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- W2014649941 abstract "Antibodies to a ribosomal antigen were detected in the sera of 11 of the 85 patients with SLE by direct precipitation and in 35 of the 85 patients by more sensitive assay procedures. They were not found in the sera of normal individuals or in a limited group of patients with various other diseases. The antigen was shown to be an integral part of ribosomes, and was not detected in soluble material free of ribosomes. The antibodies in all of the sera were similar and were unusual in that they failed to distinguish the ribosomes from four mammalian species. Formation of a single precipitin line without spur formation indicated that similar antigenic determinants were detected in the different ribosomes. These determinants appeared to be lacking in bacterial ribosomes. The antigen's sensitivity to trypsin and ribonuclease suggested that both RNA and protein were involved." @default.
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- W2014649941 date "1967-11-01" @default.
- W2014649941 modified "2023-10-11" @default.
- W2014649941 title "Precipitating antibodies to ribosomes in the serum of patients with systemic lupus erythematosus" @default.
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- W2014649941 doi "https://doi.org/10.1016/0019-2791(67)90103-6" @default.
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