Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014649265> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2014649265 abstract "Di Giovanni et al ., who previously identified a group of temporally correlated genes that appear after spinal cord injury, including some known to be involved in neurite outgrowth and axon regeneration, undertook a search for a transcription factor that might coordinately regulate their expression. In silico promoter analysis revealed that two of these genes, the gene encoding the actin-binding Coronin 1b and the small guanosine triphosphatase Rab13 (both implicated in neurite outgrowth), had multiple binding sites for the transcription factor p53. Chromatin immunoprecipitation (ChIP) analysis confirmed that p53 bound to the Coronin 1b and Rab13 promoters, and p53 expression enhanced expression of their mRNA and protein in various cell lines. In cultured rat cortical neurons exposed to neuronal medium or PC12 cells exposed to nerve growth factor, nuclear p53 abundance increased together with expression of Coronin 1b and Rab13 during neurite outgrowth, whereas a p53 dominant negative inhibited Coronin 1b and Rab13 expression and neurite outgrowth. In NT2/D1 human teratocarcinoma cells, which develop neurites and synapses in response to treatment with retinoic acid (RA), RA stimulated acetylation of p53 at lysine 320. ChIP analysis and experiments involving p53 acetylation mutants indicated that p53 acetylated at lysine 320 binds to the Coronin 1b and Rab13 promoters to stimulate Coronin 1b and Rab13 expression and neurite outgrowth. Mice lacking p53 showed decreased nerve regeneration after axotomy compared with wild-type mice and, unlike regenerating neurons in wild-type mice, those in p53-null mice did not show enhanced expression of Coronin 1b and Rab13. Thus, the authors conclude that the well-known tumor suppressor p53, already implicated in neuronal apoptosis, likely plays a role in stimulating neurite outgrowth and neuronal regeneration. S. Di Giovanni, C. D. Knights, M. Rao, A. Yakovlev, J. Beers, J. Catania, M. L. Avantaggiati, A. I. Faden, The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J. 25 , 4084-4096 (2006). [PubMed]" @default.
- W2014649265 created "2016-06-24" @default.
- W2014649265 creator A5077591824 @default.
- W2014649265 date "2006-09-13" @default.
- W2014649265 modified "2023-09-23" @default.
- W2014649265 title "Promoting Regeneration Rather Than Death?" @default.
- W2014649265 doi "https://doi.org/10.1126/stke.3532006tw319" @default.
- W2014649265 hasPublicationYear "2006" @default.
- W2014649265 type Work @default.
- W2014649265 sameAs 2014649265 @default.
- W2014649265 citedByCount "0" @default.
- W2014649265 crossrefType "journal-article" @default.
- W2014649265 hasAuthorship W2014649265A5077591824 @default.
- W2014649265 hasConcept C101762097 @default.
- W2014649265 hasConcept C104317684 @default.
- W2014649265 hasConcept C113246987 @default.
- W2014649265 hasConcept C134320426 @default.
- W2014649265 hasConcept C150194340 @default.
- W2014649265 hasConcept C153911025 @default.
- W2014649265 hasConcept C160539049 @default.
- W2014649265 hasConcept C170493617 @default.
- W2014649265 hasConcept C171056886 @default.
- W2014649265 hasConcept C202751555 @default.
- W2014649265 hasConcept C2779683492 @default.
- W2014649265 hasConcept C54355233 @default.
- W2014649265 hasConcept C86339819 @default.
- W2014649265 hasConcept C86803240 @default.
- W2014649265 hasConcept C92020748 @default.
- W2014649265 hasConcept C95444343 @default.
- W2014649265 hasConceptScore W2014649265C101762097 @default.
- W2014649265 hasConceptScore W2014649265C104317684 @default.
- W2014649265 hasConceptScore W2014649265C113246987 @default.
- W2014649265 hasConceptScore W2014649265C134320426 @default.
- W2014649265 hasConceptScore W2014649265C150194340 @default.
- W2014649265 hasConceptScore W2014649265C153911025 @default.
- W2014649265 hasConceptScore W2014649265C160539049 @default.
- W2014649265 hasConceptScore W2014649265C170493617 @default.
- W2014649265 hasConceptScore W2014649265C171056886 @default.
- W2014649265 hasConceptScore W2014649265C202751555 @default.
- W2014649265 hasConceptScore W2014649265C2779683492 @default.
- W2014649265 hasConceptScore W2014649265C54355233 @default.
- W2014649265 hasConceptScore W2014649265C86339819 @default.
- W2014649265 hasConceptScore W2014649265C86803240 @default.
- W2014649265 hasConceptScore W2014649265C92020748 @default.
- W2014649265 hasConceptScore W2014649265C95444343 @default.
- W2014649265 hasLocation W20146492651 @default.
- W2014649265 hasOpenAccess W2014649265 @default.
- W2014649265 hasPrimaryLocation W20146492651 @default.
- W2014649265 hasRelatedWork W1524328005 @default.
- W2014649265 hasRelatedWork W1537459995 @default.
- W2014649265 hasRelatedWork W2030649090 @default.
- W2014649265 hasRelatedWork W2474555466 @default.
- W2014649265 hasRelatedWork W2525221589 @default.
- W2014649265 hasRelatedWork W2525929137 @default.
- W2014649265 hasRelatedWork W2604614450 @default.
- W2014649265 hasRelatedWork W2734507800 @default.
- W2014649265 hasRelatedWork W2944223323 @default.
- W2014649265 hasRelatedWork W4238422306 @default.
- W2014649265 isParatext "false" @default.
- W2014649265 isRetracted "false" @default.
- W2014649265 magId "2014649265" @default.
- W2014649265 workType "article" @default.