.
• W2014646994 countsByYear W20146469942012 @default.
• W2014646994 countsByYear W20146469942013 @default.
• W2014646994 countsByYear W20146469942014 @default.
• W2014646994 countsByYear W20146469942015 @default.
• W2014646994 countsByYear W20146469942018 @default.
• W2014646994 countsByYear W20146469942019 @default.
• W2014646994 countsByYear W20146469942020 @default.
• W2014646994 countsByYear W20146469942022 @default.
• W2014646994 countsByYear W20146469942023 @default.
• W2014646994 crossrefType "journal-article" @default.
• W2014646994 hasAuthorship W2014646994A5011042518 @default.
• W2014646994 hasAuthorship W2014646994A5015033538 @default.
• W2014646994 hasAuthorship W2014646994A5015475422 @default.
• W2014646994 hasAuthorship W2014646994A5019415649 @default.
• W2014646994 hasAuthorship W2014646994A5021853236 @default.
• W2014646994 hasAuthorship W2014646994A5036014543 @default.
• W2014646994 hasAuthorship W2014646994A5038061458 @default.
• W2014646994 hasAuthorship W2014646994A5043510000 @default.
• W2014646994 hasAuthorship W2014646994A5052421968 @default.
• W2014646994 hasAuthorship W2014646994A5077732613 @default.
• W2014646994 hasConcept C105702510 @default.
• W2014646994 hasConcept C106487976 @default.
• W2014646994 hasConcept C118131993 @default.
• W2014646994 hasConcept C142724271 @default.
• W2014646994 hasConcept C1491633281 @default.
• W2014646994 hasConcept C153074725 @default.
• W2014646994 hasConcept C153911025 @default.
• W2014646994 hasConcept C185592680 @default.
• W2014646994 hasConcept C189165786 @default.
• W2014646994 hasConcept C197534660 @default.
• W2014646994 hasConcept C202751555 @default.
• W2014646994 hasConcept C203014093 @default.
• W2014646994 hasConcept C204787440 @default.
• W2014646994 hasConcept C2776164576 @default.
• W2014646994 hasConcept C2777529286 @default.
• W2014646994 hasConcept C2777755357 @default.
• W2014646994 hasConcept C2779335624 @default.
• W2014646994 hasConcept C3020332539 @default.
• W2014646994 hasConcept C43617362 @default.
• W2014646994 hasConcept C55493867 @default.
• W2014646994 hasConcept C71924100 @default.
• W2014646994 hasConcept C86803240 @default.

• next